Prognostic and Predictive Role of Angiogenic Markers in Non- Small Cell Lung Cancer

Keskın, Serkan; Kutluk, Ali Cevat; Taş, Faruk

doi:10.31557/apjcp.2019.20.3.733

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…IL‐8 has been observed to be associated with worse disease prognosis in pancreatic cancer, ovarian cancer, breast cancer and NSCLC. 17 , 18 , 19 , 20 Our results contribute to the literature in the era of chemoimmunotherapy.…”

Section: Discussionsupporting

confidence: 60%

Circulating cytokines associated with clinical outcomes in advanced non‐small cell lung cancer patients who received chemoimmunotherapy

Shi

Liu

et al. 2021

Thoracic Cancer

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Background: Pretreatment and on-treatment plasma cytokine levels in predicting clinical benefit in patients with advanced non-small cell lung cancer (NSCLC) treated with anti-programmed death-1 (PD-1)-based chemotherapy is still a matter of debate. Methods: We measured 12 kind of plasma cytokines in patients with stage III/IV NSCLC before and during treatment with anti-PD-1 based chemotherapy. Associations with best overall response, and survival including progression-free survival (PFS) and overall survival (OS) were assessed using Chi-square test and Kaplan-Meier plots with log-rank test, respectively. Logistic regression and Cox regression were used to determine independent risk factors. Results: Of a total of 60 patients, high-level of pretreatment interleukin-2 was associated with longer PFS (log rank p = 0.049), while high-level of pretreatment interleukin-8 was associated with shorter OS (log rank p = 0.006). Increased ontreatment interleukin-1β (IL-1β) was associated with both better response (odds ratio [OR] 6.233, 95% confidential interval [CI]: 1.451-26.344, p = 0.013) and longer PFS (hazard ratio [HR] 0.305, 95% CI: 0.127-0.730, p = 0.008). On the contrary, increased on-treatment interleukin-6 (IL-6) was associated with a worse response (OR 0.015, 95% CI: 0.001-0.400, p = 0.012), worse PFS (HR 2.639, 95% CI: 1.163-5.991, p = 0.020) and worse OS (HR 2.742, 95% CI: 1.063-7.074, p = 0.037). Increased interferon-γ (IFN-γ) was found to be associated with better PFS (HR 0.336, 95% CI: 0.153-0.745, p = 0.007). Conclusions: In patients with advanced NSCLC who received chemoimmunotherapy, on-treatment increased IL-1β and IFN-γ may serve as positive indicator of efficacy, while on-treatment increased IL-6 might play a predictive role of worse clinical outcome. K E Y W O R D Sadvanced non-small cell lung cancer, chemoimmunotherapy, cytokines, interleukin-1β, interleukin-6 Yuequan Shi, Xiaoyan Liu, and Juan Du contributed equally to this study.

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Section: Discussionsupporting

confidence: 60%

Circulating cytokines associated with clinical outcomes in advanced non‐small cell lung cancer patients who received chemoimmunotherapy

Shi

Liu

et al. 2021

Thoracic Cancer

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“…A higher IL-8 expression was also investigated in other neoplasms. Its elevated serum concentration has also been reported, among others, in breast, prostate, and lung cancer [ 20 , 21 , 22 , 23 ]. An increased level of IL-8 was also present in the peritoneal fluid aspirated from patients with ovarian malignancies [ 24 ].…”

Section: Introductionmentioning

confidence: 89%

The Clinical Importance of IL-6, IL-8, and TNF-α in Patients with Ovarian Carcinoma and Benign Cystic Lesions

Pawlik

Kozłowski

et al. 2021

Diagnostics

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The exact pathogenesis and influence of various cytokines in patients with ovarian lesions remains unclear. Hence, this study aimed to investigate whether IL-6, IL-8, and TNF-α could be considered as new useful markers for diagnosis of ovarian cancer. 63 women diagnosed with ovarian cancer (OC) and 53 patients with benign ovarian cystic (BOC) lesions were included in this study. Serum levels of IL-6, IL-8, and TNF-α were measured using ELISA. Statistical comparisons were made using the Mann–Whitney U test and all correlations were evaluated by Spearman’s ranks. The serum IL-8 and TNF-α concentration measured in the OC Group was significantly higher than in the BOC Group (p < 0.05). The cutoff level of IL-8 and TNF-α in the serum was set at 4.09 ng/mL and 2.63 ng/mL, respectively, with the sensitivity and specificity of 70% and 96% for IL-8 and 85.7% and 79.3% for TNF-α (p < 0.0001). These results suggest that IL-8 and TNF-α are useful biomarkers for predicting the malignant character of lesions of the ovary. The present study highlighted the importance of measuring the cytokines such as IL-8 and TNF-α in patients with ovarian lesions in predicting the clinical outcome.

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“…Immature and structural disorders of vascular endothelial cells are the main reason for tumor hypoxia, and their discontinuities are also the morphological basis for tumor cells entering the vasculature to metastasize (Kerbel 2008). However, many con icting results have been reported regarding the prognostic signi cance of TAMs and tumor neo-vessels in NSCLC (Becker et al 2014;Du et al 2015;Keskin et al 2019;Zhang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The impact of the molecular profile of the tumor microenvironment on the prognosis of NSCLC

Ying

Qin

Cheng

et al. 2021

Preprint

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Purpose The present study was performed to clarify the correlation between macrophages, tumor neo-vessels and programmed cell death-ligand 1 (PD-L1) in the tumor microenvironment (TME) and the clinicopathological features of non-small cell lung cancer (NSCLC) and to explore the prognostic factors of stromal features in NSCLC. Methods Tissue microarrays containing 92 NSCLC patients were studied with immunohistochemistry (IHC). The distribution and quantitative data of CD68- and CD206-positive tumor-associated macrophages (TAMs) in tumor islets and tumor stroma, and the expression of tumor neo‑vessels and PD-L1, were analyzed by inverted microscopy and Image-Pro Plus 6.0 software. Prognostic analyses with the clinicopathological characteristics and tumor microenvironment features were performed. Results The number of CD68-positive macrophages in each location of the tumor islets and tumor stroma was significantly higher than that of CD206-positive macrophages, and they were significantly correlated (P < 0.0001). Survival analysis revealed that CD68- and CD206-positive TAMs in the tumor stroma and tumor islets were significant prognostic factors (P < 0.05, respectively). Comprehensive analysis of CD206-positive stromal TAMs showed that CD105 and PD-L1 were significant prognostic factors (P=0.045). Moreover, CD68-positive TAMs in tumor islets and the expression of PD-L1 were independent predictors of poor prognosis for NSCLC. Conclusion Thus, the key elements in the tumor microenvironment, including tumor neo‑vessels, macrophages and PD-L1, were heterogenic in NSCLC tissues and had significant roles in cancer invasion and metastasis. The combined analysis of key components in the tumor microenvironment was an important prognostic factor.

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Prognostic and Predictive Role of Angiogenic Markers in Non- Small Cell Lung Cancer

Cited by 11 publications

References 12 publications

Circulating cytokines associated with clinical outcomes in advanced non‐small cell lung cancer patients who received chemoimmunotherapy

Circulating cytokines associated with clinical outcomes in advanced non‐small cell lung cancer patients who received chemoimmunotherapy

The Clinical Importance of IL-6, IL-8, and TNF-α in Patients with Ovarian Carcinoma and Benign Cystic Lesions

The impact of the molecular profile of the tumor microenvironment on the prognosis of NSCLC

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