Prognostic Involvement of Lymph Node Density in Oral Squamous Cell Carcinoma. A New Predictive Model

Verde, Laura; Capote, Ana; Sanz-García, Áncor; Brabyn, Philip; Rodríguez-Campo, F.J.; Gı́as, Luis Naval

doi:10.1016/j.joms.2022.11.012

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The ratio of metastatic LNs was another factor considering both the positive and total examined LNs. It was reflected by two aspects: the surgeon's ability to clean up LNs and the pathologist's ability to detect LNs [14]. Some researchers would like to comment that the ratio was superior to the number in prognosis prediction.…”

Section: Plos Onementioning

confidence: 99%

Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer

Fang,

Dai,

Zhang

et al. 2023

PLoS ONE

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This study aimed to assess the impact of the number and ratio of metastatic lymph nodes (LNs) on prognosis in submandibular gland cancer. To this end, patients were selected from the Surveillance, Epidemiology, and End Results database retrospectively. The effect of the number and ratio of metastatic LNs and the American Joint Committee on Cancer (AJCC) N stage on disease-specific survival (DSS) and overall survival (OS) was analyzed. In addition, prognostic models based on LN evaluation methods were developed to predict the OS and DSS. A total of 914 patients were included. Binary recursive partitioning analysis determined the optimal cut-off number of metastatic LNs (0 vs. 1–2. vs. 3+). The presence of 3+ metastatic LNs carried the greatest impact on prognosis, followed by 1–2 positive LNs occurrences. The ratio of metastatic LNs was an independent factor for DSS and OS. The model had a higher likelihood ratio and C-index than those in the Cox model based on the AJCC N stage. Quantitative LN burden and ratio of metastatic LNs provides better survival stratification than the AJCC N stage.

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Section: Plos Onementioning

confidence: 99%

Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer

Fang,

Dai,

Zhang

et al. 2023

PLoS ONE

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Lymph node ratio (LNR) and lymph node yield (LNY) in head and neck cancer: A systematic review and meta-analysis

Iocca,

Copelli,

Campo

et al. 2024

Journal of Cranio-Maxillofacial Surgery

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Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma

Damazo,

Punjabi,

Liu

et al. 2024

Front. Oral. Health

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ObjectivesRecurrence and survival in early T-stage oral tongue squamous cell carcinoma (OTSCC) may be impacted by histopathologic risk factors. This study aims to examine which of these factors predict long-term outcomes of T1 and T2 OTSCC.MethodsA retrospective review of T1 and T2 OTSCC patients treated with surgery at a single tertiary care center was conducted. Multivariate regression and Kaplan-Meier survival plots were used to identify predictors of recurrence and compare disease-free survival respectively.Results100 consecutive patients were studied. Of these, 51 were staged pT1, 49 pT2, 69 pN0, 10 pN1, and 21 pN2. Multivariate regression analysis revealed that >4 nodes was the strongest predictor of overall recurrence [odds ratio 1.68 (1.23–2.28), p = 0.001], while >4 nodes [odds ratio 1.14 (1.09–1.85), p = 0.008] and pT2 [odds ratio 1.15 (1.01–1.30), p = 0.033] were predictors of local recurrence (R2 = 0.112). Five-year disease-free survival was not significantly impacted by any risk factors except for the number of positive nodes—86% for ≤4 nodes vs. 20% for >4 nodes (p < 0.001)—and pathologic T-stage—90% for pT1 vs. 75% for pT2 (p = 0.035) regardless of adjuvant radiation and/or chemotherapy use.ConclusionsPatients who underwent adjuvant radiation and/or chemotherapy had similar survival to those who did not despite having worse overall tumor prognostic factors. Adding adjuvant therapy may equalize some high-risk histopathologic factors. In the highest risk patients—specifically those with pathologic >4 nodes and pT2 staging—adjuvant therapy should be considered.

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Prognostic Involvement of Lymph Node Density in Oral Squamous Cell Carcinoma. A New Predictive Model

Cited by 3 publications

References 41 publications

Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer

Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer

Lymph node ratio (LNR) and lymph node yield (LNY) in head and neck cancer: A systematic review and meta-analysis

Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma

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