Prognostic nomogram for patients with minor stroke and transient ischaemic attack

Abstract

BackgroundIschaemic stroke and transient ischaemic attack (TIA) share a common cause. We aim to develop and validate a concise prognostic nomogram for patients with minor stroke and TIA.MethodsA total of 994 patients with minor stroke and TIA were included. They were split into a derivation (n=746) and validation (n=248) cohort. The modified Rankin Scale (mRS) scores 3 months after onset were used to assess the prognosis as unfavourable outcome (mRS≥2) or favourable outcome (mRS<2).ResultThe final model included seven independent predictors: gender, age, baseline National Institute of Health Stroke Scale (NIHSS), hypertension, diabetes mellitus, white blood cell and serum uric acid. The Harrell’s concordance index (C-index) of the nomogram for predicting the outcome was 0.775 (95% CI 0.735 to 0.814), which was confirmed by the validation cohort (C-index=0.787 (95% CI 0.722 to 0.853)). The calibration curve showed that the nomogram-based predictions were consistent with actual observation in both derivation cohort and validation cohort.ConclusionThe proposed nomogram showed favourable predictive accuracy for minor stroke and TIA. This has the potential to contribute to clinical decision-making.

Developing and Validating a New Model to Predict the Risk of Poor Neurological Status of Acute Ischemic Stroke After Intravenous Thrombolysis

“…Szlachetka et al 58 developed and validated a nomogram for predicting 10-year ischemic stroke mortality. Lei et al 59 developed and validated a concise prognostic nomogram for patients with minor stroke and TIA.…”

Desenlace funcional asociado al ataque cerebrovascular menor en una población colombiana: un estudio de cohorte

“…En la literatura, factores como la edad avanzada (13)(14)(15)(16)(17), el sexo femenino (13,14,16), la localización anatómica de la lesión (cápsula interna, puente y corona radiada) (18), aspectos de la NIHSS (1,14-16) e ítems específicos de esta escala (13,17,18), la oclusión de gran vaso (5,6,13,14,17,19), entre otros, han sido asociados con desenlaces desfavorables en los pacientes con ACV menor. La asociación de dia-betes y desenlace desfavorable es concordante con estudios previos (14,16,(20)(21)(22) y se ha considerado que incluso los estados prediabéticos (20,22), son un factor de riesgo independiente en la recurrencia de nuevos eventos isquémicos en pacientes con ACV menor o ataque isquémico transitorio. Se cree que el estado hiperglucémico contribuye al desarrollo de rigidez arterial y disfunción endotelial en estos pacientes, lo que puede favorecer el desarrollo de un nuevo ACV, en especial cuando la etiología es por obstrucción de pequeño vaso (20)(21)(22).…”

A nomogram for individualized prediction of lower extremity deep venous thrombosis in stroke patients: A retrospective study

“…Nomogram is a graphical model, in which, certain risk factors may work together to make exact predictions; several nomograms have been taken as the tools for predicting various diseases. [9][10][11] At present, there is still not a DVT prediction model specifically combining hemiplegic limb function and the living ability of stroke patients. Therefore, in this study, we intended to determine the clinical predictors of DVT in cerebral stroke patients based on their limb function and living ability, to develop and validate the nomogram, thus assisting in the clinical prediction of lower extremity DVT.…”