Prognostic factors and recurrence pattern in node-negative advanced gastric cancer

Kim, Beom Su; Yook, Jeong-Hwan; Kim, T.H.; Kim, H.S.; Kim, K.C.; Oh, Shimei; Kim, B.S.

doi:10.1016/j.ejso.2012.10.008

Cited by 29 publications

(19 citation statements)

References 19 publications

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“…Risk factors for peritoneal metastasis such as depth of tumor invasion and lymph node metastasis are related to high 18 F-FDG uptake (13,16,29). In contrast, tumors with diffuse type of Lauren classification and Bormann classification type 4 that show low 18 F-FDG uptake are also risk factors for peritoneal recurrence (5,7,9,13,21,28,31). Further, the high peritoneal recurrence rate in signet-ring cell carcinoma/ mucinous adenocarcinoma, which is known to have low 18 F-FDG uptake, could have contributed to the results of this study (9,13,21).…”

Section: Discussionmentioning

confidence: 99%

“…Although previous studies showed no difference in prognosis between peritoneal recurrence and distant metastasis (8,25,26), the evaluation of risk factors for peritoneal recurrence and distant metastasis could improve selection of treatment and follow-up strategies. Depth of tumor invasion, lymph node metastasis, tumor size, Lauren classification diffuse type, undifferentiated cancer, and Bormann classification type 4 are independent risk factors for peritoneal recurrence (5,7,8,25,27,28). Meanwhile, depth of tumor invasion, lymph node metastasis, venous invasion, and Lauren classification intestinal type were determined to be independent risk factors for distant metastasis (5,8,25,28).…”

Section: Discussionmentioning

confidence: 99%

“…Depth of tumor invasion, lymph node metastasis, tumor size, Lauren classification diffuse type, undifferentiated cancer, and Bormann classification type 4 are independent risk factors for peritoneal recurrence (5,7,8,25,27,28). Meanwhile, depth of tumor invasion, lymph node metastasis, venous invasion, and Lauren classification intestinal type were determined to be independent risk factors for distant metastasis (5,8,25,28). Similar to the previous studies, we also found that pT stage, lymph node metastasis, Bormann type 4, and Lauren classification nonintestinal type were independent risk factors for peritoneal recurrence, whereas lymphovascular invasion was an independent risk factor for distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Lee

Cho

et al. 2015

J Nucl Med

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This study evaluated the predictive value of 18 F-FDG PET for distant metastasis-free survival and peritoneal recurrence-free survival as well as recurrence-free survival and overall survival after curative surgical resection in patients with advanced gastric cancer (AGC). Methods: Two hundred seventy-nine patients with AGC who underwent preoperative 18 F-FDG PET and subsequent curative surgical resection were included. The tumor-to-normal liver uptake ratio (TLR) of cancer lesions was measured, and the prognostic significance of TLR and tumor factors for distant metastasis-free survival, peritoneal recurrencefree survival, recurrence-free survival, and overall survival was assessed. Results: The 5-y recurrence-free survival, peritoneal recurrence-free survival, distant metastasis-free survival, and overall survival rates were 46.9%, 68.5%, 76.0%, and 58.1%, respectively. Depth of tumor invasion, lymph node metastasis, lymphovascular invasion, and TLR were independent prognostic factors for both recurrence-free survival and overall survival (P , 0.05). For distant metastasis-free survival, lymphovascular invasion and TLR were independent risk factors (P , 0.05). In patients with a TLR of 2.0 or less, the 5-y distant metastasis-free survival rate was 95.5%; in patients with a TLR greater than 2.0, the 5-y distant metastasis-free survival rate was 68.8%. For peritoneal recurrence-free survival, TLR showed no statistical significance (P 5 0.7) whereas pT stage, lymph node metastasis, Lauren classification, and Bormann type were independent prognostic factors (P , 0.05). Conclusion: 18 F-FDG uptake of AGC is an independent prognostic factor for distant metastasis-free survival, recurrence-free survival, and overall survival. The possibility of distant metastasis during follow-up should be considered in patients with high 18 F-FDG uptake.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Lee

Cho

et al. 2015

J Nucl Med

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“…5-year survival of the four groups classified by differentiation and depth of penetration in layers is [T2/3 (differentiated type), T2/3 (undifferentiated type), T4a (differentiated type), and T4a (undifferentiated type)] were 98%, 92%, 80%, and 72%, respectively (P < 0.01) [15]. Inhibitory effects on cell Ca growth of the stomach have antioxidant substances like: CFPS-2 containing: Glucosamin, glucose, Galactose, Fructose, protein and sulfate groups [16]. Our case is sent for chemotherapy treatment after consular decision and consultation with oncologist.…”

Section: Discussionmentioning

confidence: 99%

Presentation of signet ring cell type at carcinoma ventriculi of the patient aged 20 years old

Avdaj¹,

Gözalan²,

Hyseni³

et al. 2013

CRCM

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Introduction: Diffuse variant of GC is composed of gastric-type mucous cells, which generally do not form glands, but rather permit the mucosa and wall as scattered individual cells or small clusters in an "infiltrative" growth pattern. These cells appear to arise from the middle layer of the mucosa, and the presence of intestinal metaplasia is not a prerequisite. In this version, mucin formation expands the malignant cells and pushes the nucleus to the periphery, creating a "signet ring" conformation. If the signetring cells are more than 50% of the tumor, the tumor is classified as signetring cell carcinoma [1]. This case is important for reporting because we encountered for the first time such a carcinoma type, due to the new age and its atypical presentation. Case Presentation: We report a case of a 20 years Albanian old patient with Signet Ring Cell Type of Gastric CA. The patient was brought at the urgency with severe abdominal pain, nausea and peritoneal irritation. Clinical examination has been made in emergency, where we conclude the signs of peritoneal irritation, from native Ro no signs of pneumoperitoneum, while laboratory tests found a slight anemia (erythrocytes 3.36, HCT 25, HGB 8.6). Two hours later we repeated the native RTG and there were present the signs of pneumoperitoneum. It was indicated urgent surgical intervention. Intraoperatively, we found Ulcer duodenal perforation and undertook the operation procedures by Roscoe Graham technique. Conclusions: At this age, it is rare, and it is difficult to detect in its early stages, because the signs and symptoms are often non-existent, non-specific, or mimic as an ulcer. The most common symptoms are early heartburn indigestion, abdominal pain or discomfort, vomiting, constipation, diarrhea or to feel of filling after a small meal, loss of appetite, weakness and fatigue. Less common symptoms are anemia and weight loss.

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“…Tumor diameter, lymphatic invasion, venous invasion, etc., have been considered as prognostic factors in patients with T3N0 gastric cancer (2)(3)(4)(5)(6). Opinions regarding the prognostic factors are divided, and no consensus has been reached.…”

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confidence: 99%

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

Nakamura

Tomioku

Nabeshima

et al. 2017

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Abstract. Background: The aim of this study was to clarify the impact of the horizontal width of tumor invasion into the subserosal layer on prognosis in patients withIn Japan, gastric cancer is treated according to the Japanese gastric cancer treatment guidelines 2014 (1). According to the guidelines, the standard treatment for curatively resectable advanced gastric cancer with invasion of the subserosa (T3) and no lymph node metastasis (N0) is surgery alone. However, a certain proportion of these patients develop recurrence, and nearly all patients with recurrence die of their disease. Therefore, it is considered to be of crucial clinical importance to identify the subset of patients with poor prognosis in this group.Tumor diameter, lymphatic invasion, venous invasion, etc., have been considered as prognostic factors in patients with T3N0 gastric cancer (2-6). Opinions regarding the prognostic factors are divided, and no consensus has been reached. Therefore, in this study, we paid attention to the status of tumor invasion at the invasive front. Many studies of the status of tumor invasion at the invasive front have investigated changes in the serosal surface in patients with gastric cancer invading the serosa (7-10). However, there have been few studies investigating the status of tumor invasion into the subserosal layer in gastric cancer with invasion of the subserosa (11). Therefore, in the present study, we assessed the status of tumor invasion into the subserosal layer in T3N0 gastric cancer and investigated the possibility of its being a prognostic factor. Patients and MethodsPatients. Between January 2006 and December 2015, 884 consecutive patients with gastric cancer underwent curative gastrectomy at the Department of Gastroenterological Surgery of Tokai University School of Medicine. Of these patients, the data of 72 in whom the histological examination revealed pT3N0 were analyzed in this retrospective study. The gross classification and histopathological classification were based on the Japanese Classification of Gastric Carcinoma published by the Japanese Gastric Cancer Association (JCGC) (12). Staging was performed according to the American Joint Committee on Cancer staging manual seventh edition (13). Patients were mainly followed-up on an outpatient basis at our hospital; however, those who had moved to other institutions were asked relevant questions by telephone. Follow-up was continued until June 2016, with a median duration of follow-up of 1574 days (range=82-4373 days). Diagnosis of tumor recurrence was based on clinical grounds. In patients with suspected recurrence, further investigations were performed. In some patients, the initial recurrence was diagnosed at two or more sites, and in such patients, all of the sites were counted as sites of initial recurrence.Definition of width of subserosal invasion and clinicopathological parameters. The resected stomach was opened and placed on a flat board with the mucosal side up, and fixed in 10% formalin. After 409

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Prognostic factors and recurrence pattern in node-negative advanced gastric cancer

Cited by 29 publications

References 19 publications

Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Presentation of signet ring cell type at carcinoma ventriculi of the patient aged 20 years old

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

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Prognostic factors and recurrence pattern in node-negative advanced gastric cancer

Cited by 29 publications

References 19 publications

Relationship Between 18F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Relationship Between 18F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Presentation of signet ring cell type at carcinoma ventriculi of the patient aged 20 years old

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

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Product

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Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer

Relationship Between ¹⁸F-FDG Uptake on PET and Recurrence Patterns After Curative Surgical Resection in Patients with Advanced Gastric Cancer