Prognostic factors after surgical resection for pancreatic carcinoma

Magistrelli, Paolo; Antinori, Armando; Crucitti, Antonio; Greca, Antonio La; Masetti, Riccardo; Coppola, Roberto; Nuzzo, Gennaro; Picciocchi, Aurelio

doi:10.1002/1096-9098(200005)74:1<36::aid-jso9>3.0.co;2-f

Cited by 60 publications

(49 citation statements)

References 16 publications

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“…The patients characteristics such as gender, age, and 5-year survival rates were similar to those in the previous studies from Japan (5,6) and Western countries (7). The present uni-and multivariate analyses confirmed the prognostic significance of tumor differentiation and T-factor for the pathological TumorNode-Metastasis classification of PDAC, as previously reported (5, 7).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma

Yamamoto¹,

Tomita

Hoshida

et al. 2004

Clinical Cancer Research

222

153

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Purpose: Akt is a serine/threonine kinase that plays a central role in tumorigenesis. Among the members of Akt family, Akt2 is associated with the development of human cancers. The present study was designed to clarify the prognostic significance of Akt2 and activated Akt expression in pancreatic ductal adenocarcinoma (PDAC). In addition, activated extracellular signal-regulated kinase 1 and 2 (ERK1/2) and the proliferation activity of tumor cells detected by Ki-67 immunohistochemistry were examined.Experimental Design: Immunohistochemical analysis was performed on paraffin-embedded specimens from 65 patients with PDAC; 36 males and 29 females with ages ranging from 48 to 79 years (median, 66 years) of age. Expression levels of Akt2, phosphorylated Akt (p-Akt), and phosphorylated ERK 1/2 (p-ERK 1/2) were categorized as either weaker (low intensity) or equal to stronger (high intensity) compared with those in the endothelial cells of the same specimens. For Ki-67 immunohistochemistry, cases were divided into two groups: level 1, Ki-67 labeling index (LI), <20%; level 2, Ki-67 LI, >20%.Results: Twenty-six (42.6%), 28 (45.9%), 39 (63.9%), and 46 (75.4%) of the tumors showed high intensity of Akt2, p-Akt, and p-ERK 1/2 expression, and Ki-67 LI level 2, respectively. A significant positive correlation was observed between Akt2 and p-Akt expression (P < 0.01). Multivariate analysis revealed that p-Akt expression, Ki-67 LI, and histological differentiation are independent prognosticators for PDAC.Conclusions: p-Akt expression is a significant prognostic indicator for PDAC. Inhibition of Akt is a possible molecular approach for treatment of PDAC.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma

Yamamoto¹,

Tomita

Hoshida

et al. 2004

Clinical Cancer Research

222

153

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“…8,[30][31][32] Finally, 18 articles were included after reading the full papers (Table 1). 4,[15][16][17][18][19][33][34][35][36][37][38][39][40][41][42][43][44] …”

Section: Search Strategy and Study Identificationmentioning

confidence: 99%

“…4,[17][18][19][34][35][36]44 Peri-operative mortality or mortality within 30 days of the date of operation was found to be 2.12% (N=117) in 13 studies providing this data with total of 5512 patients. [34][35][36]41 including 504 patients compared data of 3-year survival rates. Three year survival rate of 25.6% and 14.36% was seen with tumor size <3 cm and >3 cm respectively and the result being statistically significant (P<0.01) (Table 3).…”

Section: Systematic Review Operation Intra-operative and Post-operatmentioning

confidence: 99%

“…Three year survival rate of 25.6% and 14.36% was seen with tumor size <3 cm and >3 cm respectively and the result being statistically significant (P<0.01) (Table 3). Finally, a total of 5 studies 18,19,35,36,41 with 958 patients provided data on 5-year survival rates. 5-year survival rate of 23.72% and 9.70% was seen with tumor size <3 cm and >3 cm respectively and the result being statistically significant (P<0.001) ( Table 3).…”

Section: Systematic Review Operation Intra-operative and Post-operatmentioning

confidence: 99%

“…As no heterogeneity among studies was seen (p=0.31), fixed effect was used. (Figure 3 a) 3 cm cut-off point and survival outcome Similarly, 6 studies 18,19,35,36,41,42 were reported to provide data on effect estimate assessing tumor size with 3 cm cut-off. The combined HR of the tumor size with 3 cm cut-off was 1.35 with 95% CI of [0.86-2.13], I 2 = 85%, p=0.19 (p-value not significant).…”

Section: Meta-analysis Publication Biasmentioning

confidence: 99%

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Impact of tumor size on survival outcome of pancreatic carcinoma following pancreatic resection: A systematic review and meta-analysis

Shrestha

Baskota

et al. 2018

Asian J Med Sci

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A B S T R A C T REVIEW ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCESThe aim of the study was to evaluate the influence of tumor size on long-term survival outcome of pancreatic tumors following pancreatic resection and the possibility of implementing another tumor size cut-off point in AJCC pancreatic tumor staging. Literature searches was conducted on electronic database to identify relevant studies on tumor size related survival outcome following pancreatic resection for pancreatic adenocarcinoma. Meta-analysis was done using the effect estimates and the use of 95% confidence intervals (CIs) was done to calculate the pooled risk estimates; heterogeneity among studies was examined using I 2 statistic. Total of 18 trials (13 retrospective and 5 prospective studies) including 6230 elderly patients was included in this study. The pooled HR of the tumor size with 2 cm cut-off was 1.43 with 95% CI of [1.27-1.62], I 2 = 17%, p<0.00001 and was statistically significant. Median survival for tumor size <2, >2, <3, >3, <4 and >4 were 41.02 months, 16.20 months, 19.41 months, 10.79 months, 24.2 months and 15.14 months respectively and the 1-, 3-, and 5-year survival rate decreased with increasing tumor diameter. Importantly, a total of four studies results indicated that 3-year survival rate and a total of five studies results indicated that 5-year survival rate had statistical significance with 3 cm cut-off. Tumor diameter of 2 cm seems to be a reasonable but relatively less comprehensive cut-off point. 3 cm cut-off maybe become a new potential tumor size cut-off point in addition to the current sole 2 cm cut-off point defining tumor stage.

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Significance of the Depth of Portal Vein Wall Invasion After Curative Resection for Pancreatic Adenocarcinoma

Fukuda

Oussoultzoglou²,

Bachellier³

et al. 2007

Arch Surg

110

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Prognostic factors after surgical resection for pancreatic carcinoma

Abstract: T and nodal stage are the strongest independent predictors of survival. Limited intraoperative transfusion, reduced operative time, and clear margins also may play a role, which requires further confirmation in a larger series.

Cited by 60 publications

References 16 publications

Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma

Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma

Impact of tumor size on survival outcome of pancreatic carcinoma following pancreatic resection: A systematic review and meta-analysis

Significance of the Depth of Portal Vein Wall Invasion After Curative Resection for Pancreatic Adenocarcinoma

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