Prognostic value of Ki67 from clinically and histologically ‘normal’ distant mucosa in patients surgically treated for oral squamous cell carcinoma: a prospective study

The influence of elastin-like recombinant polymer on the self-renewing potential of a 3D tissue equivalent derived from human lamina propria fibroblasts and oral epithelial cells

“…In normal oral mucosa, Ki67 antibody stains less than 20% of the epithelial cells and Ki67 positive cells are limited to the basal layer. However, in premalignant or malignant mucosa abnormal Ki67 positivity is observed also at suprabasal levels [41]. In our model, the Ki67 positive epithelial cells were located strictly at the basal level with the same spatial distribution as in normal oral mucosa, and were uniformly distributed throughout the oral mucosal equivalent.…”

“…Therefore, besides being considered as an overall marker of proliferative activity (identified throughout the cell cycle) [40], it is also frequently used to assess cell epithelial turnover in the oral mucosa [41]. In normal oral mucosa, Ki67 antibody stains less than 20% of the epithelial cells and Ki67 positive cells are limited to the basal layer.…”

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

“…Ki67 is a good predicative marker for cells which have undergone genetic changes and it has been recently shown that there is a relationship between loss of heterogeneity (LOH) and Ki67LI (Montebugnoli et al, 2009). Therefore, based on the obtained results it might be concluded that the number of cells with genetic alterations in OLP is different from that in severe dysplasia and similar to that in mild dysplasia and it can be suggested that severe dysplastic epithelium has a higher susceptibility to malignant transformation compared to OLP and mild dysplasia cases; in addition, malignant transformation potential in OLP and mild dysplasia is higher than that in epithelial hyperplasia with no dysplasia.…”

“…It is revealed that Ki67expression in premalignant and malignant oral lesions increases according to their degree of malignancy (Montebugnoli et al, 2009;Ranganathan and Kavitha, 2011;Dragomir et al, 2012) and increased cellular proliferation might have a potential to be an initial indicator to malignant transformation potential of a lesion (de Sousa et al, 2009a;. Objective of this study is to evaluate and compare cell proliferation rate in OLP , epithelial dysplasia and OSCC through immunohistochemical expression of Ki67.…”

JPEG2000 for automated quantification of immunohistochemically stained cell nuclei: a comparative study with standard JPEG format

“…Ki67 is a nuclear marker used for assessing the proliferative index in a neoplastic cell population (all stages in the cell cycle except G 0 ). The establishment of the growth fraction of neoplasms by quantitatively identifying Ki67-positive cells by immunohistochemistry is useful for the diagnosis (differential or not) of a great number of neoplastic diseases such as lymphoproliferative disorders, breast cancer and other carcinomas [26][27][28][29][30][31]. The staining pattern of proliferating cells has been also demonstrated to be important for the determination of the nuances and pitfalls that may exist in the interpretation of the Ki67 pattern [26].…”