Prognostic Factors Analysis for Colon Cancer with Lymph Node Negative

Abstract

We performed a retrospective analysis regarding the impact of prognosis factors for patients with high recurrence risk in stages I and II. We studied 99 patients with T2, T3 and T4 tumors who suffered a curative resection and whom may or may not present indication for adjuvant chemotherapy according to histoprognostic factors and molecular biomarkers. We performed a univariate Cox regression which highlighted that male sex is a risk factor for disease relapse (HR=5.53, p 0.05, IC95% = 1.29 to 23.73). Although with a low statistical significance effect, T4 tumors seems to be associated with a poor prognosis regarding disease relapse (HR = 2.56, p = 0.06, IC95% = 0.94 to 6.99) compared to T2 and T3 tumors. Patients with d'MMR (MSI-H) seem to have a more favorable evolution compared to patients with p'MMR (MSS/MSI-L) - HR (d'MMR vs p'MMR) = 0.19, IC95% = 0.02 to 1.61, p = 0.13. We believe that it would be useful for MSS / MSI to be systematically analyzed, our data suggesting a better response of d`MMR patients to adjuvant chemotherapy. The multivariate Cox regression did not identify independent risk factors of relapse.

The impact of lymphovascular invasion on recurrence-free survival in high-risk stage II colorectal cancer patients treated with adjuvant therapy.

“…In some studies, different clinicopathologic features, such as T4 tumor, low count lymph node evaluation, high-grade tumor, male gender, bowel obstruction, presence of LVI or PNI, and high preoperative CEA, have been linked to a high possibility of death and recurrence (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Preoperative Predictors of Lymph Node Metastasis in Colon Cancer

“…LNM in colon cancer can be predicted by histopathological markers. Tumor stage and grade are well-recognized predictors (10)(11)(12). However, in clinical practice, statistical results cannot be directly applied to individual clinical diagnosis and treatment.…”