Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

Dai, Jun; Yang, Lili; Wang, Jinyu; Xiao, Ying; Ruan, Qiurong

doi:10.1155/2015/352478

Cited by 50 publications

(56 citation statements)

References 69 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, we found that FOXM1 expression was significantly associated with larger tumor size, higher histological grade, lymph node metastasis, and intrinsic molecular subtypes, which is in line with the literature on female breast cancer and other cancer types [31,43]. Furthermore, FOXM1 expression highly correlated with a high Ki-67 proliferation index (p < 0.001); therefore, we could show that FOXM1 is a proliferation-associated protein in male breast cancer.…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, overexpression of FOXM1 has been reported in a wide range of cancers, namely breast cancer, lung cancer, ovarian cancer, prostate adenocarcinoma, testicular cancer, bladder cancer, and colorectal cancer [17,42]. In general, high FOXM1 expression is recognized as an indicator of poor prognosis [43]. Numerous studies reported that FOXM1 overexpression correlated with tumor histological grade or stage and incidence of metastasis, and inversely correlated with OS [26,28,44].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer

et al. 2017

View full text Add to dashboard Cite

Background: Several studies have outlined biological differences between female and male breast cancer (MBC) and concluded that MBC should be considered as an entirely separate disease. Whether FOXM1 has any indication for prognosis in MBC patients remains unknown. We sought to examine the expression levels of FOXM1 in MBC and to identify the relationship between FOXM1 expression and patient survival. Patients and Methods: FOXM1 expression was evaluated in a total of 130 MBC specimens. Results: FOXM1 was overexpressed in 37% of the MBC samples. FOXM1 overexpression was significantly associated with tumor size (p = 0.045), histological grade (p = 0.048), lymph node metastasis (p = 0.012), Ki-67 proliferation index (p = 0.016), and molecular subtypes (p < 0.001). Multivariate analyses indicated that FOXM1 was an independent prognostic factor for overall survival in MBC patients (p < 0.001, hazard ratio = 0.69 (0.43-0.96)). Conclusions: Overexpression of FOXM1 was associated with well-established markers of poor prognosis; thus FOXM1 may represent a potential novel prognostic marker for MBC.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Forkhead box M1 (FOXM1) is a transcription factor that has been implicated in cell growth and proliferation through control of cell‐cycle transition and apoptosis (Dai, Yang, Wang, Xiao, & Ruan, ) as a promising therapeutic target in various cancers (Z. Wang et al, ). Hence, recently herbal medicines (Bae et al, ; Safe & Kasiappan, ; Tariq et al, ) and natural compounds such as thiostrepton (Zhang et al, ) and casticin (Jiang et al, ) were reported to inhibit the transcriptional activity of FOXM1.…”

Section: Introductionmentioning

confidence: 99%

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Lee

Sim

Jung

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Though lambertianic acid (LA) was known to exert antitumor effect in liver and prostate cancers, its underlying anticancer mechanism is never reported in breast cancers so far. Thus, in this study, apoptotic mechanism of LA was elucidated in MDA-MB-231 breast cancer cells. Here, LA increased cytotoxicity in MCF-7 and MDA-MB-231 cells; enhanced sub-G1 population, G2/M arrest, and cleaved poly(ADP-ribose) polymerase; activated phosphorylation of AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase pathway; and also suppressed phosphorylation of AKT and the expression of forkhead box M1 (FOXM1), X-linked inhibitor of apoptosis protein, B-cell lymphoma 2, and CyclinB1 in MDA-MB-231 cells. Furthermore, AMPK inhibitor compound C reversed the effect of LA on FOXM1, Cyclin B1, and cleaved poly(ADP-ribose) polymerase in MDA-MB-231 cells. Notably, immunoprecipitation revealed that LA disturbed the direct binding of AKT and FOXM1 in MDA-MB-231 cells. Overall, these findings suggest that LA-induced apoptosis is mediated via activation of AMPK and inhibition of AKT/FOXM1 signaling pathway.

show abstract

“…A previous study suggested that FOXM1 could significantly downregulate the expression of P2cipi and P27kipi (7). During the transitional phase between G2 and M, two downstream target genes of FOXM1 were found to promote NF-κB to participate in the progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease (20).…”

Section: Discussionmentioning

confidence: 99%

“…FOXM1 is expressed during the G1 and S phases in the cell cycle, and can regulate the transcription activity of numerous genes, including encoding cell division cycle (Cdc) 25A, Cdc25B, cyclin B, cyclin A, cyclin Dl, p21cip1, p27kipl, Aurora B kinase and Polo-like kinase 1. The loss of FOXM1 expression may lead to formation defects in the mitotic spindle and the delay of cell division, which may result in the failure of mitosis (7). FOXM1 is also associated with cell proliferation and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Sophoridine suppresses cell growth in human medulloblastoma through FoxM1, NF‑κB and AP‑1

Yue

Pan

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. Sophoridine is an alkaloid extracted from Sophora alopecuroides that has extensive pharmacological actions. In the present study, the effect of sophoridine on cell growth of human medulloblastoma and its mechanism were investigated. Human medulloblastoma D283-Med cells were incubated with 0, 0.5, 1 or 2 mg/ml sophoridine for 24, 48 or 72 h. Cell proliferation and cytotoxicity were analyzed using MTT and lactate dehydrogenase assays, respectively. Next, analyses of cell apoptosis and caspase-3/8 activity were performed using flow cytometry or spectrophotometry, respectively. Lastly, the change in FoxM1, TrkB, BDNF, NF-κB and AP-1 expression was investigated using western blot analysis. In the present study, treatment with sophoridine significantly suppressed cell growth and induced apoptosis in human medulloblastoma cells. In addition, sophoridine significantly increased cytotoxicity and caspase-3/8 activity in human medulloblastoma. Finally, it was found that sophoridine suppresses the protein expression of FoxM1, TrkB, BDNF NF-κB and AP-1 in human medulloblastoma cells. The present study suggests that sophoridine suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF-κB and AP-1 signaling pathway.

show abstract

Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

Cited by 50 publications

References 69 publications

Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer

Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer

Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA‐MB231 breast cancer cells

Sophoridine suppresses cell growth in human medulloblastoma through FoxM1, NF‑κB and AP‑1

Contact Info

Product

Resources

About