Prognostic factors in Merkel cell carcinoma: Analysis of 240 cases

Tarantola, Tina I.; Vallow, Laura A.; Halyard, Michele Y.; Weenig, Roger H.; Warschaw, Karen E.; Grotz, Travis E.; Jakub, James W.; Roenigk, Randall K.; Brewer, Jerry D.; Weaver, Amy L.; Otley, Clark C.

doi:10.1016/j.jaad.2012.09.036

Cited by 158 publications

(148 citation statements)

References 15 publications

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“…Factors recognized as associated with poor prognosis are size of the tumor and presence of metastases according to the AJCC staging (4,47,55,(64)(65)(66)(67)(68), and immunosuppression (65,69,70). Recently, histological and immunochemistry markers have been described as potentially associated with poor outcome like low tumor infiltrating CD8 + T cells (101) and P53 and P63 expression and gen mutations (54, 68, 74) ( Table 2).…”

Section: Mcpyv Status and MCC Prognosismentioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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The Merkel cell polyomavirus (MCPyV), identified in humans in 2008, is associated with a relatively rare but aggressive neuroendocrine skin cancer, the Merkel cell carcinoma (MCC). MCC incidence is increasing due to the advancing age of the population, the increase in damaging sun exposure and in the number of immunocompromised individuals. MCPyV must be considered as the etiological agent of MCC and thus is the first example of a human oncogenic polyomavirus. MCPyV infection is common, and seroprevalence studies indicate that widespread exposure begins early in life. The majority of adults have anti-MCPyV antibodies and there is a growing body of evidence that healthy human skin harbors resident or transient MCPyV suggesting that MCPyV infection persists throughout life. However, the mode of transmission, the host cells, and the latency characteristics of this virus remain to be elucidated. In addition, it is still not clear whether MCPyV is associated with diseases or lesions other than Merkel cell carcinoma. The etiologic role of MCPyV in MCC opens up opportunities to improve the understanding of this cancer and to potentially improve its treatment.

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Section: Mcpyv Status and MCC Prognosismentioning

confidence: 99%

Human Merkel cell polyomavirus: virological background and clinical implications

Coursaget

Samimi

Nicol

et al. 2013

APMIS

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“…Thus far, six studies reported survival benefit of sentinel node mapping in cN0 MCC patients [20][21][22][23][24][25]. Table 1 summarizes the characteristics of these studies in addition to their main prognostic findings.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Lymphatic mapping and sentinel node biopsy in a patient with upper limb Merkel Cell Carcinoma: a case report and brief review of literature

Kermani¹,

Rezaei²,

Zarifmahmoudi³

et al. 2016

Nucl. Med. Rev.

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Sentinel node mapping is an integral part of regional lymph node staging in many solid tumors and plays an important role in surgical oncology. This technique has been used with excellent results for non-melanoma skin cancers including Merkel Cell Carcinoma (MCC). In the current study, we reported our first MCC patient who underwent successful sentinel node mapping.We also reviewed the available literature regarding the prognostic significance of sentinel node mapping in cN0 MCC patients.

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“…Primary tumor size was categorized as follows: less than 2 cm (T1), between 2 and 5 cm (T2), greater than 5 cm (T3), and tumor with deep invasion of extra dermal structures (T4), in accordance with the 2010 AJCC staging criteria for MCC (Table 1). 20 Primary tumor sites were evaluated in 4 categories: head and neck, trunk, upper extremity, and lower extremity. For this analysis, combined primary site-specific and disease process-specific causes of death were analyzed.…”

Section: Data Sourcesmentioning

confidence: 99%

“…These data are comparable with previously cited literature by Tarantola et al 20 in their retrospective study and suggest possible future refinements to the current AJCC staging criteria for T stage, which currently only includes size (Table 1). 20 Treatment with WLE has been shown to improve disease-free survival, with margins of 1 to 3 cm recommended. [21][22][23] Nonpalpable microscopic nodal involvement occurs in about one third of clinically localized MCC.…”

Section: Commentsmentioning

confidence: 99%