Prognostic significance of lymph node involvement in middle and distal bile duct cancer

Sasaki, Ryoko; Takahashi, Masahiro; Funato, Osamu; Nitta, Hiroyuki; Murakami, Masahiko; Kawamura, Hidenobu; Sakai, Takayuki; Kanno, Senji; Saito, Kazuyoshi

doi:10.1067/msy.2001.114555

Cited by 59 publications

(44 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported that patient's prognosis of the extrahepatic bile duct carcinoma was associated with several clinicopathological features, such as tumor histological type, lymph nodal status, stage, location, vascular/nervous invasion and surgical margin (14,31,43,46). Our study also demonstrated that the histological grade, lymph nodal status, and vascular/nervous invasion were significantly associated with clinical outcome.…”

Section: Discussionsupporting

confidence: 72%

Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma

et al. 2009

View full text Add to dashboard Cite

Extrahepatic bile duct carcinoma is one of the most extremely aggressive cancers with poor prognosis after curative resection. Syndecan-1 and E-cadherin are transmembrane glycoproteins, and have important roles in cell-cell adhesion and tumor progression. In this study, we examined 84 surgically resected cases of extrahepatic bile duct adenocarcinoma to clarify clinicopathological significance of syndecan-1/E-cadherin expression. Reduced expressions of syndecan-1 and Ecadherin were found in 69.0% (58/84) and 46.4% (39/84) of the bile duct carcinomas. Reduced syndecan-1 expression was correlated with lymphatic/venous/nervous invasion (P < 0.0001), and was associated with short overall survival (P = 0.0002). Reduced E-cadherin expression was correlated with lymphatic and nervous invasion (P = 0.008, P < 0.0001, respectively), and was associated with short overall survival (P = 0.0038). The results indicated that reduced syndecan-1/ E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma.

show abstract

Section: Discussionsupporting

confidence: 72%

Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Furthermore, the cell differentiation, the T stage and the TNM stage were significant factors that affected the outcomes. It has been reported that the frequency of LN metastasis in DBD ranged from 30% to 68% [7,8,11,14,20,23] , and negative LN metastasis was a useful predictor of a favorable outcome for patients with DBD [7,8,14,23] . However, perineural invasion did not prove to be statistically significant, unlike the other studies that reported the risk factors for survival from cholangiocarcinoma in other parts of the biliary tree [24,25] .…”

Section: Discussionmentioning

confidence: 99%

“…Although several authors have reported that MBD had a worse prognosis than hilar or distal bile duct cancer [26][27][28] , other authors did not concur [8,29] . According to previous reports, the curative resection rates for DBD have ranged from 56% to 100% [7,8,14,[19][20][21][22] . However, the 5-year survival rate for DBD is not always high, with some reports showing a range of 14%-47% [7,8,11,14,[19][20][21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…According to previous reports, the curative resection rates for DBD have ranged from 56% to 100% [7,8,14,[19][20][21][22] . However, the 5-year survival rate for DBD is not always high, with some reports showing a range of 14%-47% [7,8,11,14,[19][20][21][22][23] . In the present study, the overall 3-year and 5-year survival rates of the BDSR group were 51.7% and 36.6%, respectively, which is similar to other published reports [7,8,11,14,[19][20][21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…There have been occasional reports of BDSR for treating extrahepatic cholangiocarcinoma in selected patients [7,8,[19][20][21][22] . In the series from the Memorial Sloan Kettering Cancer Center [7] , only 13% of patients (6 of 45) were amenable to bile duct excision alone, while this figure was 8% (3 of 34) in the Veterans Hospital study [22] .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Carcinoma of the middle bile duct: Is bile duct segmentalresection appropriate?

Lee¹,

Lee²,

Yoo³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To compare survival between bile duct segmental resection (BDSR) and pancreaticoduodenectomy (PD) for treating distal bile duct cancers. METHODS:Retrospective analysis was conducted for 45 patients in a BDSR group and for 149 patients in a PD group. RESULTS:The T-stage (P < 0.001), lymph node invasion (P = 0.010) and tumor differentiation (P = 0.005) were significant prognostic factors in the BDSR group. The 3-and 5-year overall survival rates for the BDSR group and PD group were 51.7% and 36.6%, respectively and 46.0% and 38.1%, respectively (P = 0.099). The BDSR group and PD group did not show any significant difference in survival when this was adjusted for the TNM stage. The 3-and 5-year survival rates were: CONCLUSION: BDSR can be justified as an alternative radical operation for patients with middle bile duct in selected patients with no adjacent organ invasion and resection margin is negative.

show abstract

Evidence of Surgical Management of Distal Common Bile Duct Cancer

Liu

2015

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors

View full text Add to dashboard Cite

Prognostic significance of lymph node involvement in middle and distal bile duct cancer

Cited by 59 publications

References 17 publications

Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma

Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma

Carcinoma of the middle bile duct: Is bile duct segmentalresection appropriate?

Evidence of Surgical Management of Distal Common Bile Duct Cancer

Contact Info

Product

Resources

About