Prognostic value and quality of life in patients with normal rest thallium-201/stress technetium 99m-tetrofosmin dual-isotope myocardial SPECT

Groutars, Reginald G.E.J.; Verzijlbergen, J. Fred; Muller, Alinda J.; Ascoop, C. A. P. L.; Buul, M. M. C. Tiel-Van; Zwinderman, A. H.; Hemel, Norbert M. van; Wall, Ernst E. van der

doi:10.1067/mnc.2000.105634

Cited by 39 publications

(22 citation statements)

References 27 publications

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“…20 Published prognostic studies performed in the USA in patients who underwent pharmacologic stress indicate that such patients are considered at higher risk. [6][7]23 Therefore, the annualized hard event rate of 0.63% for the present study's population is as low as that of studies conducted in the USA. [4][5][6] Risk stratification is essential to the development of evidence-based strategies for improved patient care in medicine.…”

Section: Discussionmentioning

confidence: 88%

“…2,33 Prognostic values of left ventricular functional parameters using QGS have been demonstrated by multiple studies. [1][2][3][4][5][6][7][8][9]23,36 Previous studies found that post-stress LVEF and post-stress ESV assessed during gated SPECT had incremental predictive value in predicting cardiac death. In part, normal myocardial perfusion imaging was associated with a very low likelihood of cardiac death or myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population A Study Based on the J-ACCESS Study

Matsuo

Nakajima

Horie

et al. 2007

Circ J

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population A Study Based on the J-ACCESS Study

Matsuo

Nakajima

Horie

et al. 2007

Circ J

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“…Several prior reports indicated that patients with normal or near-normal stress perfusion have an excellent prognosis [11][12][13][14][15][16]. According to all these studies, the outcome of patients with normal perfusion is excellent, and the same is true for those with very mild perfusion abnormalities.…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

Prognostic implications of post-stress ejection fraction decrease detected by gated SPECT in the absence of stress-induced perfusion abnormalities

Dona

Massi

Settimo

et al. 2010

Eur J Nucl Med Mol Imaging

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Purpose The prognostic meaning of a post-stress ejection fraction (EF) decrease detected by perfusion gated SPECT is still unclear. We therefore followed up patients with post-stress EF decrease in the absence of stress-induced perfusion abnormalities. Methods We prospectively enrolled 57 consecutive patients with post-stress EF drop ≥5 EF units and summed difference score (SDS)≤1. They were followed up for more than 1 year and their outcome was compared with a group of sex-and agematched controls with the same SDS but without EF decrease. Results During follow-up there were 13 events (1 cardiac death, 1 non-fatal myocardial infarction, 1 congestive heart failure and 10 late revascularizations). In the control group we registered six events. There was a significant difference (p<0.0001) between the event-free survival curves of the two groups. ConclusionThe event rate of patients with post-stress EF decrease≥5 EF units is relatively high and is significantly worse than that of a control group of patients with similarly normal SDS but without EF changes. Therefore, a post-stress EF decrease without stress-induced perfusion abnormalities should be cautiously interpreted.

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“…Groutars et al 29 reported good outcome in patients with normal perfusion studies. The annual event rate was 0.8% for any cardiac events.…”

Section: Prognostic Value Of Perfusion Datamentioning

confidence: 99%

“…Our results underscore previously published data on the prognostic value of gated SPECT imaging. [26][27][28][29][30][31][32][33][34] Sharir et al 9 showed that perfusion variables and ESV were powerful markers in the prediction of total coronary events, whereas in the prediction of CD, poststress LVEF and ESV were independent predictors and had incremental value over perfusion data. According to their criteria, patients were at increased cardiac risk when they had an LVEF \ 45% and an ESV [ 70 mL.…”

Section: Prognostic Value Of Functional Datamentioning

confidence: 99%

The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in women

America

Bax

Boersma

et al. 2009

Journal of Nuclear Cardiology

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Background. The aim of this study was to assess the prognostic value of technetium-99m tetrofosmin gated SPECT imaging in women using quantitative gated single photon emission computed tomography (SPECT) imaging.Methods. We followed 453 consecutive female patients. Average follow-up was 1.33 years (max. 2.55). Hard endpoints were cardiac death, acute myocardial infarction, or documented ventricular fibrillation. Event-free survival curves were obtained. Optimal cutoff values for left ventricular (LV) volumes, LV ejection fraction (LVEF), and perfusion data to predict outcome were determined by ROC curve analysis.Results. A total of 236 patients had an abnormal study, of whom 27 patients experienced hard events (16 deaths) and 47 patients soft events. For hard events summed stress score (SSS) and LVEF, and for any cardiac event SSS showed independent incremental prognostic value. The survival curves were maximally separated when using cutoff values for SSS of ‡22 and LVEF < 52% (P < 0.001, HR 4.61 and P < 0.001 HR 5.24 for SSS and LVEF resp.), and SSS ‡ 14 (P < 0.001 HR 3.76) for any cardiac event.Conclusion. In women, perfusion and functional parameters derived from quantitative gated technetium-99m tetrofosmin SPECT imaging can adequately be used for cardiac risk assessment. Using quantitative gated SPECT, female patients with an LVEF < 52% or an SSS ‡ 22 are at increased risk for subsequent hard events. Furthermore, patients with an SSS ‡ 14 are at increased risk for any cardiac events. (J Nucl Cardiol 2009;16:10-9)

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Prognostic value and quality of life in patients with normal rest thallium-201/stress technetium 99m-tetrofosmin dual-isotope myocardial SPECT

Cited by 39 publications

References 27 publications

Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population A Study Based on the J-ACCESS Study

Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population A Study Based on the J-ACCESS Study

Prognostic implications of post-stress ejection fraction decrease detected by gated SPECT in the absence of stress-induced perfusion abnormalities

The additive prognostic value of perfusion and functional data assessed by quantitative gated SPECT in women

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