Prognostic and predictive factors in patients with metastatic gastric cancer treated with immune checkpoint inhibitors
A. B. Rays,
M. Yu. Fedyanin,
D. V. Popov
et al.
Abstract:Introduction. Microsatellite instability, PD-L1 CPS expression, high tumor mutational burden (TMB), and the presence of Epstein-Barr virus are the main tumor predictors of the response to immunotherapy in patients with metastatic gastric cancer (mGC). However, selecting patients for immunotherapy in mGC seems challenging due the lack of an optimal cut-off for PD-L1 CPS expression in microsatellite-stable gastric adenocarcinomas, significant benefit from anti-PD-L1 inhibitors in late-line treatment, and inacces… Show more
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