Prognostic importance of standardized uptake value on F‐18 fluorodeoxyglucose‐positron emission tomography in biliary tract carcinoma

Abstract

SUV analysis of FDG-PET was useful to predict the prognosis of biliary carcinoma. This information may assist in the guiding of treatment strategies before postoperative pathological assessment.

Metabolic Characteristics of Advanced Biliary Tract Cancer Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Their Clinical Implications

“…This suggests that the greater the tumor burden, the higher the SUV max value. This finding is consistent with reports that SUV max is significantly related to the pathological stage [19,23].…”

“…However, data are limited about the potential of PET to give the information on the prognosis of BTC. Furukawa et al [19] reported that SUV analysis of FDG PET was one of the useful predictors of overall survival for BTC. However, most of the patients in that study had operable BTC, and PET imaging was performed before surgery.…”

Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma

“…Recent studies have reported that volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) using a threshold-based automatic volume of interest (VOI) were better prognostic predictors for survival in patients with malignant pleural mesothelioma, esophageal, tonsilar carcinoma and advanced head and neck squamous cell carcinomas [12][13][14][15]. Although the SUV of biliary carcinoma has been reported to be a useful prognostic predictor for overall survival [16], there are no published studies dealing with the correlation between volumetric PET parameters and prognosis in gallbladder carcinoma. In this study, we investigated the prognostic value of various volume-based metabolic parameters by 18 F-FDG PET/CT compared with other clinical parameters in gallbladder carcinoma.…”

Primary Tumor Maximum Standardized Uptake Value Measured on18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Is a Prognostic Value for Survival in Bile Duct and Gallbladder Cancer

“…12,22,23,25 In bile duct cancer, one study reported a significant association between high SUVmax and advanced pathologic stage. 14 In this study, the pathologic stage was also independently associated poor overall survival in multivariate analysis. However, in our study, high SUVmax was associated with poor overall survival regardless of advanced stage in multivariate analysis.…”

“…[11][12][13][21][22][23] A similar study evaluated the correlation between FDG uptake and prognosis for patients with bile duct and gallbladder cancer. 14 The results showed that high SUVmax was associated with poor overall survival on univariate analysis but was not independently associated with prognosis on multivariate analysis. Kitamura et al 15 reported that SUVmax on FDG PET is an independent predictor of survival in patients with extrahepatic bile duct cancer on multivariate analysis.…”