Prognostic Importance of Single-Nucleotide Polymorphisms in IL-6, IL-10, TGF-β1, IFN-γ, and TNF-α Genes in Chronic Phase Chronic Myeloid Leukemia

Pehlıvan, Mustafa; Şahin, Handan Haydaroğlu; Pehlıvan, Sacide; Özdilli, Kürşat; Kaynar, Leylagül; Oğuz, Fatma; Sever, Tuğçe; Yılmaz, Mehmet; Eser, Bülent; Öğret, Yeliz; Kis, Cem; Okan, Vahap; Çetin, Mustafa; Çarin, Mahmut

doi:10.1089/gtmb.2014.0011

Cited by 16 publications

(21 citation statements)

References 38 publications

(39 reference statements)

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“…Furthermore, we observed no differences regarding the frequency of IL‐6 rs1800795 genotypes or alleles among AML patients and controls, our data being similar to the results reported by Nursal et al In contrast, the presence of the rs1800795 variant genotype could be associated with CML susceptibility in Turkish patients …”

Section: Discussionsupporting

confidence: 90%

“…Regarding TGF‐β1 rs1800470, our findings were similar to those of a study performed in Brazil which demonstrated that the TGF‐β1 rs1800470 TT homozygous genotype was associated with an increased risk of developing hematological malignancies (OR = 4.07; 95% CI: 1.94‐8.52; P = .0002), with a 4‐fold increase in the risk of developing hematological cancers . Pehlivan et al found no significant differences between Turkish patients with Philadelphia positive CML and their controls . Contrary to our observations, no difference was observed in a Turkish population for the TGF‐β1 rs1800470 variant genotype …”

Section: Discussionsupporting

confidence: 87%

“…Considering that no association could be detected between the IL‐10 rs1800896 allele or genotype frequency and CML risk, a recent study indicated that IL‐10 could be a useful survival biomarker in CML …”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Nursal et al showed that variants of TNF‐α 238G>A rs361525, IL‐10 (−1082G>A rs1800896, −819C>T rs1800871, −592C>A rs1800872), and TGF‐β1 (codon 25) genes may have a significant association with AML etiopathogenesis . However, no association was observed between TNF‐α −308G>A, IL‐10 (−592T>G, −819T>C, −1082T>C), IFN‐γ +874T>A and TGF‐β1 (codons 10 and 25) polymorphisms and the risk of CML …”

Section: Introductionmentioning

confidence: 97%

“…The association between the IFN‐γ +874T>A (rs2430561) polymorphism and the risk of chronic myeloid leukemia (CML) or chronic lymphocytic leukemia (CLL) was previously evaluated . A recent meta‐analysis suggested that the IFN‐γ +874T>A polymorphism contributes to CML and CLL susceptibility .…”

Section: Introductionmentioning

confidence: 99%

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Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia

et al. 2019

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Background Cytokines were correlated with survival and disease progression in acute myeloid leukemia (AML). We aimed to evaluate the multivariate effect of TNF‐α rs361525, rs1800750, rs1800629, IL‐10 rs1800896, rs1800872, IL‐6 rs1800795, TGF‐β1 rs1800470, IFN‐γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML. Methods All SNPs were genotyped in 226 adult AML cases and 406 healthy individuals. AML patients were investigated for FLT3 (ITD, D835), DNMT3A (R882), and NPM1 type A mutations. Results Univariate analysis revealed that age above 65 years had a negative influence on survival (P < .001). The presence of the rs1800750 variant genotype (P = .005) or FLT3‐ITD mutation (P = .009) in a cytogenetic high‐risk group (P = .003) negatively influenced OS. A negative association was observed between Eastern Cooperative Oncologic Group Scale status > 2, lactate dehydrogenase (LDH) level, platelet (PLT) count <40 000 cells/mm3, and OS. Multivariate Cox regression analysis showed that the presence of the rs1800750 variant genotype was a risk factor for death (P = .007), and that blast percentage, LDH level (≥600 IU/L), and cytogenetic high‐risk were independent significant predictors for death in AML (P = .04, corrected HR = 1.20; P = .022, corrected HR = 1.24; P = .021, corrected HR = 1.34, respectively). Conclusions Age above 65 years, PLT count, TNF‐α rs1800750 variant genotype, blast percentage, LDH level, and cytogenetic high‐risk may be used as independent risk factors to assess AML mortality.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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