Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012)

Nie, Zhigang; Lü, Qiang; Peng, Hao

doi:10.1016/j.jbo.2018.09.003

Cited by 25 publications

(23 citation statements)

References 19 publications

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“…At present, the role of sex in CS is still controversial. Some previous studies showed that sex was an independent risk factor, while another several studies revealed that sex was not a prognostic factor . In this study, the ratio of male to female patients was ~1.6:1, which was consistent with such ratios in previous studies .…”

Section: Discussionsupporting

confidence: 91%

“…Some previous studies showed that sex was an independent risk factor, while another several studies revealed that sex was not a prognostic factor. [21][22][23][24] In this study, the ratio of male to female patients was ~1.6:1, which was consistent with such ratios in previous studies. 23,25 Being female was associated with a better prognosis; thus sex was an independent prognostic factor with obvious effects on OS of patients with pelvic CS.…”

Section: Discussionsupporting

confidence: 91%

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Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

et al. 2019

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Background The pelvis is the most common site of chondrosarcoma (CS), and the prognosis for patients with pelvic CS is worse than that for patients with CS in the extremities. However, clinicians have had few tools for estimating the likelihood of survival in patients with pelvic CS. Our aim was to develop nomograms to predict survival of patients with pelvic CS. Methods Data from the Surveillance, Epidemiology, and End Results (SEER) database of patients with pelvic CS between 2004 and 2016 were retrieved for retrospective analysis. Univariate and multivariate Cox analyses were used to identify independent prognostic factors. On the basis of the results of the multivariate analyses, nomograms were constructed to predict the likelihood of 3‐ and 5‐year overall survival (OS) and cancer‐specific survival (CSS) of patients with pelvic CS. The concordance index (C‐index) and calibration curves were used to test the models. Results In univariate and multivariate analyses of OS, sex, pathologic grade, tumor size, tumor stage, and surgery were identified as the independent risk factors. In univariate and multivariate analyses of CSS, pathologic grade, tumor size, tumor stage, and surgery were identified as the independent risk factors. These characteristics except surgery were integrated in the nomograms for predicting 3‐ and 5‐year OS and CSS, and the C‐indexes were 0.758 and 0.786, respectively. Conclusion The nomograms precisely and individually predict OS and CSS of patients with pelvic CS and could aid in personalized prognostic evaluation and individualized clinical decision‐making.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

et al. 2019

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“…Older patient age has been associated with poor survival in chondrosarcoma when analyzing large national registries, 17,18 and was the only analyzed factor found to impact survival and disease recurrence in the current study. Although there was no difference in the age of patients in the current series with grade I or II tumors, increasing patient age was associated with increased death due to disease in both patient groups.…”

Section: Discussionmentioning

confidence: 59%

Advancing patient age is associated with worse outcomes in low‐ and intermediate‐grade primary chondrosarcoma of the pelvis

Houdek

Witten

Hevesi

et al. 2020

Journal of Surgical Oncology

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Background Conventional primary pelvic chondrosarcoma often presents as a low‐ or intermediate‐grade tumor in older patients. Although this is the most common variant of pelvic chondrosarcoma, studies examining treatment outcomes are lacking. The purpose of this study was to evaluate patients with these tumors to determine their outcomes of treatment. Methods Seventy‐three patients (grade I [n = 19, 26%] and grade II [n = 54, 74%]) were reviewed including 55 (75%) males and 18 (25%) females, with a mean age of 51 (range, 17‐81) years and follow‐up of 9 ± 5 years. Results The 10‐year disease‐specific survival was 71%. Grade II disease (hazard ratio [HR], 6.74; P = .04) and age ≥50 years (HR, 3.97; P = .02) was associated with death due to disease. The 10‐year local recurrence‐ and metastatic‐free survival were 79% and 72%. Of the patients with a local recurrence (n = 11), 7 (64%) recurred at a higher histological grade. Patient age ≥50 years was associated with local recurrence (HR, 10.03; P = .02) and metastatic disease (HR, 4.20; P = .02). Conclusion Advancing patient age was an independent risk factor for worse survival and disease recurrence. Tumors often recurred locally at a higher grade and as such wide local excision remains the treatment of choice for these tumors.

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“…17 Three thousand seven hundred thirty seven patients of chondrosarcoma analyzed, showing overall survival rate of 73.9% in five years and patient with distant stage, undifferentiated grade, single radiation have only 30% 5 year survival. 18 A series of 64 patients of localized chondrosarcoma. Thirteen patients had a hemipelvectomy to achieve local tumor control, whereas fifty-one patients underwent a limb-salvage procedure.…”

Section: Seven Patients Withmentioning

confidence: 99%

Chondrosarcoma pelvis, beyond the boundaries.

Sahito

Ali

Kumar

et al. 2020

TPMJ

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Objectives: The objective of our study to find the outcome of extensive chondrosarcoma pelvis after surgery. Study Design: Case Series study. Setting: Department of Orthopaedic Surgery Dow University of Health Sciences / Civil Hospital Karachi. Period: From April 2014 to December 2018. Material & Methods: Seven patients with Chondrosarcoma pelvis included in this study. Results: All Seven patients were male. 2 patient age was in 20’s, three in 40’s and two in 60’s with median age of 44. Clinically presentation of patients was variable. One patient present with groin lump, one with pain and swelling lower abdomen, three with hip pain, one patient with severe gluteal pain and lump, one with massive lump extending from the mid abdomen to groin and urine retention and constipation. Five patients have left pelvis involved and two have right side. Two patients have pubic bone and ischium (Level III) involved, two have ilium (Level I) and three have ilium, acetabulum and pubis (Level I, II, III). Two patients with have preoperatively sciatic nerve palsy. Two patients have medical comorbid. One was asthmatic and one had psychiatric illness. No patient had metastasis at presentation. Pubis and ischium with tumor resected in two cases, partial ilium resection in one case, one complete P1 resection with sciatic nerve, one patient have internal hemipelvectomy and one patient had internal hemipelvectomy that bone recycled in liquid nitrogen and pelvis re-implanted and fixed with recon plates and hip joint reconstructed with total hip replacement. One patient had external hemipelvectomy due to pus at tumor site. Total duration of surgery in patient having thirteen hours, and remaining have 3 to 5 hours. Blood loss during these surgeries was in between 1000 to 1200 ml. Three patients have wound infection, one patient had L5 nerve root injury. Patient with external hemipelvectomy develop wound dehiscence and uro-cutaneous fistula. Two patients died, one with recycled bone after 15 months due cardiac problem and 2nd due to disease related complications within 3 months of surgery. Conclusion: Pelvic chondrosarcoma must be operated by the team of surgeons including orthopaedic surgeon, urologist and general surgeon because of the tumor presents with massive lumps due to unrestricted compartment and can involve the important pelvic organ. With team any complication can be prevented and treated immediately.

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Prognostic factors for patients with chondrosarcoma: A survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973–2012)

Abstract: HighlightsFirst, it is a population-based study which can provide big sample size.Second, similar articles about chondrosarcoma using big data are lacking.Third, the relationship between treatment type and survival outcomes was analyzed in detail.

Cited by 25 publications

References 19 publications

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

Prognostic nomograms to predict overall survival and cancer‐specific survival in patients with pelvic chondrosarcoma

Advancing patient age is associated with worse outcomes in low‐ and intermediate‐grade primary chondrosarcoma of the pelvis

Chondrosarcoma pelvis, beyond the boundaries.

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