Prognostic factors for cutaneous malignant melanoma in Vaud, Switzerland

Levi, Fabio; Randimbison, Lalao; Vecchia, Carlo La; Te, Van‐Cong; Franceschi, Silvia

doi:10.1002/(sici)1097-0215(19981029)78:3<315::aid-ijc10>3.0.co;2-5

Cited by 39 publications

(28 citation statements)

References 31 publications

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“…of metastatic nodes and presence or absence of intralymphatic metastases (in transit or satellite) Note: N1-3 and a-c subcategories assigned as shown below: J AM ACAD DERMATOL VOLUME 65, NUMBER 5 the lesion must be included. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] The clinical information in the pathology report should contain the type of surgical procedure performed (ie, biopsy intenteexcisional or incisional) and size of the lesion. Additional optional, but desirable, clinical information include ABCDE criteria, dermatoscopic features, a clinical photograph, and the presence or absence of macroscopic satellitosis.…”

Section: Nxmentioning

confidence: 99%

Guidelines of care for the management of primary cutaneous melanoma

Bichakjian

Halpern

Johnson

et al. 2011

Journal of the American Academy of Dermatology

416

269

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Section: Nxmentioning

confidence: 99%

Guidelines of care for the management of primary cutaneous melanoma

Bichakjian

Halpern

Johnson

et al. 2011

Journal of the American Academy of Dermatology

416

269

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“…Thickness of melanomas is recorded as the depth in millimeters of the lesion, and we categorized the thicknesses in the same groups as found in Levi et al (1998), for comparative purposes -these thickness groupings (<0.75mm, 0.75-1 .49mm, 1.50-2.49mm, 2.50-3.99mm, >3.99mm and unknown) also represent the levels most commonly used to describe the changing incidence of melanoma, as they are considered representative of the severity of disease: those <0.75mm rarely recur after removal, those 0.75-1.49mm have a greater chance of recurrence but a small chance of mortality, and those >3.99mm have an almost universal prognosis of multiple recurrence and short survival time in clinical series. …”

Section: Tumor Thickness Classificationmentioning

confidence: 99%

Laser interstitial thermal therapy followed by minimal-access transsulcal resection for the treatment of large and difficult to access brain tumors

Wright

Chugh

Wright

et al. 2016

FOC

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OBJECTIVE Laser interstitial thermal therapy (LITT), sometimes referred to as “stereotactic laser ablation,” has demonstrated utility in a subset of high-risk surgical patients with difficult to access (DTA) intracranial neoplasms. However, the treatment of tumors larger than 10 cm3 is associated with suboptimal outcomes and morbidity. This may limit the utility of LITT in dealing with precisely those large or deep tumors that are most difficult to treat with conventional approaches. Recently, several groups have reported on minimally invasive transsulcal approaches utilizing tubular retracting systems. However, these approaches have been primarily used for intraventricular or paraventricular lesions, and subtotal resections have been reported for intraparenchymal lesions. Here, the authors describe a combined approach of LITT followed by minimally invasive transsulcal resection for large and DTA tumors. METHODS The authors retrospectively reviewed the results of LITT immediately followed by minimally invasive, transsulcal, transportal resection in 10 consecutive patients with unilateral, DTA malignant tumors > 10 cm3. The patients, 5 males and 5 females, had a median age of 65 years. Eight patients had glioblastoma multiforme (GBM), 1 had a previously treated GBM with radiation necrosis, and 1 had a melanoma brain metastasis. The median tumor volume treated was 38.0 cm3. RESULTS The median tumor volume treated to the yellow thermal dose threshold (TDT) line was 83% (range 76%–92%), the median tumor volume treated to the blue TDT line was 73% (range 60%–87%), and the median extent of resection was 93% (range 84%–100%). Two patients suffered mild postoperative neurological deficits, one transiently. Four patients have died since this analysis and 6 remain alive. Median progression-free survival was 280 days, and median overall survival was 482 days. CONCLUSIONS Laser interstitial thermal therapy followed by minimally invasive transsulcal resection, reported here for the first time, is a novel option for patients with large, DTA, malignant brain neoplasms. There were no unexpected neurological complications in this series, and operative characteristics improved as surgeon experience increased. Further studies are needed to elucidate any differences in survival or quality of life metrics.

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“…Le i e arkadaşlar n n yapt klar çal şmada cinsiyetin sağkal m etkileyen iki önemli faktörden biri olduğunu saptam şlar e erkek cinsiyetin daha k sa yaşam süresine sahip olduğunu saptam şlard r (16). Ayn şekilde alch e arkadaşlar n n 17600 malign melanom hastas n inceledikleri çal şmada da erkek hastalar kad n hastalara k yasla daha az yaşamakta olduklar rapor edilmiştir (17).…”

Section: Discussionunclassified

“…Le i e arkadaşlar n n çal şmas nda en uzun extremite, ikinci gö de e üçüncü başboyun bölgesi olarak saptanm şt r (16). ortes e arkadaşlar n n çal şmas nda en düşük sağkal m baş boyun bölgesine lokalize olanlarda saptanm ş sonra s ras yla gö de e extremiteler olarak s ralanm şt r (18).…”

Section: Discussionunclassified

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Clinicopathological Analysis of Patients with Malign Melanoma

Aydın¹,

Ünal²,

Somali³

et al. 2015

Acta Oncol Tur.

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1 okuz ylül Üni ersitesi T p akültesi ç Hastal klar Ana ilim al , zmir, Türkiye. 2 zmir ozyaka ğitim Ve Araşt rma Hastanesi T bbi Onkoloji ölümü, zmir, Türkiye. 3 okuz ylül Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. 4 zmir Üni ersitesi T p akültesi ç Hastal klar Ana ilim al ,t bbi Onkoloji ilim al , zmir, Türkiye. ÖZET GİRİŞ ve AMAÇ: u çal şmada Malign Melanom tan l hastalar n Klinikopatolojik özelliklerini incelemeyi amaçlad k. YÖNTEM ve GEREÇLER: u çal şmada okuz ylül Üni ersitesi Hastanesi T bbi Onkoloji bölümünde 1991-2011 Y llar aras nda takip edilen malign melanom tan l 166 hasta retrospektif olarak değerlendirilmiştir. BULGULAR: Hastalardan 87'si erkek, 79'u kad nd r. Tüm hastalar n ortanca yaş 52 (21-81) dir. n s k extremite bölgesinde malign melanom görülürken daha az s kl kta baş boyun e gö dede gözlenmiştir. Primer tümör bölgesi ile breslow kal nl ğ aras nda istatistiksel bir anlaml l k saptanmam şt r(p=0.109). Ancak breslow kal nl ğ ile sağ kal m aras nda istatistiksel bir fark bulunmuştur. reslow kal nl ğ 0-2 mm aras nda olanlar n ortalama sağkal m 125,6 ay(99-151), 2-4 mm aras nda olanlar n ortalama sağkal m 121,2 ay(92-151), 4 mm ve üstünde olanlar n ortalama sağkal m 89 ay(68-111) olarak saptanm şt r e aradaki fark istatistiksel olarak anlaml saptanm şt r(p=0,012). Tüm hastalar n 1 y ll k sağkal m oran %96, iki y ll k sağkal m oran %92.1 e 5 y ll k sağkal m oran %82.7 saptan rken; ortalama sağkal m süresi 89,74±6,9 ay olarak saptanm şt r. Kad n cinsiyette ortalama sağkal m 108.8 ay, erkeklerde ortalama sağkal m 72.7 ay saptanm ş olup aradaki fark istatistiksel olarak anlaml bulunmuştur(P=0,001). Melanomun primer yerleşim yerine göre sağkal mlar s ras yla baş-boyun yerleşiminde 69.6 ay, gö de 114.1 ay, extremite yerleşiminde 82.0 ay olup aradaki fark istatistiksel olarak anlaml saptanmam şt r(P=0,32). TARTIŞMA ve SONUÇ: Malign melanom en kötü seyirli deri tümörü olup prognozu etkileyen faktörler birden fazlad r. u çal şmada en önemli prognostik faktörler breslow kal nl ğ , primer tümör yerleşim bölgesi e cinsiyet olarak saptanm şt r. Anahtar Kelimeler: Malign melanoma, prognoz. ABSTRACT INTRODUCTION:Our aim in this study is to analyse patients with malign melanoma clinicopathologically. METHODS: In this study, 166 malign melanoma patients that followed by Dokuz Eylul University Hospital Medical Oncology Clinic in years between 1996 and 2011 were evaluated retrospectively. RESULTS: 87 of patients is male, 79 is female. The median age is 52 (21-81). The most common site for malign melanoma is extremity; head, neck and body are less commonly involved. There is no statistically significant difference between primary tumor site and breslow thickness (p=0.109). Breslow thickness and survival are related statistically significant. Average survival time for Breslow thickness between 0 and 2mm is 125,6 months (99-151), 2 and 4 mm is 121,2 months (92-151) and over 4mm is 89 months (68-111) and difference between groups are statistically significant (p=0,012)...

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Prognostic factors for cutaneous malignant melanoma in Vaud, Switzerland

Cited by 39 publications

References 31 publications

Guidelines of care for the management of primary cutaneous melanoma

Guidelines of care for the management of primary cutaneous melanoma

Laser interstitial thermal therapy followed by minimal-access transsulcal resection for the treatment of large and difficult to access brain tumors

Clinicopathological Analysis of Patients with Malign Melanoma

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