Prognostic nomogram for patients with tongue squamous cell carcinoma: A SEER‐based study

Abstract

ObjectivesIn order to predict the patients' prognosis with tongue squamous cell carcinoma (SCC), this study set out to develop a clinically useful and trustworthy prognostic nomogram.Subjects and MethodsThe Surveillance, Epidemiology, and End Results (SEER) Program was used to compile clinical information on patients with tongue SCC between 2010 and 2015. The likelihood of Cancer‐Specific Survival (CSS) and Overall Survival (OS) for specific patients was predicted using a prognostic nomogram created with the help of the RStudio software. The nomogram's predictive ability was evaluated using the consistency index (C‐index) and decision curve analysis, and the nomogram was calibrated for 1‐, 2‐, 3‐, 5‐, and 10‐year CSS and OS.ResultsPatients numbering 6453were enrolled in this study. The primary cohort (3895) and validation cohort (2558) were each randomly assigned. Sex, age, tumor‐node‐metastasis (TNM) stage, surgery, chemotherapy, and radiation were significant risk factors for OS, whereas age, TNM stage, surgery, chemotherapy, and radiotherapy were significant risk factors for CSS. Additionally, C‐index and calibration curves indicated that the prognostic nomogram prediction and the actual observation in both cohorts would be very coherent.ConclusionsThe predictive nomogram created in this study can offer patients with tongue SCC customized treatment and survival risk assessment.

Prognostic factors in surgically treated tongue squamous cell carcinoma in stage T1‐2N0‐1M0: A retrospective analysis

“…The TNM stage is one of the main prognostic factors of TSCC patients after surgery. [22][23][24] In accordance, the present study found that pTNM stage was an independent prognostic factor of OS, DFS, and LRFS. Besides, pT and pN stage also have been reported as independent risk factors of OS and disease-specific survival for patients with oral cancer, 13,25 which is consistent with our finding that stage pT and pN were associated with OS and DFS.…”

“…The TNM stage is one of the main prognostic factors of TSCC patients after surgery 22–24 . In accordance, the present study found that pTNM stage was an independent prognostic factor of OS, DFS, and LRFS.…”