Progenitor cell diversity in the developing mouse neocortex

Ruan, Xiangbin; Kang, Bowei; Cai, Qingsong; Lin, Wenhe; Wang, Jingshu; Zhang, Xiaochang

doi:10.1073/pnas.2018866118

Cited by 48 publications

(38 citation statements)

References 51 publications

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“…We can capture that APs sending most the signals in cluster 1 which coordinates with mainly APs had interactions with other cell types in early stage through incoming or outgoing signals. L-R genes of cluster 1 significantly enriched in regulating pluripotency of stem cell functions, which coordinates with the results that APs in E12.5 encode cues for neurogenesis [25] . IPs send most of the signals in cluster 4, which is consistent with mainly IPs interacted with other cell types in the middle stage through incoming or outgoing signals.…”

Section: Discussionsupporting

confidence: 83%

dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain

Song

Wang²,

Wu³

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Discussionsupporting

confidence: 83%

dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain

Song

Wang²,

Wu³

et al. 2022

Computational and Structural Biotechnology Journal

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“…In mice, the gestational age window, E11.5-E14.5, indicates a progenitor-driven phase, and at birth (P0), all six neocortical layers have grown. Neuronal stem cells in the VZ, intermediate progenitors in the subcellular ventricular zone (SVZ), and radial glia in the cerebral cortex divide symmetrically or asymmetrically around E11.5 to form more intermediate progenitors or pyramidal neurons [62,63]. Terminally developed neurons move radially from E12.5 to E14.5 to produce cortical layers and lamina from the inside out.…”

Section: Is the Gestational Timing Of The Infection Key To The Development Of Asd-like Brain Disorders?mentioning

confidence: 99%

Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development

Jash

Sharma

2022

Pathogens

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Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause diseases is a topic of critical discussion among scientists and pharmaceutical centers for effective drug development that diagnose, treat, and prevent infection-associated disorders. Pathogens impact health either directly by invading the host or by eliciting an acute inflammatory immune response. This paradigm of inflammatory immune responses is even more consequential in people who may be immunocompromised. In this regard, pregnancy offers an altered immunity scenario, which may allow the onset of severe diseases. Viruses, such as Influenza, HIV, and now SARS-CoV-2, associated with the COVID-19 pandemic, raise new concerns for maternal and fetal/neonatal health. Intrauterine bacterial and parasitic infections are also known to impact pregnancy outcomes and neonatal health. More importantly, viral and bacterial infections during pregnancy have been identified as a common contributor to fetal brain development defects. Infection-mediated inflammatory uterine immune milieu is thought to be the main trigger for causing poor fetal brain development, resulting in long-term cognitive impairments. The concept of in utero programming of childhood and adult disorders has revolutionized the field of neurodevelopment and its associated complications. Recent findings in mice and humans clearly support the idea that uterine immunity during pregnancy controls the health trajectory of the child and considerably influences the cognitive function and mental health. In this review, we focus on the in utero programming of autism spectrum disorders (ASD) and assess the effects of pathogens on the onset of ASD-like symptoms.

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“…How this is controlled in the ENS has not yet been investigated. In the central nervous system, Hes5 expression has been identified in radial glial cells ( Ruan et al, 2021 ) and is also important for maintaining oligodendrocyte precursors as proliferating cells, preventing their differentiation ( Sock and Wegner, 2021 ). Interestingly, Hes5 achieves this by preventing the interaction of Sox10 with its downstream myelinating genes.…”

Section: Factors That Control Glial Differentiationmentioning

confidence: 99%

Development, Diversity, and Neurogenic Capacity of Enteric Glia

Boesmans

Nash

Tasnády

et al. 2022

Front. Cell Dev. Biol.

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Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the “support” cells of the enteric nervous system, studies over the past 20 years have unveiled a vast array of functions carried out by enteric glia. They mediate enteric nervous system signalling and play a vital role in the local regulation of gut functions. Enteric glial cells interact with other gastrointestinal cell types such as those of the epithelium and immune system to preserve homeostasis, and are perceptive to luminal content. Their functional versatility and phenotypic heterogeneity are mirrored by an extensive level of plasticity, illustrated by their reactivity in conditions associated with enteric nervous system dysfunction and disease. As one of the hallmarks of their plasticity and extending their operative relationship with enteric neurons, enteric glia also display neurogenic potential. In this review, we focus on the development of enteric glial cells, and the mechanisms behind their heterogeneity in the adult gut. In addition, we discuss what is currently known about the role of enteric glia as neural precursors in the enteric nervous system.

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Progenitor cell diversity in the developing mouse neocortex

Cited by 48 publications

References 51 publications

dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain

dsCellNet: A new computational tool to infer cell–cell communication networks in the developing and aging brain

Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development

Development, Diversity, and Neurogenic Capacity of Enteric Glia

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