Prognostic features for acral lentiginous melanoma

Cust, Anne E.

doi:10.1111/bjd.16163

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Any histological subtype of melanoma that occurs on the palms, soles, subungual or dorsum of hands and feet is considered acral melanoma 3,8 . The etiology is uncertain, but several factors such as trauma, chronic inflammation, and mechanical stress have been proposed [3][4][5]8 . As it is a pathology with few symptoms in the initial stages, added to the fact that it affects more advanced age groups and the inherent limitation for self-examination in acral regions, it is often detected in more advanced stages 3 .…”

Section: Discussionmentioning

confidence: 99%

Acral subungual lentiginous melanoma: The importance of early diagnosis and treatment

Davanço¹,

Amaro²,

Neto³

et al. 2023

PJDV

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Acral lentiginous melanoma is uncommon, representing about 4-6% of all melanomas that affect the Caucasian population, but it is the most frequent form of melanoma in Asian and African descendants, with a prevalence above 50%. Peak of incidence is around the sixth decade of life and affects both sexes equally. The etiology is uncertain, but it is suspected that local trauma and traumatic stress are part of the possible triggering factors. Onychomycosis, subungual hematoma, and striated melanonychia generated by a nevus in the nail matrix are part of the differential diagnosis.We present the case of a young patient with melanonychia in the first right finger, with recent onset and progressive alteration, both in color and in the width of the melanonychia, whose histopathology confirmed the diagnosis of subungual melanoma in situ. A surgical approach with removal of the nail apparatus and conservation of the distal phalanx has been successful with no relapse after two years.

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Section: Discussionmentioning

confidence: 99%

Acral subungual lentiginous melanoma: The importance of early diagnosis and treatment

Davanço¹,

Amaro²,

Neto³

et al. 2023

PJDV

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“…In addition, the positive benefits of current first‐line treatments are limited on the ALM patients, both typical radiochemotherapy and molecularly targeted therapy 3,6–8 . Therefore, significant efforts have been made to explore other molecular subtypes that might impact patient care, to greatly improve the clinical outcomes of melanoma patients 28,29 . Interestingly, Ozdeslika et al recently identified a light‐independent function for OPN3 in the regulation of the melanogenic pathway in human epidermal melanocytes, by controlling the activity of the main pigmentation receptor, melanocortin 1 receptor (MC1R) 16 .…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 6 , 7 , 8 Therefore, significant efforts have been made to explore other molecular subtypes that might impact patient care, to greatly improve the clinical outcomes of melanoma patients. 28 , 29 Interestingly, Ozdeslika et al recently identified a light‐independent function for OPN3 in the regulation of the melanogenic pathway in human epidermal melanocytes, by controlling the activity of the main pigmentation receptor, melanocortin 1 receptor (MC1R). 16 Our study found that the downregulation of OPN3 induces apoptosis of human epidermal melanocytes by a calcium‐dependent G protein‐coupled signaling and mitochondrial pathway.…”

Section: Discussionmentioning

confidence: 99%

Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis

Zeng

Zhang

Feng

et al. 2021

Immunity Inflam & Disease

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Background OPN3 upregulation associated with metastasis was recently described in two subtypes of lung cancers. And OPN3 identified in light‐independent functions in epidermal melanocytes has already shown promise. However, in malignant melanocytic tissues, the expression and characterization of OPN3 remain uncharacterized. Objectives We investigated the clinico‐histopathologic features in relation to OPN3 expression of acral lentiginous melanoma (ALM), which is a rare cutaneous melanoma subtype and not associated with prior sunlight exposure. Methods In all, 84 samples of junctional melanocytic nevi (JMN, n = 12), primary ALMs (n = 39) and inguinal lymph node metastasis (ILNM, n = 23) from ALMs were evaluated for the immunohistochemical expression of OPN3. OPN3 messenger RNA and protein level were further determined in melanocytic tumors using quantitative real‐time PCR, multiimmunofluorescence and Western blot assays. We also estimated the associations OPN3 expression between clinicopathological features and prognosis. Results ILNMs, in contrast to JMN and ALMs, had higher OPN3 expression scores (p < .001) by immunohistochemistry analysis. High OPN3 score was associated with presence of ulceration, increased Breslow depth and Clark level (p = .025, p = .042, and p = .012, respectively). Furthermore, a remarkable difference (p = .037) of patient overall survival was found when comparing the OPN3 expression of immunohistochemical score between equal to or larger than 100 and below 100 groups. Also, Cox regression models showed that high OPN3 scores were associated with worse melanoma survival. Conclusion High OPN3 expression is significantly associated with ALMs and metastatic phenotype as well as a poor prognosis.

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“…Clinical subtypes of melanoma have differences in pathogenesis and genetic background; however, ALM as a biologically aggressive subtype remains debatable . Ultraviolet radiation does not play a role in ALM pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Acral lentiginous melanoma: a single‐centre retrospective review of four decades in East‐Central Europe

Csányi

Houshmand

Szűcs

et al. 2020

Acad Dermatol Venereol

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Background Acral lentiginous melanoma (ALM) occurs on the palms, soles and subungual surface and has poor prognosis. It is uncommon in the Caucasian population and has remained unreported in East‐Central Europe. Objectives Our aim was to collect data from East‐Central Europe by analysing the demographic and clinicopathologic features of patients with ALM and comparing data with the reports in literature. Methods We conducted a single‐centre, retrospective review between 1976 and 2016 at one of the largest melanoma referral centres in Hungary. Results We identified 176 patients with ALM (3.83%) from 4593 patients with melanoma (mean age: 66.2 years). The tumours were mainly located on the lower extremities (88.63%). The mean Breslow tumour thickness was 3.861 mm, 37.50% of the tumours were thicker than 4.00 mm, and 71.6% exhibited microscopic ulceration. Nearly one‐third of the patients underwent sentinel lymph node (SLN) biopsy, and 60.3% of the biopsies were positive for metastasis. The positive SLN status was associated with significantly thick tumours and reduced survival. Patients with ALM had 5‐ and 10‐year overall survival rates of 60.5% and 41.6%, respectively. The mean delay in diagnosis was 18 months after the discovery of skin tumours. In multivariate analyses, age, tumour thickness and distant metastasis were independent risk factors for poor survival (P < 0.001). Conclusions Our study, which is the first single‐centre report in East‐Central Europe focusing on ALM, confirms that patient and tumour characteristics and prognostic factors are similar with previous literature data involving Caucasians; however, tumour thickness and survival suggest even worse prognosis.

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Prognostic features for acral lentiginous melanoma

Abstract: Linked Article: Teramoto et al. Br J Dermatol 2018; 178:443–451.

Cited by 7 publications

References 9 publications

Acral subungual lentiginous melanoma: The importance of early diagnosis and treatment

Acral subungual lentiginous melanoma: The importance of early diagnosis and treatment

Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis

Acral lentiginous melanoma: a single‐centre retrospective review of four decades in East‐Central Europe

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