Prognostic factors in FIGO stage IB–IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: results of a multi-center retrospective Korean study

Abstract

Results: Of the 68 patients, 43 had FIGO stage IB1 SCNEC, 15 had stage IB2, and 10 had stage IIA. Seven were treated with radical surgery alone; 11 with neoadjuvant chemotherapy (NACT) followed by radical surgery; 24 with radical surgery followed by adjuvant chemotherapy; and 26 with radical surgery followed by adjuvant radiation or chemoradiation. After a median follow-up of 44 months (range, 6-113 months), the 2-year and 5-year survival rates for all patients were 64.6% and 46.6%, respectively. Univariate and multivariate analysis showed that FIGO stage was predictive of poor prognosis. Patients who received NACT showed poorer prognosis than those who did not receive NACT. Adjuvant chemoradiation did not improve survival compared with adjuvant chemotherapy alone.Conclusions: FIGO stage may act as a surrogate for factors prognostic of survival. Primary radical surgery followed by adjuvant chemotherapy is the preferred treatment modality for patients with early stage SCNEC.

Small Cell Carcinoma of the Uterine Cervix: Clinical Outcome of Concurrent Chemoradiotherapy with a Multidrug Regimen

“…Notably, all five patients with early stage SCCC including two cases with bulky tumors had no pelvic recurrence, a median survival of 47.4 months and an OS rate at five years of 80%. Although limited by the small number of patients included in this analysis, we did show improvement in the overall survival rate over the previously reported five-year survival of 31.6-46.6% for stage I-IIA patients (Chan et al 2003;Lee et al 2008;Cohen et al 2010). In addition, Cohen et al reported that radical hysterectomy was an independent prognostic factor for survival in a multivariate analysis of 188 patients with SCCC (Cohen et al 2010).…”

Ovarian Metastasis and other Ovarian Neoplasms in Women with Cervical Cancer Stage IA-IIA

“…In cases of early-stage, the rates of LVSI, DSI, pelvic lymph node metastasis and parametrial invasion were high as 60%, 46%, 37% and 13%, respectively (Lee et al, 2008). Although, they have no data of ovarian metastasis in this cell type, certainly, the tendency of metastatic characteristic and the rate of ovarian metastasis were higher.…”

“…Neuroendocrine cervical carcinoma is the most aggressive cell type, high potential of metastasis, and poor prognosis (Lee et al, 2008;Cohen et al, 2010;Wang et al, 2012). In cases of early-stage, the rates of LVSI, DSI, pelvic lymph node metastasis and parametrial invasion were high as 60%, 46%, 37% and 13%, respectively (Lee et al, 2008).…”

Large Cell Neuroendocrine Carcinoma of Female Genital Tract: A Clinicopathological Study of Two Cases with Review of Literature

“…Despite the lack of data, most clinicians favor the use of combined chemotherapy and RT because of the strong evidence supporting concurrent chemoradiotherapy in other subtypes of cervical cancer. Adjuvant chemotherapy alone could be considered an option in patients who have undergone radical hysterectomy [11]. The role of surgery for large cell neuroendocrine carcinoma is not well studied.…”