Progesterone supplementation after ovulation: Effects on corpus luteum function and on fertility of dairy cows subjected to AI or ET

Monteiro, P. L. J.; Nascimento, A. B.; Pontes, G. C. S.; Fernandes, G. O.; Melo, L. G. C.; Wiltbank, Milo C.; Sartori, Roberto

doi:10.1016/j.theriogenology.2015.06.023

Cited by 43 publications

(29 citation statements)

References 62 publications

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“…These findings are similar to those of a previous study, in which dairy cows were treated with a CIDR insert from 3 to 20 days after TAI. In this previous study, the circulating progesterone concentrations were higher in cows with a CIDR insert than in those without one at 4 and 7 days post-insemination, whereas there was no difference in concentration between groups on other days [17]. Our results that the serum progesterone concentration was higher in CIDR-treated cows than non-treated control cows on day 5 are supported by those of other studies [2410].…”

Section: Discussionsupporting

confidence: 89%

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

et al. 2016

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This study investigated the effects of gonadotrophin-releasing hormone (GnRH) administration (Experiment 1) and a controlled internal drug-releasing (CIDR) insert (Experiment 2) after timed artificial insemination (TAI) on the pregnancy rates of dairy cows. In Experiment 1, 569 dairy cows that underwent TAI (day 0) following short-term synchronization with prostaglandin F2α were randomly allocated into two groups: no further treatment (control, n = 307) or injection of 100 µg of gonadorelin on day 5 (GnRH, n = 262). In Experiment 2, 279 dairy cows that underwent TAI (day 0) following Ovsynch were randomly allocated into two groups: no further treatment (control, n = 140) or CIDR insert treatment from days 3.5 to 18 (CIDR, n = 139). The probability of pregnancy following TAI did not differ between the GnRH (34.4%) and control (31.6%, p > 0.05) groups. However, the probability of pregnancy following TAI was higher (odds ratio: 1.74, p < 0.05) in the CIDR group (51.1%) than in the control group (39.3%). Overall, CIDR insert treatment at days 3.5 to 18 increased pregnancy rates relative to non-treated controls, whereas a single GnRH administration on day 5 did not affect the pregnancy outcomes of dairy cows.

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Section: Discussionsupporting

confidence: 89%

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

et al. 2016

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“…Results from various studies have reported an increase (Monteiro et al 2014), no change (Stevenson et al 2007, Monteiro et al 2015 or a decrease (Parr et al 2014) in pregnancy per AI (P/AI) for cows supplemented with exogenous P4 after ovulation compared with untreated controls. Although several studies evaluated the effect of decreasing P4 concentrations after ovulation on the uterine environment and embryo development (Forde et al 2011, few studies have evaluated the effect of decreasing P4 after ovulation on establishment of pregnancy (Kenyon et al 2013, Carvalho et al 2017).…”

Section: Conceptus Size and Progesterone Studiesmentioning

confidence: 99%

Interferon-tau and fertility in ruminants

Forde¹,

Lonergan²

2017

Reproduction

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Establishment of pregnancy in domestic ruminants includes pregnancy recognition signalling by the conceptus, implantation and placentation. Despite the high fertilisation success rate in ruminants, a significant amount of embryo loss occurs, primarily during early gestation. Interferon-tau (IFNT), a type I interferon that is exclusively secreted by the cells of the trophectoderm of the ruminant conceptus, has been recognised as the primary agent for maternal recognition of pregnancy in ruminants. It produces its antiluteolytic effect on the corpus luteum by inhibiting the expression of oxytocin receptors in the uterine epithelial cells, which prevents pulsatile, luteolytic secretion of prostaglandin F2α by the uterine endometrium. While the importance of IFNT in maternal recognition of pregnancy and prevention of luteolysis in ruminants is unequivocal, important questions, for example, relating to the threshold level of IFNT required for pregnancy maintenance, remain unanswered. This paper reviews data linking IFNT with measures of fertility in ruminants. Reproduction (2017) 154 F33-F43

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“…Although E2/P4-based FTAI protocols are widely used in B. taurus and B. indicus (Martinez et al, 2000;Ayres et al, 2008;Meneghetti et al, 2009;Souza et al, 2009;Sá Filho et al, 2011;Pereira et al, 2013b;Monteiro Jr et al, 2015b), the metabolism of E2 is different between B. taurus and B. indicus . For example, in a 3 x 2 Latin Square design study (Bastos et al, 2011), the effect of dose of estradiol benzoate (EB; 1, 2 or 4 mg), given at the same time as a P4 intravaginal insert, on the synchronization of follicular wave emergence was evaluated in non-lactating Nelore (n = 13) and Holstein (n = 11) cows receiving a maintenance diet.…”

Section: Effectiveness Of E2/p4-based Protocols For Follicle Wave Emementioning

confidence: 99%

Endocrine and metabolic differences between Bos taurus and Bos indicus cows andimplications for reproductive management

Sartori

Monteiro

Wiltbank³

2016

Anim Reprod

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Based on the considerable differences in ovarian morphology and function, as well as circulating hormones and metabolites between Bos indicus (B. indicus) and Bos taurus (B. taurus), researchers are using this acquired knowledge to optimize protocols for fixed-time artificial insemination (FTAI), and production of in vivo derived embryos by multiple ovulation or by in vitro embryo production (IVP). In B. indicus, at the time of follicle deviation, the dominant follicle is smaller and acquires ovulatory capacity at a smaller diameter than B. taurus. Moreover, despite ovulating smaller follicles and having smaller corpora lutea (CL), circulating concentrations of estradiol (E2) and progesterone (P4) are greater in B. indicus than B. taurus. These physiological differences may be related to greater circulating cholesterol, insulin and IGF1 in B. indicus than in B. taurus. For both genetic groups there is a negative relationship between circulating P4 and ovulatory response to the first GnRH treatment of a fixed-time AI (FTAI) protocol. Moreover, despite lower clearance rates of steroid hormones in B. indicus than B. taurus, the dose of 2 mg estradiol benzoate seems to be the most effective either for Nelore (B. indicus beef), Angus (B. taurus beef), or Holstein (B. taurus dairy) cows at the initiation of an E2/P4-based FTAI protocol to optimize synchronization and pregnancy per AI (P/AI). Several studies have shown that only one recommended dose of PGF2α at a FTAI protocol may be insufficient for adequate luteolysis in B. indicus and B. taurus. When submitted to multiple ovulation and embryo transfer, B. indicus cows and heifers need less FSH than B. taurus to achieve superovulation. Moreover, IVP has been more successful in B. indicus than B. taurus due to greater antral follicle count and anti-mullerian hormone, and better oocyte quality.

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Progesterone supplementation after ovulation: Effects on corpus luteum function and on fertility of dairy cows subjected to AI or ET

Cited by 43 publications

References 62 publications

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

Interferon-tau and fertility in ruminants

Endocrine and metabolic differences between Bos taurus and Bos indicus cows andimplications for reproductive management

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