Prognostic Value and Related Regulatory Networks of MRPL15 in Non-Small-Cell Lung Cancer

Zeng, Yongquan; Shi, Yingying; Xu, Lu; Zeng, Yue; Cui, Xiao; Wang, Yuan; Yang, Ningning; Zhou, Youwen

doi:10.3389/fonc.2021.656172

Cited by 14 publications

(13 citation statements)

References 56 publications

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“…Tumor-infiltrating lymphocyte plays crucial roles in the prognosis of NSCLC ( Fan et al, 2021 ; Zeng et al, 2021 ). First, we used TIMER online analysis tool to examine the relationship between the immune infiltration and the somatic copy number alterations of NCAPG in LUAD.…”

Section: Resultsmentioning

confidence: 99%

FOXM1/lncRNA TYMSOS/miR-214-3p–Mediated High Expression of NCAPG Correlates With Poor Prognosis and Cell Proliferation in Non–Small Cell Lung Carcinoma

Yuan

Jiang

Tang

et al. 2022

Front. Mol. Biosci.

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Lung cancer is the most common cancer with high mortality. Increasing evidence has demonstrated that nonstructural maintenance of chromosomes condensin I complex subunit G (NCAPG) plays a crucial role in the progression of human cancers. However, the biological function and underlying mechanism of NCAPG in non–small cell lung cancer (NSCLC) are still unclear. Here, we utilized diverse public databases to analyze the expression of NCAPG in pan-cancer. We found that NCAPG was highly expressed in various human cancers, especially in NSCLC. NCAPG expression was significantly positively correlated with poor clinical-pathological features, poor prognosis, tumor mutational burden, DNA microsatellite instability, and immune cell infiltration in NSCLC. In addition, our results showed that depletion of NCAPG significantly inhibited NSCLC cell proliferation, migration, and self-renewal abilities, yet these could be reversed by adding microRNA (miRNA)-214-3p. Knockdown of long noncoding RNA (lncRNA) thymidylate synthetase opposite strand (TYMSOS) also inhibits the NSCLC cell proliferation, migration, and self-renewal abilities. In summary, our findings demonstrated that the crucial roles of the FOXM1/lncRNA-TYMSOS/miRNA-214-3p/NCAPG axis in NSCLC may shed light on how NCAPG may act as a therapeutic target for NSCLC.

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Section: Resultsmentioning

confidence: 99%

FOXM1/lncRNA TYMSOS/miR-214-3p–Mediated High Expression of NCAPG Correlates With Poor Prognosis and Cell Proliferation in Non–Small Cell Lung Carcinoma

Yuan

Jiang

Tang

et al. 2022

Front. Mol. Biosci.

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“…MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, promoting tumour progression, and modulating the activity of cell adhesion molecules and cytokines (Joseph et al, 2020;Mondal et al, 2020). MRPL15 is a member of mitochondrial ribosomal proteins whose abnormal expression is related to tumorigenesis in lung cancer, epithelial ovarian cancer and so on (Xu et al, 2021;Zeng et al, 2021). PDK4 is a member of PDK family located in the mitochondrial matrix of cells, inhibiting the entry of pyruvate into the TCA cycle by inhibiting pyruvate dehydrogenase activity.…”

Section: Discussionmentioning

confidence: 99%

Identification of Immune-Related Risk Characteristics and Prognostic Value of Immunophenotyping in TNBC

Shuang

Zhong

et al. 2021

Front. Genet.

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Background: Triple-negative breast cancer (TNBC) is not sensitive to targeted therapy with HER-2 monoclonal antibody and endocrine therapy due to lack of ER, PR, and HER-2 receptors. TNBC is a breast cancer subtype with the worst prognosis and the highest mortality rate compared with other subtypes.Materials and Methods: Breast cancer-related data were retrieved from The Cancer Genome Atlas (TCGA) database, and 116 cases of triple-negative breast cancer were identified from the data. GSE31519 dataset was retrieved from Gene Expression Omnibus (GEO) database, comprising a total of 68 cases with TNBC. Survival analysis was performed based on immune score, infiltration score and mutation score to explore differences in prognosis of different immune types. Analysis of differentially expressed genes was conducted and GSEA analysis based on these genes was conducted to explore the potential mechanism.Results: The findings showed that comprehensive immune typing is highly effective and accurate in assessing prognosis of TNBC patients. Analysis showed that MMP9, CXCL9, CXCL10, CXCL11 and CD7 are key genes that may affect immune typing of TNBC patients and play an important role in prediction of prognosis in TNBC patients.Conclusion: The current study presents an evaluation system based on immunophenotyping, which provides a more accurate prognostic evaluation tool for TNBC patients. Differentially expressed genes can be targeted to improve treatment of TNBC.

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“…Another study has demonstrated that high MRPL15 expression predicts a worse prognosis in non-small cell lung cancer; it revealed potential regulatory networks and demonstrated a negative correlation with immune infiltration (75). MRPL42 is highly expressed in early-stage lung adenocarcinoma (LUAD) tissues and cell lines and is significantly associated with prognosis.…”

Section: Prognosismentioning

confidence: 99%

Potential of Mitochondrial Ribosomal Genes as Cancer Biomarkers Demonstrated by Bioinformatics Results

Bao

Wang

et al. 2022

Front. Oncol.

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Next-generation sequencing and bioinformatics analyses have clearly revealed the roles of mitochondrial ribosomal genes in cancer development. Mitochondrial ribosomes are composed of three RNA components encoded by mitochondrial DNA and 82 specific protein components encoded by nuclear DNA. They synthesize mitochondrial inner membrane oxidative phosphorylation (OXPHOS)-related proteins and participate in various biological activities via the regulation of energy metabolism and apoptosis. Mitochondrial ribosomal genes are strongly associated with clinical features such as prognosis and foci metastasis in patients with cancer. Accordingly, mitochondrial ribosomes have become an important focus of cancer research. We review recent advances in bioinformatics research that have explored the link between mitochondrial ribosomes and cancer, with a focus on the potential of mitochondrial ribosomal genes as biomarkers in cancer.

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Prognostic Value and Related Regulatory Networks of MRPL15 in Non-Small-Cell Lung Cancer

Cited by 14 publications

References 56 publications

FOXM1/lncRNA TYMSOS/miR-214-3p–Mediated High Expression of NCAPG Correlates With Poor Prognosis and Cell Proliferation in Non–Small Cell Lung Carcinoma

FOXM1/lncRNA TYMSOS/miR-214-3p–Mediated High Expression of NCAPG Correlates With Poor Prognosis and Cell Proliferation in Non–Small Cell Lung Carcinoma

Identification of Immune-Related Risk Characteristics and Prognostic Value of Immunophenotyping in TNBC

Potential of Mitochondrial Ribosomal Genes as Cancer Biomarkers Demonstrated by Bioinformatics Results

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