Prognostic factors for brain metastasis in women presenting cervical cancer

Rangel, Juliana de Brito; Giglio, Alessandra Grasso; Cardozo, Cristiane Lemos; Bergmann, Anke; Thuler, Luiz Cláudio Santos

doi:10.1007/s11060-022-04082-9

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…It is well known that brain metastasis from CSCC is rare but highly lethal. [ 14 , 15 ] The median survival from the diagnosis of brain metastasis to death is as less as 2.3 months. [ 14 ] Our results were similar to those of other studies, indicating that brain metastasis was an important factor affecting the prognosis of CSCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 14 ] Our results were similar to those of other studies, indicating that brain metastasis was an important factor affecting the prognosis of CSCC patients. [ 15 , 16 ] Lung is the main metastasis organ of CC, and the probability of lung metastasis is about 4.16% to 7.70%. [ 14 , 17 ] As expected, lung metastasis was also identified as the powerful prognostic factor for OS and CSS in this study.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database

Ding

Zhou

et al. 2023

Medicine

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Cervical squamous cell carcinoma (CSCC) is the most common histological type of cervical cancer (CC). And mCSCC is the end stage of CSCC. The aim of this study was to develop prognostic nomograms that provide better predictions for overall survival (OS) and cancer-specific survival (CSS) in mCSCC patients. Data from patients with initially diagnosed mCSCC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. The nomograms for OS and CSS were constructed based on Cox regression analysis. The validation of the newly established nomograms was evaluated by concordance index (C-index), calibration curves, and decision curve analyses (DCAs). A total of 2198 patients with mCSCC were included and randomly split into training (n = 1539) and validation (n = 659) cohorts in a 7:3 ratio. Multivariate analyses revealed that the prognostic variables significantly related to the OS and CSS were marital status, T stage, brain metastasis, lung metastasis, tumor size, number of positive lymph nodes, chemotherapy, and radiotherapy. The nomograms were constructed based on these factors. The C-index value of the nomograms for predicting OS and CSS was 0.714 and 0.683, respectively. The calibration curves of the nomograms showed good consistency between nomogram prediction and actual survival for both OS and CSS, and the DCAs showed great clinical usefulness of the nomograms. The mCSCC patients were classified into low- and high-risk groups based on the scores from the nomograms. In the validation cohort, mCSCC patients with low-risk had much higher OS and CSS than those with high-risk. We constructed nomograms for predicting the OS and CSS of patients with initially diagnosed mCSCC. Our models had satisfactory predictive performance and could be useful in survival prediction for mCSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database

Ding

Zhou

et al. 2023

Medicine

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“…[ 6 ] Despite this high rate of invasion, metastatic lesions in the brain are relatively rare (~1.5%), and only about 45% of these brain metastases are supratentorial. [ 4 , 17 ] Radiographically, brain metastases are classically located at the grey-white matter junction and usually do not involve the periventricular white matter or extend into the corpus callosum. Gliomas, on the other hand, are usually in the subcortical white matter and involvement of the corpus callosum is frequent.…”

Section: Introductionmentioning

confidence: 99%

Metastatic cervical carcinoma to the brain masquerading as a butterfly glioma: A case report

Kimata,

Abdulrazeq,

Kritselis

et al. 2023

Surgical Neurology International

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Background: Metastatic cervical cancer to the brain is a rare occurrence, representing approximately 1.5% of metastatic cases. We report a rare presentation of cervical cancer with brain metastasis to the corpus callosum. The patient was initially suspected to have a primary glioma but was diagnosed with a metastatic cervical carcinoma lesion through both stereotactic and then opens biopsy. Case Description: A 53-year-old female, with Stage III adenosquamous cervical carcinoma, presented with a large heterogeneously enhancing mass in the corpus callosum body with extension in the cingulate gyrus concerning for glioma. A stereotactic biopsy revealed hypercellular and gliotic brain tissue, while an open biopsy showed an epithelioid neoplasm consistent with metastatic cervical adenosquamous carcinoma. The patient underwent a craniotomy and recovered well and was discharged in stable condition. Conclusion: Brain metastases from cervical cancer are uncommon. We present a rare case of metastatic cervical carcinoma which appeared on imaging to mimic a butterfly glioma. The patient’s history and histopathological examination were essential in determining the correct diagnosis and receiving timely treatment.

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Answer to the Letter to the Editor of Yu Toda, et al. concerning “Incidence and risk factors associated with the development of metastatic spinal cord compression due to bone metastasis in women with cervical cancer” by A. G. Giglio, et al. (Eur Spine J [2022]: doi: 10.1007/s00586-022-07314-8)

et al. 2023

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Prognostic factors for brain metastasis in women presenting cervical cancer

Cited by 3 publications

References 19 publications

Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database

Prognostic models for predicting overall and cancer-specific survival of patients with initially diagnosed metastatic cervical squamous cell carcinoma: A study based on SEER database

Metastatic cervical carcinoma to the brain masquerading as a butterfly glioma: A case report

Answer to the Letter to the Editor of Yu Toda, et al. concerning “Incidence and risk factors associated with the development of metastatic spinal cord compression due to bone metastasis in women with cervical cancer” by A. G. Giglio, et al. (Eur Spine J [2022]: doi: 10.1007/s00586-022-07314-8)

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