Prognosis in Glomerulonephritis

Brahm, M.; Balsløv, Jørgen T.; Brun, Claus; Gerstoft, Jan; Jørgensen, F; Jørgensen, Hans Ejsing; Larsen, Marthe; Larsen, Svend; Lorenzen, I.; Løber, M.; Thomsen, Åge Chr.

doi:10.1111/j.0954-6820.1985.tb01644.x

Journal of Internal Medicine

1985

DOI: 10.1111/j.0954-6820.1985.tb01644.x

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Prognosis in Glomerulonephritis

M. Brahm

Jørgen T. Balsløv

Claus Brun

et al.

Abstract: Between 1967 and 1977, 395 consecutive cases of glomerulonephritis (GN) were collected by a Copenhagen study group. The diagnosis was established by histological and biochemical criteria. Light microscopy investigations of thin silver‐stained sections were applied. In a follow‐up in 1980 all cases were categorized by one of the following end points: death without uremia, uremia, recovery, or censored cases. The course is presented in figures showing the cumulated distribution of outcomes in relation to observa… Show more

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Cited by 4 publications

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Prognostic indicators in patients presenting with the nephrotic syndrome

Hunt¹,

Short²,

Mallick³

1988

Kidney International

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Clinical data from 246 patients presenting with a nephrotic syndrome and biopsy-proven glomerular disorder were analyzed, using statistical survival techniques, to determine which of several variables (sex, age, plasma creatinine, diastolic blood pressure and 24-hour urinary protein loss) were associated with subsequent end-stage renal failure. The best prediction of outcome could be made at one year (N = 121); then plasma creatinine (P less than 0.001) and heavy proteinuria (P = 0.049) were the best determinants. For a given plasma creatinine level, heavy urinary protein was associated with a worse outcome. The incidence of end-stage renal failure was greatest three to four years from the date edema first developed. Plasma creatinine and urinary protein values, collected four-monthly throughout the study period, were analyzed as time-dependent covariates. A relationship was found between the prevailing risk of renal failure and earlier heavy proteinuria (P less than 0.001). Spontaneous complete remission of proteinuria was associated with a highly favorable outcome (P = 0.001) and normal, or impaired but stable, renal function.

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Prognostic indicators in patients presenting with the nephrotic syndrome

Hunt¹,

Short²,

Mallick³

1988

Kidney International

View full text Add to dashboard Cite

show abstract

Prognosis in Glomerulonephritis

Gerstoft

Balsløv

Brahm

et al. 1986

Journal of Internal Medicine

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ABSTRACT. The course of the renal function and mortality were analysed in 395 patients with biopsy‐proven glomerulonephritis (GN), using Cox's proportional hazards model. Seventeen clinical, biochemical and histopathological parameters were analysed for prognostic information. The patients were grouped according to their serum creatinine levels. Increase in serum creatinine, decrease in serum creatinine, cure and death were used as endpoints for the analysis. Caplan Meyer curves were made for 7 transitions between different groups and the variables were reduced by a step‐wise procedure to a final model. Thirteen of the variables considered offered significant prognostic information (p<0.05) for at least one of the transitions. Short duration of disease, young age, non‐nephritic urinary sediment and preceding streptococcal infection were predictors of cure. Extracapillary, membranoproliferative and unclassifiable GN, old age and arterial hypertension predicted increase in serum creatinine in patients with low serum creatinine, while male sex, short duration of disease and pathological electrocardiogram favoured a further increase in patients with high serum creatinine. A later decrease in serum creatinine was signified by a preceding streptococcal infection, short duration of disease, absence of arterial hypertension and low urinary protein excretion. Death without uremia was predicted by high age, connective tissue disease and extracapillary GN. Using these parameters and the models, it is possible to make a prognostic forecast for the individual GN patient. Examples of such a forecast are described.

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Cytostatic Treatment of Glomerular Diseases. V

Brahm

Balsløv

Brammer

et al. 1988

Journal of Internal Medicine

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Abstract. Thirty‐two patients suffering from biopsy‐proven glomerulonephritis with proteinuria ≥1.2 g/24 hours and/or creatinine clearance <50% of normal value were treated for 6 weeks with prednisone plus cyclophosphamide (C+P), azathioprine (A+P) or cyclophosphamide as a monotherapy (C). The effect of the treatment was evaluated after 6 and 16 weeks. The results were entered consecutively in a sequential analysis. The three treatment regimes were compared mutually as well as with the results of 16 weeks' treatment with C and placebo, published previously. Six weeks' treatment with C+P or A+P was superior to C and at least as efficient as 16 weeks' C treatment. C treatment for 6 weeks was less efficient than 16 weeks' C treatment. The side‐effects of the 6 weeks' A+P or C+P treatment were fewer and less serious than those reported from the long‐term C treatment.

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Prognosis in Glomerulonephritis

Cited by 4 publications

References 13 publications

Prognostic indicators in patients presenting with the nephrotic syndrome

Prognostic indicators in patients presenting with the nephrotic syndrome

Prognosis in Glomerulonephritis

Cytostatic Treatment of Glomerular Diseases. V

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