Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: A systematic review

Ribeiro, Jean Alex Matos; García-Salazar, Luisa Fernanda; Saade-Pacheco, Cássia Regina; Silva, Érika Shirley Moreira; Oliveira, Simone Garcia; Silveira, Ana Flávia; Araújo, Adriana; Russo, Thiago Luiz

doi:10.1016/j.cca.2021.08.006

Cited by 6 publications

(4 citation statements)

References 87 publications

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“…Generally, stroke diagnosis depends crucially on neuroimaging; computed tomography remains an essential component of stroke management, although it is not always available [ 17 ]. Over the last decades, molecular biomarkers for stroke have gained the attention of clinicians around the world owing to their broad application in facilitating diagnosis, characterizing clinical size and severity, estimating long-term prognoses, and selecting an appropriate treatment option [ 18 , 19 ]. The National Institutes of Health Biomarkers Definitions Working Group proposed a new definition of biomarkers in 2001: “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention” [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Kim

Shin

Chang

2022

IJMS

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Stroke is a primary debilitating disease in adults, occurring in 15 million individuals each year and causing high mortality and disability rates. The latest estimate revealed that stroke is currently the second leading cause of death worldwide. Post-stroke cognitive impairment (PSCI), one of the major complications after stroke, is frequently underdiagnosed. However, stroke has been reported to increase the risk of cognitive impairment by at least five to eight times. In recent decades, peripheral blood molecular biomarkers for stroke have emerged as diagnostic, prognostic, and therapeutic targets. In this study, we aimed to evaluate some blood-derived proteins for stroke, especially related to brain damage and cognitive impairments, by conducting a systematic review and meta-analysis and discussing the possibility of these proteins as biomarkers for PSCI. Articles published before 26 July 2021 were searched in PubMed, Embase, the Web of Science, and the Cochrane Library to identify all relevant studies reporting blood biomarkers in patients with stroke. Among 1820 articles, 40 were finally identified for this study. We meta-analyzed eight peripheral biomarker candidates: homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), uric acid, and glycated hemoglobin (HbA1c). The Hcy, CRP, TC, and LDL-C levels were significantly higher in patients with PSCI than in the non-PSCI group; however, the HDL-C, TG, uric acid, and HbA1c levels were not different between the two groups. Based on our findings, we suggest the Hcy, CRP, TC, and LDL-C as possible biomarkers in patients with post-stroke cognitive impairment. Thus, certain blood proteins could be suggested as effective biomarkers for PSCI.

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Section: Introductionmentioning

confidence: 99%

Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Kim

Shin

Chang

2022

IJMS

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“…Understanding the impact of ART on these ratios is crucial for optimizing patient care. [22] As effective ART often leads to immune recovery, monitoring changes in platelet index ratios can provide insights into the response to treatment. An increasing PLR and normalization of MPV/PC may signify improved immune health.…”

Section: Platelet Index Ratios In Hiv Carementioning

confidence: 99%

Platelet index ratios in HIV: Emerging biomarkers for immune health and disease management

Obeagu,

Obeagu

2024

Medicine

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Human Immunodeficiency Virus (HIV) infection is a global health challenge that requires continuous advancements in diagnostic and prognostic tools. Traditional markers, such as CD4 cell counts and viral load, have played a crucial role in monitoring disease progression and guiding therapeutic interventions. However, emerging research suggests that platelet index ratios may serve as valuable biomarkers in assessing immune health and managing HIV-associated complications. This paper explores the significance of platelet index ratios, including platelet-to-lymphocyte ratio and mean platelet volume-to-lymphocyte ratio, as potential indicators of immune system status in individuals living with HIV. The interplay between platelets, lymphocytes, and their ratios reflects the dynamic nature of the immune response and inflammatory processes during HIV infection. Understanding the role of platelet index ratios in HIV could lead to the development of accessible and cost-effective biomarkers for monitoring immune health. Implementation of these ratios in routine clinical practice may enhance the precision of disease prognosis and guide personalized treatment strategies. Additionally, the exploration of platelet index ratios may pave the way for innovative therapeutic interventions aimed at modulating immune responses in HIV-infected individuals. In conclusion, platelet index ratios represent promising emerging biomarkers for evaluating immune health and managing HIV-related complications. Further research and clinical validation are warranted to establish the utility of these ratios in routine HIV care, potentially revolutionizing the approach to monitoring and improving the health outcomes of individuals living with HIV.

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“…By synergistically amalgamating medical imaging technology and the omnipotent prowess of big data analytics, healthcare professionals have enhanced capabilities to meticulously assess the propensity for hematoma expansion and edema [14]. This newfound understanding catalysis shaping tailored, individualized treatment plans [15], thus was engendering a palpable improvement in patient prognoses.…”

Section: Introductionmentioning

confidence: 99%

“…The harmonious integration of techniques drawn from medical imaging [21] and big data analytics [22] kindles within us the remarkable ability to facilitate the prognosis of patients grappling with hemorrhagic stroke. Armed with accurate diagnostic capabilities and individualized treatment plans [23], we can effectively mitigate the harmful impact of hematoma expansion and edema, elevating life quality and fostering notable functional recovery among afflicted individuals.…”

Section: Introductionmentioning

confidence: 99%

Biomathematical Modeling in Clinical Intelligent Diagnosis and Treatment

2024

OAJDA

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Hemorrhagic stroke, a severe cerebrovascular disorder caused by the rupture of brain blood vessels, is characterized by high acute mortality rates and enduring neurological impairments. To provide more targeted clinical recommendations, this study, based on the clinical data of patients with hemorrhagic stroke, extensively explores the relationships between edema changes, treatment conditions, and modified Rankin Scale (MRS) scores. The HemExPred, EdemaVolReg, and PrognosisPred models are meticulously designed to address these three critical aspects. In this study, we skilfully employed machine learning techniques to identify characteristics associated with hematoma expansion events, with the effectiveness of the ElasticNet technique being particularly notable. Additionally, polynomial regression demonstrated exceptional fitting capabilities in deciphering the complexities of edema volume changes. Utilizing the ExtraTreesRegressor model, with an R^2 of 94.6% and 90.6%, we successfully predicted the future trajectories of patients, affirming that hematoma volume, edema volume, and age are key determinants of prognosis. Through in-depth analysis, this research provides valuable insights for clinical decision-making in hemorrhagic stroke, aiding physicians in devising more precise and effective treatment strategies.

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Prognostic molecular markers for motor recovery in acute hemorrhagic stroke: A systematic review

Cited by 6 publications

References 87 publications

Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

Platelet index ratios in HIV: Emerging biomarkers for immune health and disease management

Biomathematical Modeling in Clinical Intelligent Diagnosis and Treatment

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