Prognostic markers for pediatric septic shock: which ones, when, and how?

Rey, Corsino; Fortenberry, James D.

doi:10.1007/s00134-013-3027-4

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…To date, most studies using serum lactate as an indicator of tissue hypoxia have been conducted among adults. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…discovered that serial blood lactate levels were a better predictor of death because the duration of lactic acidosis was more significant than the initial lactate value. [ 7 8 ] Although several pediatric studies have shown that higher initial serum lactate levels among children with septic shock are associated with a higher mortality rate, other studies have revealed that increased lactate levels were not solely due to cellular hypoxia. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 7 8 ] Although several pediatric studies have shown that higher initial serum lactate levels among children with septic shock are associated with a higher mortality rate, other studies have revealed that increased lactate levels were not solely due to cellular hypoxia. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

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The Roles of Renal Oxygen Saturation in Septic Shock Children

Kusumastuti,

Ontoseno,

Endaryanto

2023

Journal of Emergencies, Trauma, and Shock

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Introduction: Septic shock, the most severe form of sepsis, has high morbidity and mortality rates among children. In patients with septic shock, impaired microcirculatory perfusion is associated with the severity of organ failure and the likelihood of death. Because near-infrared spectroscopy (NIRS) can assess microcirculation status and peripheral tissue oxygenation directly and noninvasively, provides real-time results, and can be performed at the patient’s bedside. This study aimed to determine the prognostic value of renal oxygen saturation (rRSO2) measured by NIRS in septic shock among children. Methods: This prospective observational study enrolled children aged 1 month to 18 years with septic shock who were treated in a pediatric intensive care unit from August 2020 to January 2021. NIRS was used to measure rRSO2 in patients diagnosed with septic shock according to the Third International Consensus Definition of Sepsis and Septic Shock. The baseline rRSO2 value (%) formed a receiver operating characteristic curve and was used to calculate the optimal cutoff value, sensitivity, specificity, and odds ratio (OR). Results: We enrolled 24 patients, 13 nonsurvivors and 11 survivors, whose mean baseline rRSO2 values were 67.27 ± 12.95 versus 48.69 ± 16.17, respectively (P = 0.006). The optimal cutoff value for baseline rRSO2 was <60.5%, with a sensitivity of 76.9%, a specificity of 81.8%, and an area under curve 0.804 (95% confidence interval [CI]: 59.2%–98.1%, P = 0.012; OR = 15; 95 CI: 2.04–111.74). Conclusion: Measured by NIRS, rRSO2 values are a good predictor of mortality among children with septic shock.

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“…To date, most studies using serum lactate as an indicator of tissue hypoxia have been conducted among adults. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%