Prognostic factors for the recurrence of myxoid liposarcoma: 20 cases with up to 8 years follow-up

Lemeur, M.; Mattei, Jean Camille; Souteyrand, P.; Chagnaud, Christophe; Curvale, G.; Rochwerger, Alexandre

doi:10.1016/j.otsr.2014.09.024

Cited by 42 publications

(32 citation statements)

References 31 publications

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“…Even if diagnosis might be considered sooner due to easier palpation detection by patients, this could not explain such a delay. A potential explanation should be a statistical histological subtype preponderance of clear cell, epithelioid, and synovial sarcomas, which may affect younger patients with a lower incidence in DESTS sarcomas of myxoid liposarcomas and liposarcomas, usually developing in older patients . Histological preponderance might also explain DESTS male patient preponderance and impact on prognosis compared to women .…”

Section: Discussionmentioning

confidence: 99%

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

Mattei

Brouste

Terrier

et al. 2019

Journal of Surgical Oncology

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Background and Objectives Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS). Methods From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Demographics, tumor type, treatment modalities, and latest follow‐up status were collected. Primary endpoints were overall survival and local/metastatic recurrence incidences. Results Two hundred five DESTS and 3001 OLSTS were included. The patients were younger, with more female and smaller tumors in DESTS. There were more clear cell/epithelioid sarcomas, synovial sarcomas, and myxoid liposarcomas vs more dedifferentiated liposarcomas in OLSTS. DESTS tumors were less irradiated and more often amputated (24.3% vs 3.4%). The five‐year survival rate was 78.2% compared to 68.6% in OLSTS and after multivariate analysis, STS localization did not impact survival or local/metastatic recurrence. Conclusion Though rare and smaller than other limb localizations, DESTS are to be considered as aggressive. Despite a higher amputation rate, the prognosis remains the same as in OLSTS. Limb sparing vs amputation should be carefully assessed in DESTS, especially if grade 3 or of a poor prognosis histological subtype.

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Section: Discussionmentioning

confidence: 99%

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

Mattei

Brouste

Terrier

et al. 2019

Journal of Surgical Oncology

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“…A study including 20 cases of myxoidliposarcoma, found that after a follow up of 8 years, tumors with more than 5 % of round cells had a greater risk of recurrence [26]. Other authors found the same results [27].…”

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confidence: 72%

Myxoid Liposarcoma With Rare Entity Breast, Thigh and Pelvis: Case Report.

Majnoni¹,

Saedi²,

Esheba³

et al. 2017

IJAR

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“…MLS primarily metastasizes to extrapulmonary sites including bones such as spines and other soft tissues such as retroperitoneum, in contrast to the other subtypes of LP which mainly metastasize to the lung . The percentage of MLS metastasis ranges from 14% to 32%, and its prognostic factors have been previously reported. Factors strongly associated with a poor prognosis include age (>45 years), tumor size (>10 cm), high histological grade, and percentage of round cell differentiation (>5%) .…”

Section: Discussionmentioning

confidence: 96%

“…Factors strongly associated with a poor prognosis include age (>45 years), tumor size (>10 cm), high histological grade, and percentage of round cell differentiation (>5%) . The occurrence of a round cell component is the most significant factor for local recurrence, metastasis, and survival . The risk of local recurrence is 3.4 times greater if a tumor consists of more than 5% round cells.…”

Section: Discussionmentioning

confidence: 99%

“…8 The occurrence of a round cell component is the most significant factor for local recurrence, metastasis, and survival. 7 The risk of local recurrence is 3.4 times greater if a tumor consists of more than 5% round cells. Also, patients with <5% round cells are at a greater risk of poor prognosis compared to pure MLS, 0% round cell population.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent massive myxoid liposarcoma in retroperitoneum 10 years post initial operation

Horiuchi¹,

Maekawa

Obara

et al. 2019

IJU Case Reports

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Introduction Myxoid liposarcoma tends to be a relatively good prognosis. Follow‐up is recommended once a year from the 5th year after surgery. Case presentation A 48‐year‐old man had a massive retroperitoneal tumor, measuring approximately 20 cm. Resection of a huge myxoid liposarcoma had been performed on his back 10 years ago and the weight of the mass was 14 kg. The tumor was resected from the right kidney and its weight was 3.6 kg. Pathological examination showed myxoid liposarcoma and therefore, the tumor was diagnosed as recurrent. But after the resection, no recurrence or metastasis was observed. Conclusion To our knowledge, the case presents the first report where both initial and recurrent tumors were massive and the time for recurrence was 10 years. Therefore, a follow‐up of myxoid liposarcoma might have to be done cautiously throughout the patient's life.

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Prognostic factors for the recurrence of myxoid liposarcoma: 20 cases with up to 8 years follow-up

Abstract: Prognostic factors for the recurrence of myxoid liposarcomas have been identified. MRI analysis is not definitive and must be supplemented by a biopsy.

Cited by 42 publications

References 31 publications

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

Myxoid Liposarcoma With Rare Entity Breast, Thigh and Pelvis: Case Report.

Recurrent massive myxoid liposarcoma in retroperitoneum 10 years post initial operation

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