Prognostic value of endothelial function for ischemic heart disease in patients with hypertension

Abstract

Aim of the study is to determine the predictive value with respect to the development of coronary heart disease (CHD) of endothelial function activity, inpatients with hypertension (HT) stage II. Methods: We examined 180 patients (men and women) with documented HT stage II. All surveyed people were divided into two groups: the first group consisted of 130 primary HT patients stage II without CHD, the average age of56.5±0.5 years; a second comparison group-50 patients with CHD combined with HT II stage, average age of 58.1±0.8 years. Results: The results of the ROC-analysis showed significantly higher (AUC = 0.80) (95% CI AUC 0,734-0,856) predictive total index of NO2+NO3 in the development of coronary artery disease in hypertensive patients, with an optimal distribution of the threshold of <20.7 mkmol/l sensitivity was 90.0 % and specificity-55.4 %. The high sensitivity (88.0%), to the development of coronary artery disease in hypertensive patients was significantly (AUC = 0.84) ∆V100rg, found at the point of separation of< 88% specificity was 66.2%.