Prognostic indicators after cardiac surgery in children and their relationship with the oxidative stress response

Gil-Gómez, Raquel; Blasco‐Alonso, Javier; Martín, R. Castillo; Milano-Manso, Guillermo

doi:10.1016/j.redare.2015.07.001

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…The longer the ACC and CPB time, the higher the risk of oxidative stress and related complications. [25] In our study, we found a negative correlation between post-CPB24 native thiol and total thiol levels versus ACC and CPB time (r=-0.438 and r=-0.459; r=-0.461, and r=-0.469, respectively, p<0.01).…”

Section: Table 5 Correlation Analysis Between Post-cpb24 Thiol/disulf...supporting

confidence: 49%

Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery

Tanyildiz,

Filiz Yetimakman,

Uysal Yazici

et al. 2023

Turk Gogus Kalp Dama

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Background: This study aims to investigate whether thiol/disulfide homeostasis parameters measurements could be used as a new biomarker to predict the pre- and post-cardiopulmonary bypass oxidative status of pediatric patients undergoing congenital heart surgery. Methods: A total of 40 children with congenital heart disease (17 males, 23 females; mean age: 39.6±40.0 months; range, 2 to 216 months) who underwent open-heart surgery were included. The control group consisted of 40 age- and sex-matched healthy children (18 males, 22 females; mean age: 42.8±46.6 months; range, 12 to 156 months). The patients with congenital heart disease were divided into two groups as cyanotic patients (n=18) and acyanotic patients (n=22). Thiol/disulfide parameters were compared among the cyanotic, acyanotic congenital heart disease patients, and control group preoperatively (pre-CPB). The effects of cardiopulmonary bypass on thiol/disulfide parameters, pre-CBP, immediately after cardiopulmonary bypass (post-CPB0), and 24 h after cardiopulmonary bypass (post-CPB24) were investigated. Results: The mean native and total thiol levels in the cyanotic patients were significantly lower than those in the acyanotic patients and control group (p<0.0001). The cyanotic group exhibited higher disulfide levels than the acyanotic group (p<0.01). The mean native thiol and total thiol levels significantly decreased in the post-CPB0 (p<0.0001). The mean disulfide levels significantly increased in the post-CPB0 than the pre-CPB values (p<0.001). Post-CPB24 native and total thiol levels were elevated compared to post-CPB0 (p<0.0001). The mean disulfide levels significantly increased in the post-CPB24 period than the post-CPB0 values (p<0.001). The survivor patients responded better to oxidative stress than non-survivor patients. Conclusion: Thiol/disulfide measurement is a promising biomarker in determining the pre- and post-cardiopulmonary bypass oxidative status of pediatric patients undergoing congenital heart surgery. The interpretation of thiol/disulfide levels, pre- and postoperatively, may be used in predicting mortality and outcomes of these patients earlier.

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Section: Table 5 Correlation Analysis Between Post-cpb24 Thiol/disulf...supporting

confidence: 49%

Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery

Tanyildiz,

Filiz Yetimakman,

Uysal Yazici

et al. 2023

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

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Neopterin levels and systemic inflammatory response syndrome in pediatric critically ill patients

Gil-Gómez

Blasco‐Alonso

Sánchez-Yáñez

et al. 2017

Anales de Pediatría (English Edition)

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Oxidative Stress after Surgery on the Immature Heart

Fudulu

Angelini

2016

Oxidative Medicine and Cellular Longevity

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Paediatric heart surgery is associated with increased inflammation and the production of reactive oxygen species. Use of the extracorporeal cardiopulmonary bypass during correction of congenital heart defects generates reactive oxygen species by various mechanisms: haemolysis, neutrophil activation, ischaemia reperfusion injury, reoxygenation injury, or depletion of the endogenous antioxidants. The immature myocardium is more vulnerable to reactive oxygen species because of developmental differences compared to the adult heart but also because of associated congenital heart diseases that can deplete its antioxidant reserve. Oxidative stress can be manipulated by various interventions: exogenous antioxidants, use of steroids, cardioplegia, blood prime strategies, or miniaturisation of the cardiopulmonary bypass circuit. However, it is unclear if modulation of the redox pathways can alter clinical outcomes. Further studies powered to look at clinical outcomes are needed to define the role of oxidative stress in paediatric patients.

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Prognostic indicators after cardiac surgery in children and their relationship with the oxidative stress response

Cited by 5 publications

References 22 publications

Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery

Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery

Neopterin levels and systemic inflammatory response syndrome in pediatric critically ill patients

Oxidative Stress after Surgery on the Immature Heart

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