Prognostic factors for the vascular components of erectile dysfunction in patients on renal replacement therapy

Abstract

A total of 76 male patients on renal replacement therapy (RRT) were investigated. Erectile dysfunction (ED) was defined as insufficient erection during visual erotic stimulation (VES) or during sleep as measured with Rigiscan s and Erectiometer s . Data on medical history, physical examination, and laboratory variables were collected. Furthermore, penile pharmacological duplex ultrasonography (PPDU) was performed. Univariate and multivariate logistic regressions were used to determine prognostic values and to develop prognostic models. Independent prognostic factors for ED were the number of cardiovascular events, waist-hip ratio, body mass index, and acceleration time (AT) as measured with PPDU. Independent prognostic factors for an abnormal AT (4100 ms) were number of cardiovascular events, age category, and the presence of carotid bruits. Independent prognostic factors for insufficient veno-occlusion during PPDU were number of cardiovascular events and supine diastolic blood pressure. The vascular contribution to ED in patients on RRT is substantial. Data from medical history, limited physical examination, and PPDU contribute to the prediction of the vascular contribution to ED.

Erectile Dysfunction in Chronic Hemodialysis Patients in Dakar: a Cross-Sectional Study in 2012

“…Thus, according to many writers, these pathologies are involved in the development of ED ( 7 , 20 , 25 ). Chronic liver disease related to hepatitis virus B or C and heart failure, which are described as potentiating factors of sexual dysfunction in patients on dialysis ( 9 , 19 , 20 ), were objectified in one-third of our patients with 95.5% of them presenting ED. Several widely prescribed therapeutic classes, including β -blockers and diuretics, have been implicated in the onset of ED in patients on dialysis ( 16 , 20 , 21 ).…”

“…These results are similar to previous data reported by Seck et al and Nassir et al who found respectively prevalence of 81.4% in Senegal ( 5 ) and 83% in Saudi Arabia ( 6 ). Lower prevalence of ED has been reported in patients on dialysis living in Spain ( 7 ), Brazil ( 8 ), and Netherlands ( 9 ) (respectively 60%, 54.9%, and 69%). CIGOP in 1981 showed that more than 50% of male patients with CKD showed erectile dysfunction ( 10 ) The mild and moderate grades of ED, with a prevalence of respectively 28.8% and 27.4%, were the most represented severities in our patients.…”

Erectile Dysfunction in Chronic Hemodialysis Patients in Dakar: a Cross-Sectional Study in 2012

“…Thus, according to many writers, these pathologies are involved in the development of ED (7,20,25). Chronic liver disease related to hepatitis virus B or C and heart failure, which are described as potentiating factors of sexual dysfunction in patients on dialysis (9,19,20), were objectified in one-third of our patients with 95.5% of them presenting ED. Several widely prescribed therapeutic classes, including β -blockers and diuretics, have been implicated in the onset of ED in patients on dialysis (16,20,21).…”

“…In patients with ED, four grades of severity were defined as follows: mild (score, 17-21); light (score, 12-16); moderate (score, [8][9][10][11]; and severe (score, 5-7)…”