Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi‐centric lymphoma

Abstract

Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance.

Prognostic Value of Lymphocyte-to-Monocyte Ratio in Canine High-Grade Lymphoma Cases.

“…The median absolute lymphocyte concentration was 1176 cells/µl (ranged between 0-12376 cells/µl; reference range: 1000-4800 cells/µl; Mutz et al, 2015). Eighteen dogs had a lymphocyte count < 1000 cells/µl.…”

Chemotherapy-induced neutropenia is associated with prolonged remission duration and survival time in canine lymphoma

“…Lymphoma accounts for approximately 7-24% of all canine neoplasias and 83% of all canine haematopoietic malignancies (Kaiser, 1981;Moulton and Harvey, 1990). Numerous chemotherapeutic protocols for treating canine lymphoma have been developed over the past 40 years including the multiagent CHOP-based (C-cyclophosphamide; H-hydroxydaunorubicin; O-vincristine; P-prednisolone) protocol, and complete remission rates of 73-92% with median first remission duration (FRD) ranging from 8 to 12 months have been reported (Garrett et al, 2002;Rassnick et al, 2007;Burton et al, 2013;Mutz et al, 2013).…”

Diagnostic value of neutrophil–lymphocyte and albumin–globulin ratios in canine soft tissue sarcoma

“…2014. Recently, a study investigating the NLR in dogs with multi-centric lymphoma found that it was not a significant prognostic variable (Mutz et al . 2013 ), although patient numbers were small in comparison to human studies.…”