Prognostic Factors Affecting the Outcome of Nasopharyngeal Carcinoma

Liu, Mu-Tai; Hsieh, Chang‐Yao; Chang, Tse Wen; Lin, Jao-Perng; Huang, Chia‐Wei; Wang, Ai-Yih

doi:10.1093/jjco/hyg092

Cited by 99 publications

(81 citation statements)

References 35 publications

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“…Although the differences between node stage and sex subgroups in terms of OS were not statistically significant, trends toward significance were observed. These findings are consistent with results of most other studies (4,10,14). In conclusion, our study provides some evidence on the outcome of Iranian patients with nasopharyngeal cancer and factors influencing it.…”

Section: Discussionsupporting

confidence: 93%

“…Liu et al evaluated 83 patients with non-metastatic nasopharyngeal carcinoma treated with intensity modulated radiation therapy (IMRT) with or without chemotherapy and analyzed the factors influencing their outcome. Three-year OS of the patients was 82% and stage of disease, N-classification and cumulative dose to primary tumor were significant prognostic factors for overall survival (10). In another study in China, Wang et al showed three-year overall survivals of 83% and 88% among Uyghur and Han patients, respectively.…”

Section: Discussionmentioning

confidence: 94%

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Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran

et al. 2017

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Background: Evidence about survival of the patients with nasopharyngeal cancer is scant in our region and the aim of the current study was to determine clinico-pathological factors influencing outcome of these patients. Methods:We reviewed all patients with a new diagnosis of nasopharyngeal carcinoma admitted between 2008 and 2014 to Jorjani cancer center, Tehran, Iran. Overall survival (OS) of the patients and their relation with demographic and clinico-pathological factors were analyzed. Results:Of 88 included patients, 56 were male and 32 were female with mean age of 46 years. With a median follow-up period of 31 months (range: 3 to 86 months), the overall survival of the whole patients and those without distant metastasis were 64% and 67% respectively. Tumor stage and presence or absence of distant metastasis at presentation were the only parameters that significantly influenced the patients' OS. Conclusions:Our study provides some evidence on the outcome of Iranian patients with nasopharyngeal cancer and factors influencing it.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran

et al. 2017

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“…Moreover this issue is complicated by the fact that the radiation dose required to eradicate tumor from nasopharynx are far more than what is considered to be the tolerance limit of surrounding normal structures (Liu et al, 2003). To address these challenges 2 dimensional radiotherapy techniques, that has been used traditionally, was replaced by three dimensional conformal radiotherapy (3DCRT) (Teo et al, 2004).…”

Section: Plan Dose Evaluation Of Three Dimensional Conformal Radiothementioning

confidence: 99%

Plan Dose Evaluation of Three Dimensional Conformal Radiotherapy Planning (3D-CRT) of Nasopharyngeal Carcinoma (NPC): Experience of a Tertiary Care University Hospital in Pakistan

Abbası

Hafiz²,

Nasir³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The 5-year OS rate of all 53 patients was 25.5%, and the 5-year OS rate of the 24 patients treated by IMRT was 45.5%. These rates were significantly decreased compared with the OS rate of patients with local advanced NPC (T3-T4) (2,3,(11)(12)(13)(14)(15). Previous studies have also revealed that prevertebral space invasion was an independent prognostic factor in patients with NPC that were treated by IMRT (4,16,17).…”

Section: Discussionmentioning

confidence: 93%

Analysis of the efficacy of intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in nasopharyngeal carcinoma with involvement of the cervical spine

et al. 2015

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Abstract. The aim of the present study was to retrospectively analyze the clinical efficacy and side-effects of two-dimensional conventional radiotherapy (2D-CRT) and intensity-modulated radiotherapy (IMRT) in 53 NPC patients with cervical spine involvement, without distant metastases. In total, 53 patients were enrolled in the present study, with 24 being treated with IMRT and 29 being treated with 2D-CRT. All 53 patients received platinum-based concurrent chemotherapy and 4-6 cycles of adjuvant chemotherapy subsequent to radiation. The patients were clinically staged according to the seventh edition of the UICC and AJCC staging systems. Overall survival (OS), local progression-free survival (LPFS) and distant metastasis-free survival (DMFS) rates were calculated. The 3-and 5-year OS rates were 87.7% and 45.5% in the IMRT-treated group and 65.5% and 9.1% in the 2D-CRT-treated group (P=0.01). The 3-and 5-year LPES rates were 87.4% and 69.9% in the IMRT-treated group compared with 49.4% and 9.4% in the 2D-CRT-treated group, respectively (P=0.00). The 3-and 5-year DMFS rates were 94.4 and 40.8% in the IMRT-treated group and 79.8 and 30.4% in the 2D-CRT-treated group (P=0.13). N stage (P=0.00) and radiotherapy methods (P=0.01) were relevant to the OS and LPFS rates, it also revealed a significant difference when the DMFS rates were analyzed in N stage. The incidence of dry mouth in the IMRT group was significantly lower (P=0.01), but there was no statistically significant difference in acute oropharyngeal mucositis or myelosuppression. IMRT had significant advantages in local control and OS compared with conventional 2D-CRT, but IMRT failed to reduce the incidence of distant metastasis.

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Prognostic Factors Affecting the Outcome of Nasopharyngeal Carcinoma

Cited by 99 publications

References 35 publications

Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran

Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran

Plan Dose Evaluation of Three Dimensional Conformal Radiotherapy Planning (3D-CRT) of Nasopharyngeal Carcinoma (NPC): Experience of a Tertiary Care University Hospital in Pakistan

Analysis of the efficacy of intensity-modulated radiotherapy and two-dimensional conventional radiotherapy in nasopharyngeal carcinoma with involvement of the cervical spine

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