Prognostic value of a rapid sarcopenia measure in acutely ill older adults

Aliberti, Márlon Juliano Romero; Szlejf, Cláudia; Covinsky, Kenneth E.; Lee, Sei J.; Jacob‐Filho, Wilson; Suemoto, Cláudia Kimie

doi:10.1016/j.clnu.2019.08.026

Cited by 27 publications

(20 citation statements)

References 48 publications

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“…Calf circumference measure has been used to estimate muscle mass in the elderly in clinical practice and has a good correlation with gold standard methods even for younger populations. 12 , 13 Studies indicate that the measure is able to predict hospital readmission in adults 14 and survival among the elderly. 15 Our study found correlation between calf circumference and the variables related to HIV, in addition to similar results in the staging of sarcopenia when compared to bioimpedance.…”

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confidence: 99%

Predictors of sarcopenia in young hospitalized patients living with HIV

Almeida¹,

Cortez

Cruz

et al. 2021

The Brazilian Journal of Infectious Diseases

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confidence: 99%

Predictors of sarcopenia in young hospitalized patients living with HIV

Almeida¹,

Cortez

Cruz

et al. 2021

The Brazilian Journal of Infectious Diseases

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“…Our study indicated that low handgrip strength could be an independent predictor for mortality among Chinese inpatients, which is consistent with other previously published studies ( 12 , 41 ). Handgrip strength can be obtained by using simple equipment that is not time-consuming to use and can be applied in any clinical setting, which is very convenient for medical staff ( 42 ). In addition, according to the EWGSOP2 recommendation, muscle strength is a core component of screening for sarcopenia, because it can reflect key features of the disease, and has been reported to accompany an increased risk of adverse outcomes ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Low Handgrip Strength and 90-Day Mortality Among Older Chinese Inpatients: A National Multicenter Prospective Cohort Study

et al. 2021

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Background: The knowledge of the association between low handgrip strength and mortality among older Chinese inpatients is limited. Given China's aging society, a great number of older adults require hospital admission.Objective: To explore the association between low handgrip strength and 90-day mortality, providing evidence for clinicians to predict the risk of mortality and improve clinical outcomes for older inpatients.Materials and Methods: We conducted a national multicenter cohort study with a baseline survey from October 2018 to February 2019 and followed up for 90 days to record mortality outcomes. The assessment of handgrip strength was conducted using a hand dynamometer with the cutoff (handgrip strength < 28 kg for men and < 18 kg for women) to define low handgrip strength. Multivariable logistic regression analysis was applied to explore the association between low handgrip strength and 90-day mortality.Results: A total of 8,910 older Chinese inpatients [mean (SD) age, 72.39 (5.68) years; 3,750 women (42.09%)], with a prevalence of low handgrip strength, at 49.57%, were included. Compared to inpatients with normal handgrip strength, inpatients with low handgrip strength were older, had less education, more were female, had lower activities of daily living (ADL) score, had lower BMI, higher frailty, higher rates of depression, and poorer cognitive function (all p < 0.05). At 90 days, after adjusting for gender, age, education, frailty, depression, ADL score, malnutrition, and diagnosis, low handgrip strength was independently associated with 90-day mortality, compared to normal handgrip strength (OR = 1.64, 95% CI:1.14–2.37; P = 0.008). Additionally, subgroup and interaction analysis showed a significant interaction effect (P = 0.031) between two age groups (65–74 years older vs. ≥ 75 years old), with the OR being 3.19 (95%CI:2.07–4.93) and 1.49 (95%CI:0.87–2.55), respectively.Conclusion: Older Chinese inpatients with low handgrip strength had a 1.64-fold risk of 90-day mortality, compared to those with normal handgrip strength, indicating that clinicians need to screen early for handgrip strength and recommend corresponding interventions, such as resistance training and nutrition, as a priority for older inpatients.Clinical Trial Registration: Chinese Clinical Trial Registry, Identifier: ChiCTR1800017682.

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“… 30 On the other hand, some studies used the standard definition of sarcopenia (<34 cm for men and <33 cm for women). 31 We suspect this is partly the reason that inconsistent results were generated when using different cutoff values.…”

Section: Discussionmentioning

confidence: 99%

“…de Sousa et al 26 also reported similar results among older adults with Alzheimer’s disease. Whereas, recently, Aliberti et al 31 reported that low muscle mass assessed by CC (<33 cm for women or <34 cm for men) was not associated with an increased risk of mortality. A similar study was conducted by Tarnowski et al, 24 who reported that low CC did not significantly increase the risk of mortality among emergency patients.…”

Section: Introductionmentioning

confidence: 93%

Comparing the Performance of Calf Circumference, Albumin, and BMI for Predicting Mortality in Immobile Patients

Zhang

et al. 2021

RMHP

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Background Immobile patients often suffer from malnutrition and low calf circumference (CC), a potential surrogate marker of low muscle mass, which has been widely explored as a link with mortality among patients with inconsistent results. In addition, studies comparing CC, BMI, and albumin to predict mortality among immobile patients are limited. The aim of our study was to compare the performance of these three parameters for predicting mortality among immobile patients. Methods This is a secondary analysis of our previous study consisting of immobile patients, age>18 years. Data were collected between November 2015 and March 2016 by trained nurses through a case report form (CRF) that included clinical data and sociodemographic variables. In addition, anthropometric parameters, including body weight, height and calf circumference, were also measured. The outcome of our study was mortality with follow-up length being 90 days. Multivariate linear and logistic regression analysis were adopted to identify the association between CC and mortality, and a receiver operating characteristic curve analysis was also used to compare the performance of CC, BMI, and albumin. Results Of the 387 patients who were included (51.42% male), with an average age of 61.22 (SD=15.18), the prevalence of mortality was 5.43%. The results showed that, after full adjustment, calf circumference was a protective factor for reducing the risk of mortality (OR=0.79; 95%CI:0.65–0.96). Meanwhile, immobile patients with low calf circumference had an increased risk of mortality, compared to those whose condition was normal (OR=4.24; 95%CI:1.07–16.74). Receiver operating characteristic curve analysis showed that CC combined with albumin (AUC=0.812; 95% CI=0.733–0.890) had the highest AUC value compared to calf circumference (AUC=0.759; 95%CI:0.662–0.856), BMI (AUC=0.653; 95%CI:0.538–0.767) and albumin (AUC=0.735; 95% CI:0.638–0.832), respectively, in predicting mortality in immobile patients. Conclusion The relationship between calf circumference and mortality was significantly negative and low calf circumference was associated with a high risk of 90-day mortality, compared to those with normal calf circumference. The combined calf circumference with albumin had good discrimination in predicting mortality among immobile patients. Therefore, it can routinely be used in a clinical setting by medical staff to predict mortality in immobile patients, as it is easy to obtain.

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Prognostic value of a rapid sarcopenia measure in acutely ill older adults

Cited by 27 publications

References 48 publications

Predictors of sarcopenia in young hospitalized patients living with HIV

Predictors of sarcopenia in young hospitalized patients living with HIV

Association Between Low Handgrip Strength and 90-Day Mortality Among Older Chinese Inpatients: A National Multicenter Prospective Cohort Study

Comparing the Performance of Calf Circumference, Albumin, and BMI for Predicting Mortality in Immobile Patients

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