Prognostic Alternative mRNA Splicing in Adrenocortical Carcinoma

Liang, Weiwei; Sun, Fangfang

doi:10.3389/fendo.2021.538364

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…Moreover, this protein contributes to the cytoskeletal reorganization, and to the recovery of the mitochondrial function through its role in different metabolic pathways. In fact, this protein has also been related to the “Wnt signaling pathway” [ 71 ], which, as was previously mentioned, is involved in neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases

Peinado

Ovelleiro

Moral

et al. 2021

IJMS

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Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood–brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value < 0.02; fold change = 0.05) in the infarcted areas showed a total of 219 proteins that significantly changed their expression after stroke and treatment with Ngb-NPs. Of special interest, are proteins such as FBXO7 and NTRK2, which were downexpressed in stroke, but overexpressed after treatment with Ngb-NPs; and ATX2L, which was overexpressed only under the effect of Ngb. Interestingly, the proteins affected by the treatment with Ngb were involved in mitochondrial function and cell death, endocytosis, protein metabolism, cytoskeletal remodeling, or synaptic function, and in regenerative processes, such as dendritogenesis, neuritogenesis, or sinaptogenesis. Consequently, our pharmaceutical preparation may open new therapeutic scopes for stroke and possibly for other neurodegenerative pathologies.

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Section: Discussionmentioning

confidence: 99%

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases

Peinado

Ovelleiro

Moral

et al. 2021

IJMS

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“…Adrenocortical carcinoma (ACC) is a rare cancer type with high malignancy and poor prognosis, particularly for tumors that cannot be fully removed surgically [22,23]. The current TNM classi cation system is inadequate in predicting prognosis for ACC [24], highlighting the need to understand the molecular mechanisms of tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of m7G-Related Signatures in Adrenocortical Carcinoma and Their Correlation with Survival

lin,

Huang,

et al. 2023

Preprint

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N7-methylguanosine (M7G) is a prevalent modification of mRNA in biological systems, and plays a role in various biological processes. Previous research has demonstrated that expression of m7G RNA modification is correlated with cancer and a range of other pathological conditions. The study aimed to explore the potential of m7G as a prognostic biomarker and therapeutic target for Adrenocortical Carcinoma (ACC). A comprehensive analysis was conducted to identify m7G-related genes in ACC by first compiling a list of 26 critical regulators through previous research and Gene Set Enrichment Analysis (GSEA). Subsequently, LASSO Cox regression analysis was performed on RNA-seq data from The Cancer Genome Atlas (TCGA) and accompanying clinical data, resulting in the identification of nine m7G prognostic signatures (GEMIN5, DCPS, AGO2, EIF4E2, NCBP1, WDR4, EIF4A1, EIF4E3, NUDT16) to create a predictive signature. Patients with ACC were then classified into high- and low-risk groups based on the predictive signature, with the results showing that patients in the high-risk group had a poorer prognosis. The m7G signature demonstrated high diagnostic sensitivity and robustness, as demonstrated by its diagnostic performance and external validation through the Gene Expression Omnibus (GEO). This study provides a comprehensive analysis of m7G RNA methylation in ACC and offers insight into the gene expression, function, interaction, and predictive value of m7G-related genes, which may provide valuable information for prognosis prediction and treatment guidance for ACC patients.

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“…Liang and Sun , in their contribution to “Prognostic Alternative mRNA Splicing in Adrenocortical Carcinoma,” their data provided a comprehensive bioinformatics analysis of alternative splicing (AS) events in Adrenocortical Carcinoma (ACC) after they constructed well-performed prognostic predictors for risk stratification in ACC. Their study provided biomarkers for disease progression and a potentially rich source of novel therapeutic targets, and this convinced them that these findings could contribute to clinical cancer management as it provided a comprehensive bioinformatics analysis of AS events in ACC, providing biomarkers for disease progression and a potentially rich source of novel therapeutic targets ( 15 ).…”

Section: Highlights From Research Topic Contributionsmentioning

confidence: 99%

Editorial: The RNA revolution and cancer

Dlamini,

Ladomery,

Kahraman

2024

Front. Endocrinol.

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RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Processes like alternative splicing and noncoding RNA regulation shape cancer biology, with microRNAs, long noncoding RNAs, and circular RNAs orchestrating gene expression dynamics. Aberrant RNA signatures hold promise as diagnostic and prognostic biomarkers in endocrine-related cancers. Recent findings, such as aberrant PI3Kδ splice isoforms and epithelial-mesenchymal transition-related lncRNA signatures, unveil potential therapeutic targets for personalized treatments. Insights into m6A-associated lncRNA prognostic models and the function of lncRNA LINC00659 in gastric cancer represents ongoing research in this field. As understanding of RNA's role in cancer expands, personalized therapies offer transformative potential in managing endocrine-related malignancies. This signifies a significant stride towards precision oncology, fostering innovation for more effective cancer care.

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Prognostic Alternative mRNA Splicing in Adrenocortical Carcinoma

Cited by 6 publications

References 46 publications

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases

Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases

Analysis of m7G-Related Signatures in Adrenocortical Carcinoma and Their Correlation with Survival

Editorial: The RNA revolution and cancer

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