Prognostic Factors for Recurrence after Tegafur-uracil Plus Leucovorin Adjuvant Chemotherapy in Patients with Colorectal Cancer

Abstract

: To evaluate prognostic factors for recurrence after tegafur-uracil plus leucovorin UFT / LV adjuvant chemotherapy in patients with colorectal cancer CRC . Consecutive patients with CRC who received UFT / LV as adjuvant chemotherapy at Showa University Hospital between June 2005 and December 2008 were included in the study, 5-year disease-free survival DFS and overall survival OS rates were estimated, and prognostic factors for recurrence were analyzed using the Cox proportional hazards model for multivariate analysis. Of 92 patients included in the study, 17 18.5 had disease recurrence. The 5-year DFS and OS rates were 82.2 and 91.9 , respectively. In the multivariate analysis, preoperative CA19-9 level 37 U / ml, emergency operation, and T4 lesions were independent signi cant prognostic factors after treatment with UFT / LV adjuvant chemotherapy. The three independent prognostic factors T4 lesions, emergency operation, and high preoperative CA19-9 levels may be useful for decision-making regarding whether patients should receive 5-fluouracil-based or L-oxaliplatin-based adjuvant chemotherapy. As this was a single-institution study with a small number of patients, our ndings need to be con rmed in larger multicenter studies..