Prognostic Value of Combined Tumor Marker and Controlling Nutritional Status (CONUT) Score in Colorectal Cancer Patients

Abstract

Background Nutritional status is strongly associated with prognosis in cancer patients. Controlling Nutritional Status (CONUT) score is a nutritional marker based on serum albumin, cholesterol, and total lymphocyte count. We investigated the prognostic significance of a combination of the tumor marker carcinoembryonic antigen (CEA) and CONUT score (T-CONUT) in colorectal cancer (CRC) patients. Methods A total of 522 patients who underwent surgery for CRC at our hospital were retrospectively enrolled in this study. Results Patients were divided into groups based on the results of receiver operating characteristic (ROC) curve analysis as follows: CONUT high (CONUT score ≥ 3) and CONUT low (CONUT score < 3), and CEA low (< 5 ng/mL) and CEA high (≥ 5 ng/mL). The 5-year overall survival (OS) rates of patients in the CONUT low and CONUT high groups were 76.0% and 53.9%, respectively (P < 0.0001), and in the CEA low and CEA high groups were 80.7% and 47.6%, respectively (P < 0.0001). Regarding T-CONUT, the 5-year OS rates of patients with CEA low /CONUT low , CEA low /CONUT high , CEA high /CONUT low , and CEA high / CONUT high were 84.7%, 69%, 55.3%, and 36.1%, respectively (P < 0.0001). Multivariate analysis identified T-CONUT score as an independent prognostic indicator in CRC patients. Conclusion T-CONUT may be a useful tool for predicting prognosis in CRC patients.

Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

“…A systematic search of the literature resulted in 247 abstracts. After screening the abstracts, 9 full-text manuscripts were assessed for eligibility and included in the present study [9][10][11][14][15][16][17][18][19], as represented in Table 1. All included studies were single-center retrospective series.…”

Prognostic significance of the controlling nutritional status (CONUT) score in epithelial ovarian cancer

“…In recent years, many studies have reported the CONUT score to be a novel predictive index for the prognosis of malignant tumors. It has been shown to be associated with the prognosis of patients with gastric cancer, colorectal cancer, lung cancer, liver cancer, and clear cell renal cell carcinoma 9–13. However, the clinical value of the CONUT score in epithelial ovarian cancer has not been evaluated.…”

The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

“…A variety of laboratory biomarkers have been developed that use the systemic inflammation or nutritonal status of patients as a simple tool. These biomarkers have been demonstrated to predict the prognosis in various cancers, and several studies have demonstrated that these indicators are predictive of the prognosis of patients with CRC 2,7,8 . However, to the best of our knowledge, there is no report on which prognostic indicators are the most useful for CRC patients after curative surgery.…”