Prognostic Significance of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of the Tonsil in Relation to Human Papillomavirus Status and Epidermal Growth Factor Receptor

Fei, Jimin; Hong, Angela; Dobbins, Timothy; Jones, D. Brian; Lee, C. Soon; Loo, Christine; Alghamdi, Mohammad K.; Harnett, Gerald B.; Clark, Jonathan R.; O’Brien, Christopher J.; Rose, Barbara

doi:10.1245/s10434-009-0579-1

Cited by 43 publications

(37 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, assuming EGFR were truly under-expressed in HPV-positive HNSCC, one might expect a reduction in VEGF expression in HPV-positive tumors. However, our study and one other [10] showed no difference in VEGF expression comparing HPV-positive and HPV-negative HNSCC. While this result might be attributable to low statistical power, it is curious that we made this observation in the same sample that showed higher EGFR expression in HPV-negative HNSCC.…”

Section: Discussioncontrasting

confidence: 86%

“…Only two studies reported on VEGF expression in HNSCC according to tumor HPV status and one study showed an association whereas the other did not [10,17]. Few IHC studies have examined the EGFR-VEGF association in HNSCC, with one study reporting a positive association in a heterogeneous HNSCC case series [18], and two studies showing a null association in tonsil [10] and oral cavity cancer [19]. We are unaware of any studies examining the EGFR-VEGF association by tumor HPV status in HNSCC.…”

Section: Introductionmentioning

confidence: 98%

“…Angiogenesis is required for tumor growth, and provides a path for cancer metastasis [8,9]. The strongest biological evidence for differences in angiogenesis comparing HPV-positive and HPV-negative HNSCC comes from immunohistochemistry (IHC) studies of the epidermal growth factor receptor (EGFR), which is expressed at higher levels in HPV-negative compared with HPV-positive HNSCC [10][11][12][13]. EGFR is associated with angiogenesis in HNSCC through activation of the signaltransducer and activator of transcription 3 (STAT3) [14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

Troy

Weissfeld

Youk

et al. 2013

Head and Neck Pathol

View full text Add to dashboard Cite

There is current interest in anti-angiogenesis therapies for head and neck squamous cell carcinomas (HNSCC), although the utility of these therapies in human papillomavirus (HPV) positive and HPV-negative HNSCC is unclear. Therefore, we explored heterogeneity in expression of a distal factor in angiogenesis (EGFR, the epidermal growth factor receptor), a proximal factor in angiogenesis (VEGF, the vascular endothelial growth factor) and a putative factor in angiogenesis (NOTCH1) in a HNSCC case series using immunohistochemistry in N = 67 cases (27 HPV-positive, 40 HPV-negative, by in situ hybridization). Box plots and the Wilcoxon rank sum or Kruskal-Wallis tests were used to compare staining scores (intensity 9 percent of cells staining) by HPV status and lifestyle factors. Associations between EGFR, VEGF, and NOTCH1 were assessed using box plots and Spearman correlation (q) in all cases, and stratified by HPV status.

show abstract

Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

Troy

Weissfeld

Youk

et al. 2013

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…The relationship of HPV status with EGFR protein expression and clinical outcome has been reported in several small series (10,11,18,19,21,26), indicating that best outcomes are observed in patients with HPV-positive tumors with low EGFR expression. An inverse relationship between HPV status and EGFR gene amplification has been reported (27,28); however, to date the relationship between HPV status, EGFR gene copy number, and clinical outcome in HNSCC has not been examined.…”

Section: Introductionmentioning

confidence: 87%

Relationship between Epidermal Growth Factor Receptor Status, p16INK4A, and Outcome in Head and Neck Squamous Cell Carcinoma

Young

Rischin

Fisher

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Human papilloma virus (HPV) infection is a powerful prognostic biomarker in head and neck squamous cell carcinoma (HNSCC). Increased epidermal growth factor receptor (EGFR) gene copy number and protein expression have been reported to be negative predictors of outcome. This study examined the relationship between HPV status, EGFR gene copy number, EGFR protein expression, and clinical outcome in HNSCC patients treated with chemoradiation. Methods: HPV status was determined using p16INK4A immunohistochemistry (IHC), EGFR gene copy number was evaluated with FISH, and EGFR protein expression by IHC in 212 subjects. Results: EGFR FISH was positive in 41 of 204 (20%) patients and was negatively correlated with failure-free survival (FFS; HR = 1.84, P = 0.027) and overall survival (OS; HR = 1.78, P = 0.082). For p16INK4A, 85 of 200 (42.5%) patients were found to be p16 positive, including 75 of 131 (57%) with oropharyngeal cancer. Patients with p16-positive oropharyngeal cancer had significantly improved FFS (HR = 0.28, P < 0.001) and OS (HR = 0.31, P = 0.002). Only 2 of 126 (1.6%) oropharyngeal cancer patients were found to be p16+/EGFR FISH+. EGFR IHC was positive in 81 of 93 (87%) of patients and was associated with poorer FFS (HR = 1.98, P = 0.35) and OS (HR = 2.52, P = 0.22). Conclusions: Increased EGFR gene copy number is largely restricted to p16INK4A-negative oropharyngeal cancer. Although p16INK4A and EGFR FISH are both predictive of outcome in univariate analyses, only p16INK4A remains independently predictive. Impact: Knowledge of HPV and EGFR status can have implications for treatment options and prognosis in HNSCC. Cancer Epidemiol Biomarkers Prev; 20(6); 1230–7. ©2011 AACR.

show abstract

“…The latter results have been conWrmed by Brocic et al, who also rejected VEGF as a clinical parameter for prognosis and outcome [10]. Fei et al [30] analyzed 85 SCC of the tonsil and could not reveal any associations between VEGF and HPV status, gender, patient age, TNM stage or EGFR expression either.…”

Section: Angiogenesismentioning

confidence: 91%

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

Grimminger

Danenberg

2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Oropharyngeal squamous cell carcinomas (OSCC) constitute about 5% of all cancers in the western world and the incidence and mortality rates of this tumor have shown little improvement over the last 30 years. Molecular targeted therapy, a promising strategy for the treatment of OSCC and other cancers, requires the understanding of specific molecular events of carcinogenesis and the different pathological, partly interrelated pathways. Extended knowledge of the prognostic or predictive value of molecular biomarkers in oropharyngeal cancer is necessary to allow a better characterization and classification of the tumor, improve the appraisal of clinical outcome and help to specify individual multimodal therapy with increased efficiency. This work affords an updated summary regarding recent data about tissue biomarkers in patients with OSCC, based on the six essential hallmarks of cancer described by Hanahan and Weinberg (Cell 100(1):57-70, 2000) providing the characterization of a malignant cell.

show abstract

Prognostic Significance of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of the Tonsil in Relation to Human Papillomavirus Status and Epidermal Growth Factor Receptor

Abstract: HPV is a stronger prognostic marker than VEGF or EGFR in tonsillar SCCs. VEGF correlates with MVD in these tumours.

Cited by 43 publications

References 33 publications

Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

Relationship between Epidermal Growth Factor Receptor Status, p16INK4A, and Outcome in Head and Neck Squamous Cell Carcinoma

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

Contact Info

Product

Resources

About