Prognostic Significance of Lymph Node Status in p16+ Oropharyngeal Cancer After Surgical Treatment

Park, Young Min; Eo, Tae Seong; Koh, Yoon Woo; Kim, Se‐Heon; Choi, Eun Chang

doi:10.1002/lary.28665

Cited by 3 publications

(1 citation statement)

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“…In contrast to our cohort, many recent datasets are skewed towards less locally advanced disease. 30-32 A recent study from the University of Texas MD Anderson Cancer Center described an ORN rate of 13.7% among all HNSCC patients with a 5% rate of grade 4 ORN. A subset analysis generated for the current manuscript demonstrated that 123/826 oropharyngeal cancer patients (14.9%) developed all grade ORN and 42/825 (5.1%) developed grade 4 ORN.…”

Section: Discussionmentioning

confidence: 99%

Early detection of mandible osteoradionecrosis risk in a high comorbidity Veteran population

Wilde

Kansara

Sapienza

et al. 2022

Preprint

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Objective: Osteoradionecrosis (ORN) of the mandible is a devastating complication of external beam radiation therapy (EBRT) for head and neck squamous cell carcinoma (HNSCC). We sought to ascertain ORN risk in a Veteran HNSCC population treatment with definitive or adjuvant EBRT and followed prospectively. Study design: Retrospective analysis of prospective cohort. Setting: Tertiary care Veterans Health Administration (VHA) medical center. Methods: Patients with HNSCC who initiated treatment at the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) are prospectively tracked for quality of care purposes through the end of the cancer surveillance period (5 years post treatment completion). We retrospectively analyzed this patient cohort and extracted clinical and pathologic data for 164 patients with SCC of the oral cavity, oropharynx, larynx and hypopharynx who received definitive or adjuvant EBRT (2016-2020). Results: Most patients were dentate and 80% underwent dental extractions prior to EBRT of which 16 (16%) had complications. The rate of ORN was 3.7% for oral cavity SCC patients and 8.1% for oropharyngeal SCC patients. Median time to ORN development was 156 days and the earliest case was detected at 127 days post EBRT completion. All ORN patients were dentate and underwent extraction prior to EBRT start. Conclusion: ORN development can occur early following EBRT in a Veteran population with significant comorbid conditions but overall rates are in line with the general population. Prospective tracking of HNSCC patients throughout the post-treatment surveillance period is critical to early detection of this devastating EBRT complication.

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Section: Discussionmentioning

confidence: 99%