Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

“…14 of the remaining 35 studies (Kim et al, 2006;Murakami et al, 2008;Balentine et al, 2010;Chu et al, 2010;Kanda et al, 2010;de Jong et al, 2011;Jamieson et al, 2011;Kneuertz et al, 2011;Maithel et al, 2011;Singal et al, 2011;Chatterjee et al, 2012;Watanabe et al, 2012;Xie et al, 2012;Fisher et al, 2013) were excluded because they were reported by the same institutions as other studies. 21 studies (Ozaki et al, 1999;Mitsunaga et al, 2005;Nakagohri et al, 2006;Pawlik et al, 2007;Kazanjian et al, 2008;Kato et al, 2009;Nagai et al, 2009;Sergeant et al, 2009;Ben et al, 2010;Murakami et al, 2010;Bachellier et al, 2011;Kim et al, 2011;Schiffman et al, 2011;Cheng et al, 2012;Jamieson et al, 2012;Lee et al, 2012;Murata et al, 2012;Sahin et al, 2012;Takahashi et al, 2012;Turrini et al, 2013;Xie et al, 2013) were included in the final meta-analysis, comprising one case matched controlled study and 20 retrospective cohort studies (Table 1). A total of 4459 patients were included in this meta-analysis.…”

“…Perineural invasion(PNI), which was described as the spread of cancer cells in the perineural spaces of the nerves (Kayahara et al, 2007;Liebig et al, 2009), has been reported as one of the sources of local recurrence in resected pancreatic cancer (Pour et al, 2003). And PNI is regarded as a prominent characteristic of pancreatic cancer, because the incidence of PNI is particularly high in pancreatic cancer among varied cancers (Bapat et al,Jun-Feng Zhang & , Rong Hua*, Yong-Wei Sun, Wei Liu, Yan-Miao Huo, De-Jun Liu & , Jiao Li several studies showed that PNI was not a prognostic parameter (Pawlik et al, 2007;Schiffman et al, 2011;Jamieson et al, 2012;Turrini et al, 2013). A systematic review (Garcea et al, 2008) analysed studies detailing outcomes following resection for PDAC from 1980 to 2008 and showed that meta-analysis of yearly survival data for PNI did not achieve statistical significance.…”

Preoperative volume-based PET parameter MTV2.5 as a potential surrogate marker for tumor biology and recurrence in resected pancreatic cancer

“…Increased tumor size, 12 positive lymph node metastasis, 13 increased lymph node ratio, 14 high tumor grade, 15 positive lymphovascular 16 or perineural invasion, 17 and positive margin-status 18 represent aggressive tumor behaviors in pancreatic cancer that lead to early treatment failure and resistance to conventional chemotherapy. Determining these prognostic factors is a key component of developing an effective and reasonable treatment strategy based on accurate cancer biologic behavior.…”

Metastatic Axillary Lymph Node Ratio (LNR) is Prognostically Superior to pN Staging in Patients with Breast Cancer -- Results for 804 Chinese Patients from a Single Institution

“…Previous studies have demonstrated that the effects of LNR staging is superior to that of pN staging in predicting prognosis of patients for many cancer sites: colon (Chen et al, 2011), gastric (Wang et al, 2011;Yu et al, 2011), pancreas (Pawlik et al, 2007;Keck et al, 2012), esophagus (Greenstein et al, 2008), corpus uteri (Chan et al, 2007) and bladder (Herr, 2003).…”