Prognostic analysis of different pathological types of uterine sarcoma

Abstract

Purpose There is a high recurrence rate and poor prognosis of uterine sarcomas, which are rare and aggressive gynecologic malignancies. Therefore, the study aims to examine the clinicopathological characteristics and prognostic factors associated with different histology types of uterine sarcomas. Method This study is a retrospective study. The clinical data of 80 patients (40 patients of uterine leiomyosarcom (ULMS) and 40 patients of endometrial stromal sarcomas (ESS)) treated at Chunliu Hospital of Dalian Women and Children's Center (group) over the past ten years were collected. A follow-up was conducted for all patients. For revealing the prognostic factors for different pathological types, SPSS25.0 statistical software was used to analyze the data retrospectively. Results Among the ULMS patients, univariate analysis showed that the postmenopausal patients had poor survival results (P = 0.025). While the patients with lower tumor stage (P = 0.000), tumor size ≤ 5 cm (P = 0.012), Ki-67 expression ≤ 10% (P = 0.012), PR expression negative (P = 0.007) and without lymph node resection (P = 0.049) had better survival results. Among the ESS patients, univariate analysis showed that postmenopausal patients with a higher tumor stage (P = 0.026) and those with tumor > 5 cm (P = 0.007) had poorer survival results. Multivariate analysis showed that surgical stage and tumor size are independent prognostic and survival indicators for ULMS, while menopause is an independent prognostic and survival indicator for ESS. Conclusion Multiple factors can affect the prognosis of uterine sarcoma. However, tumor size, and tumor stage, are independent risk factors for ULMS and menopause status is an independent risk factor for ESS prognosis.