Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor

Li, Kai; Chatterjee, Avradip; Qian, Chen; Lagree, Katherine; Wang, Yang; Becker, Courtney A.; Freeman, Michael R.; Murali, Ramachandran; Yang, Wei; Underhill, David M.

doi:10.1038/s41586-024-07499-6

Nature

2024

DOI: 10.1038/s41586-024-07499-6

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Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor

Kai Li,

Avradip Chatterjee,

Chen Qian

et al.

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Cited by 7 publications

References 67 publications

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Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations

Breckels,

Hutchings,

Ingole

et al. 2024

Cell Chemical Biology

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Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations

Breckels,

Hutchings,

Ingole

et al. 2024

Cell Chemical Biology

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Intestinal fungal-host interactions in promoting and maintaining health

Hill,

Round

2024

Cell Host & Microbe

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Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction

Wang,

Wang

et al. 2024

Anal. Chem.

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Cell-cell interactions determine the activation state and function of cells. When host cells are exposed to stressors such as microorganisms, immune defense machinery is activated to release H 2 O 2 , providing direct evidence of the relevant cellular physiological processes. Inspired by the fact that peroxidase can catalyze proximity labeling in the presence of exogenous H 2 O 2 , a stressor-actuated proximity labeling (SAPL) strategy is developed to report the process information on cell−cell interactions by recording stress levels. The stressors are covalently modified with horseradish peroxidase (HRP) and the H 2 O 2 released by the host cells in response to the stressors triggers HRP-based proximity labeling. Using a fungal mimic or live fungi as stressors, the stress levels of different host cells are compared by in situ imaging of the labeling signals.The ability to accumulate stress signals allows SAPL to more sensitively differentiate between interactions involving different macrophage phenotypes. SAPL is also a powerful tool for real-time, in situ monitoring of the effects of surface modifications on cellular interactions. Thus, the SAPL strategy represents a new perspective in the monitoring of cell−cell interactions using endogenous effector molecules.

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Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor

Cited by 7 publications

References 67 publications

Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations

Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations

Intestinal fungal-host interactions in promoting and maintaining health

Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction

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