Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients

Mertens, Laura S.; Claps, Francesco; Mayr, Roman; Boström, Peter J.; Shariat, Shahrokh F.; Zwarthoff, Ellen C.; Boormans, Joost L.; Abas, Cheno; Leenders, Geert J.L.H. van; Götz, Stefanie; Hippe, Katrin; Bertz, Simone; Neuzillet, Y.; Sanders, Joyce; Broeks, Annegien; Peters, Dennis; Heijden, Michiel S. van der; Jewett, Michael A.S.; Stöhr, Robert; Zlotta, Alexandre R.; Eckstein, Markus; Soorojebally, Yanish; Schoot, Deric K. E. van der; Wullich, Bernd; Burger, Maximilian; Otto, Wolfgang; Radvanyi, François; Sirab, Nanour; Pouessel, Damien; Kwast, Theo H. van der; Hartmann, Arndt; Lotan, Yair; Allory, Yves; Zuiverloon, Tahlita C.M.; Rhijn, Bas W.G. van

doi:10.1016/j.urolonc.2021.10.010

Cited by 31 publications

(24 citation statements)

References 30 publications

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“…In addition, because F-ICG avoids unnecessary PLND, liquid biopsy has recently gained attention as a biomarker to inform clinical decision-making in PCa [ 27 ]. Recently, biomarkers have been explored for various urologic cancers, including prostate cancer [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Liquid biopsy is an emerging biomarker for clinical decision making in PCa [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

A Nomogram for Predicting Prostate Cancer with Lymph Node Involvement in Robot-Assisted Radical Prostatectomy Era: A Retrospective Multicenter Cohort Study in Japan (The MSUG94 Group)

et al. 2022

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Background: To create a nomogram for predicting prostate cancer (PCa) with lymph node involvement (LNI) in the robot-assisted radical prostatectomy (RARP) era. Methods: A retrospective multicenter cohort study was conducted on 3195 patients with PCa who underwent RARP at nine institutions in Japan between September 2012 and August 2021. A multivariable logistic regression model was used to identify factors strongly associated with LNI. The Bootstrap-area under the curve (AUC) was calculated to assess the internal validity of the prediction model. Results: A total of 1855 patients were enrolled in this study. Overall, 93 patients (5.0%) had LNI. On multivariable analyses, initial prostate-specific antigen, number of cancer-positive and-negative biopsy cores, biopsy Gleason grade, and clinical T stage were independent predictors of PCa with LNI. The nomogram predicting PCa with LNI has been demonstrated (AUC 84%). Using a nomogram cut-off of 6%, 492 of 1855 patients (26.5%) would avoid unnecessary pelvic lymph node dissection, and PCa with LNI would be missed in two patients (0.1%). The sensitivity, specificity, and negative predictive values associated with a cutoff of 6% were 74%, 80%, and 99.6%, respectively. Conclusions: We developed a clinically applicable nomogram for predicting the probability of patients with PCa with LNI.

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Section: Discussionmentioning

confidence: 99%

A Nomogram for Predicting Prostate Cancer with Lymph Node Involvement in Robot-Assisted Radical Prostatectomy Era: A Retrospective Multicenter Cohort Study in Japan (The MSUG94 Group)

et al. 2022

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“…This finding was observed by a number of researchers. 7,13,15 No significant association was found between Lymphovascular and perineural invasion and Ki-67 expression. The data regarding these variables varied among authors.…”

Section: Discussionmentioning

confidence: 94%

“…Similar results were obtained in other studies as well. 7,13,14,15 Among the other parameters, overexpression of Ki-67 was associated with lymph node metastasis. This finding was observed by a number of researchers.…”

Section: Discussionmentioning

confidence: 99%

Association of Ki-67 expression in radical cystectomy specimens of infiltrating urothelial carcinoma with histopathological parameters

Rahman

Khan

Afroz

et al. 2023

Bangabandhu Sheikh Mujib Medical University Journal

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Urothelial carcinoma is the most common neoplasm of urinary bladder. Antigen Ki-67 is a nuclear protein that is necessary for cellular proliferation. The aim of this study was to determine the association of expression of Ki-67 with histopathological parameters in radical cystectomy specimens of histologically diagnosed cases of infiltrating urothelial carcinoma. This is a cross-sectional study conducted among 36 cases of infiltrating urothelial carcinoma collected from Department of Pathology, Bangabandhu Sheikh Mujib Medical University. Histopathological parameters i.e. morphologic variants, stage (pT), lympho-vascular invasion, perineural invasion and lymph node metastasis were assessed. Ki-67 immunohistochemistry were performed. Mean ±SD age of the patients was 58.9±13.8 years. Among the morphological variants, 64% cases were microscopically arranged in papillary pattern. Eighteen (50%) patients underwent surgical intervention at stage pT2. Lympho-vascular invasion, perineural invasion and lymph node metastasis were identified in 12 (33.3%), 9 (25%) and 13 (48.1%) of the cases, respectively. Among the morphological parameters, Ki-67 shows association with pathological stages and lymph node metastasis. The use of Ki-67 immunomarker along with grading and staging may provide significant prognostic information in urothelial carcinoma of the urinary bladder. BSMMU J 2022; 15(3): 186-191

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“…Along with histological staging, the application of immunohistochemistry in clinical practice is growing. Several molecular markers predict clinical outcomes of the curative treatment and can identify patients who would benefit from additional treatment (conventional or targeted therapies/immunotherapy) [ 46 , 47 ]. Therefore, optimizing patient selection through novel biomarkers and advanced imaging might improve tumor stratification and drive treatment towards personalised strategies [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review

Tian

Tao

et al. 2023

Medicina

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Primary urethral adenocarcinoma in females is an extremely rare malignancy with unclear origin and only a few retrospective cases have been reported. The controversy continues to exist over the origin of primary urethral adenocarcinoma from periurethral glands (which include the Skene’s glands), urethritis glandularis or intestinal metaplasia. Herein, we report one case of a 49-year-old female with distal urethral adenocarcinoma who presented with obstructive voiding. Abdominal and pelvic CT scans and chest radiology were unremarkable. Biopsy of the mass confirmed urethral adenocarcinoma. The patient underwent partial ureterectomy and was disease-free at the 2-years follow-up period. We also present another extremely rare case of primary urethral adenocarcinoma with mucinous features in a 58-year-old female who initially complained of external urethral orifice itching with painless urethral bleeding and was treated with local excision. The patient has not received any neoadjuvant or adjuvant therapy, and experienced tumor recurrence, inguinal lymph nodes metastasis, and even local iliopsoas metastasis during over 10-years follow-up. In conclusion, our current study emphasizes the importance of imaging studies and biopsy in making an accurate preoperative diagnosis of this rare disease, and further highlights the role of multimodal therapy. A combination of radiotherapy, chemotherapy and surgery is recommended for the optimal local and distant disease control. Moreover, better medical compliance and regular follow-up are required in these patients.

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Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients

Cited by 31 publications

References 30 publications

A Nomogram for Predicting Prostate Cancer with Lymph Node Involvement in Robot-Assisted Radical Prostatectomy Era: A Retrospective Multicenter Cohort Study in Japan (The MSUG94 Group)

A Nomogram for Predicting Prostate Cancer with Lymph Node Involvement in Robot-Assisted Radical Prostatectomy Era: A Retrospective Multicenter Cohort Study in Japan (The MSUG94 Group)

Association of Ki-67 expression in radical cystectomy specimens of infiltrating urothelial carcinoma with histopathological parameters

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review

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