Progesterone Receptor Modulator for Emergency Contraception

Abstract

I.

Use of IUDs for emergency contraception: current perspectives

“…11,12 Moreover, as the interval since unprotected intercourse increases, the efficacy of LNG declines. 13 UPA, however, continues to be effective for up to 120 hours, with no decline in efficacy over this time period, 14 and is significantly more effective than LNG when 72 to 120 hours have elapsed since unprotected intercourse. Figure 1 illustrates the " window of opportunity" for the action of the three emergency contraception options.…”

Gynaecological uses of a new class of steroids: the selective progesterone receptor modulators

“…Nausea, as a side effect, has not been reported in other trials with VA 2914 at higher doses. Moreover, VA 2914 was also effective in preventing pregnancy when administered after ovulation [36]. In both groups, women experienced considerable variation in menstrual cycle length when compared with their reported individual normal cycle length.…”

“…Several approaches to EC have been described, including high doses of estrogens, danazol, intrauterine devices, oral contraceptive with estrogen and progestin [36], a progestin alone (levonorgestrel) and SPRMs (mifepristone and VA 2914). The Yuzpe regimen involved the combined use of ethinyl estradiol 100 mg and 0.5 mg of levonorgestrel, repeated once 12 hours apart, with the first dose given within 72 hours of unprotected intercourse.…”

Emergency Contraception

“…UPA korunmasız cinsel ilişkiden 120 saat sonrasına kadar 30 mg dozda aç veya tok alınır; alımını takiben 3 saat içerisinde kusma gerçekleşirse doz tekrarı önerilir. Randomize, çiftkör, faz 2 çalışmada tek doz 50 mg mikronize olmayan UPA (30 mg mikronize UPA'ya eşdeğer) ile 12 saat ara ile iki doz şeklinde alınan 1,5 mg LNG karşılaştırılmış; gebelik oranları UPA grubunda %0,9; LNG grubunda %1,7 bulunmuştur 33 . Aralarındaki fark istatistiksel olarak anlamlı değildir.…”