Prognostic significance of elevated serum β2-microglobulin levels in adult acute lymphocytic leukemia

Kantarjian, Hagop M.; Smith, Terry L.; Estey, Elihu H.; Polyzos, A.; O’Brien, Susan; Pierce, Sherry; Beran, Miloslav; Feldman, Eric J.; Keating, Michael J.

doi:10.1016/0002-9343(92)90191-d

Cited by 38 publications

(17 citation statements)

References 15 publications

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“…A strong correlation was observed between serum HA and β 2 -microglobulin, an accepted prognostic marker in patients with acute leukemia and other hematological malignancies [44,45,46,47,48], supporting the significance of our results of an inverse correlation between the increased serum HA levels and survival. This is in agreement with the findings of Dahl et al [28], but in contrast with the findings of Αbildgaard et al [29], who reports no significant prognostic value of β 2 -microglobulin in serum.…”

Section: Discussionsupporting

confidence: 77%

Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

et al. 2017

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Background: Studies on the serum concentration of hyaluronic acid (HA) in newly diagnosed patients with acute myeloid leukemia (AML), B-acute lymphoblastic leukemia (B-ALL), and mantle-cell lymphoma (MCL) are scarce. In this study, we focused on investigating whether HA could serve as a possible prognostic marker in patients with AML, B-ALL, and MCL. Methods: The serum concentration of HA was measured in a total of 51 patients with newly diagnosed AML, B-ALL, and MCL. Venous blood was collected 1 day before the initiation of chemotherapy (D0), on day 16 of the first cycle of chemotherapy (D16), and on D30. Results: The serum HA concentration on D0 in patients with AML, B-ALL, and MCL was higher than in the control group. For all types of hematological malignancy, on D0, serum HA values of nonsurvivors were higher than in survivors. Moreover, patients in relapse had higher levels of serum HA than patients in remission. A strong positive correlation between serum HA and ferritin, β₂-microglobulin, and lactate dehydrogenase was found. Conclusion: Serum HA may serve as a possible prognostic marker for AML, B-ALL, and MCL patients, especially on D0. Prospective case-control studies on larger populations may provide further information.

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Section: Discussionsupporting

confidence: 77%

Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

et al. 2017

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“…Elevated serum h2M levels are reported to predict poor survival in several hematologic malignancies, which include multiple myeloma (11), low-grade lymphomas (12), large-cell lymphomas (13 -15), Hodgkin's lymphoma (16,17), acute lymphoblastic leukemia (18), Philadelphia chromosome -positive chronic myeloid leukemia (19), chronic lymphocytic leukemia (20,21), and myelodysplastic syndromes (22,23).…”

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confidence: 99%

The Prognostic Significance of Serum β2 Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients

Tsimberidou¹,

Kantarjian²,

Wen

et al. 2008

Clinical Cancer Research

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Purpose: Serum h 2 microglobulin (h2M) is prognostic in other hematologic malignancies; therefore, we evaluated its prognostic significance in acute myeloid leukemia (AML). Experimental Design: Multivariate analyses were used to examine the effect of pretreatment serum h2M levels on clinical outcomes in patients with AML. h2M was associated with poorer survival in older but not younger patients. We thus fit separate Cox survival models in patients above and below age 60 years treated with remission induction therapy containing high-dose cytarabine (n = 1,280). In each age group, 50% of the patients were used to develop the model, which was tested in the other 50%. Resampling methods were also used to validate the independent prognostic significance of covariates. Results: In patients 60 years or older (n = 591), poorer risk cytogenetics; poorer performance status; and higher levels of h2M, uric acid, and lactate dehydrogenase were each found to independently predict shorter survival and formed the basis of a scoring system. A similar approach was used in patients younger than 60 years (n = 589), with poorer risk cytogenetics, poorer performance status, older age, higher hemoglobin level, and higher leukocyte count predicting a shorter survival and forming the basis of the scoring system. Higher h2M levels were an adverse independent factor for response, survival, relapse-free survival, and event-free survival in older but not in younger patients. Conclusions: Serum h2M levels can help predict outcome in patients z60 years with untreated AML, and their use is strongly encouraged.

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“…18 B2M was the only variable predicting the response of high-risk MDS to intensive chemotherapy. 3 The prognostic importance of B2M may be related to its role in the immunological response of the host to the malignancy.…”

Section: Resultsmentioning

confidence: 97%

Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)

Gatto

Ball

Onida

et al. 2003

Blood

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Prospective analysis of the importance of the plasma levels of ␤-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS. (Blood. 2003;102: 1622-1625)

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Prognostic significance of elevated serum β2-microglobulin levels in adult acute lymphocytic leukemia

Cited by 38 publications

References 15 publications

Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

Serum Hyaluronic Acid Levels Are Altered in Acute Leukemia Patients: Potential Prognostic Implications

The Prognostic Significance of Serum β2 Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients

Contribution of β-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)

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