2020
DOI: 10.1186/s12967-020-02552-0
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Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma

Abstract: Background Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes, unfavorable prognosis, and treatment resistance. Recent studies have highlighted that long non-coding RNAs (lncRNAs) are key mediators in cancer mesenchymal transition. However, the relationship between lncRNAs and PMT in glioma has not been systematically investigated. … Show more

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Cited by 30 publications
(18 citation statements)
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“…Moreover, according to the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm 55 , T cells in IC Mid and IC High clusters tended to be dysfunctional ( Figure S13 ). Consistently, IC Mid and IC High clusters showed increased immunosuppressive scores calculated by the method described previously ( Figure S14 A lower panel, Table S6 ) 56 . Together, these findings suggest that clusters with inflammasome signaling activation exhibited an immunosuppressive phenotype.…”
Section: Resultssupporting
confidence: 83%
“…Moreover, according to the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm 55 , T cells in IC Mid and IC High clusters tended to be dysfunctional ( Figure S13 ). Consistently, IC Mid and IC High clusters showed increased immunosuppressive scores calculated by the method described previously ( Figure S14 A lower panel, Table S6 ) 56 . Together, these findings suggest that clusters with inflammasome signaling activation exhibited an immunosuppressive phenotype.…”
Section: Resultssupporting
confidence: 83%
“…The mesenchymal subtype is dominated in the relapses of GBM, and it has been revealed that cells of this subtype may have a higher therapy resistance (9). The overexpression of mesenchymal subtype (MES) related genes is adequate to induce invasive behavior in tumors and result in poor prognosis in patients (10).…”
Section: Introductionmentioning
confidence: 99%
“…Colorectal neoplasia differentially expressed ( CRNDE ) was discovered first as overexpressed gene in colorectal adenomas and adenocarcinomas [ 47 ]. Since that it was associated with different human malignancies [ 48 ] including glioblastoma [ 49 , 50 ]. CRNDE is located on chromosome 16 [ 41 ] and is transcribed to form multiple RNA transcripts, some of which function as noncoding regulatory RNAs.…”
Section: Discussionmentioning
confidence: 99%