2023
DOI: 10.21203/rs.3.rs-3029459/v1
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Progesterone-induced Progesterone Receptor Membrane Component 1 Rise-to- Decline Changes are Essential for Decidualization

Abstract: Background Decidualization of endometrial cells is the prerequisite for embryo implantation and subsequent placenta formation and is induced by rising progesterone levels following ovulation. One of the hormone receptors contributing to endometrial homeostasis is Progesterone Receptor Membrane Component 1 (PGRMC1), a non-classical membrane-bound progesterone receptor with yet unclear function. In this study, we aimed to investigate how PGRMC1 contributes to human decidualization. Methods To gain insight into… Show more

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