Prognostic value of long non-coding RNA ZEB1-AS1 in Chinese cancer patients

Abstract

Background:Aberrant expression of long non-coding RNA Zinc finger E-box binding homeobox 1 antisense 1 (lncRNA ZEB1-AS1) can be detected in numerous malignancies. Therefore, a meta-analysis had been carried out in this study, aiming to examine the prognostic value of lncRNA ZEB1-AS1 in malignancies.Methods:Electronic databases, such as PubMed, OVID as well as Web of Science, had been systemically retrieved from inception to February 14th, 2019. Besides, the hazard ratios (HRs), together with the corresponding 95% confidence intervals (CIs), had also been analyzed for determining the association of lncRNA ZEB1-AS1 expression with the overall survival (OS) and recurrence-free survival (RFS). In addition, the pooled odds ratios (ORs) would also be computed using the Stata SE12.0 software for evaluating the relationship of lncRNA ZEB1-AS1 expression with pathological factors.Results:A total of 21 original studies involving 1801 cancer patients had been enrolled into the current meta-analysis. As suggested by the pooled HR, high expression of lncRNA ZEB1-AS1 had displayed marked correlation with OS (HR = 2.16, 95% CI: 1.89–2.47) among cancer patients, and no significant heterogeneity was detected. Additionally, high expression of lncRNA ZEB1-AS1 was also markedly associated with RFS among cancer patients (pooled HR = 2.55, 95% CI: 1.61–4.03). Besides, the expression of lncRNA ZEB1-AS1 had displayed marked correlation with poor histological grade (PHG) (OR = 2.86, 95% CI: 2.11–3.87), high tumor stage (HTS) (OR = 3.81, 95% CI: 2.72–5.34) as well as lymph node metastasis (LNM) (OR = 3.33, 95% CI: 2.47–4.49). Additionally, no distinct asymmetry had been detected for RFS, PHG as well as HTS based on Begg funnel plot.Conclusions:Taken together, high expression of lncRNA ZEB1-AS1 can predict the dismal OS, RFS, LNM, PHG, and HTS, indicating that lncRNA ZEB1-AS1 can be potentially used as a new biomarker to predict the dismal prognosis for cancer patients.

LncRNA ZEB1‐AS1 down‐regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma

“…In the current study, ZEB1-AS1 functioned as a regulator of ZEB1 The data from meta-analysis revealed that high ZEB1-AS1 level was closely correlated with overall survival (HR = 2.16, 95% CI: 1.89-2.47), poor histological grade, high tumour staging and lymph node metastasis among patients with cancer, 36 which was similar with previous report. 37 These findings indicate that suppression of ZEB1-AS1 expression may be a potential strategy for therapy of many tumour patients.…”

Significance of Lncrna MIR31HG in Predicting the Prognosis for Chinese Patients with Cancer: A Meta-Analysis

“…Nonetheless, the precise metastasis mechanism in cancer patients is still unclear, even though metastasis will predict dismal prognosis [29,30]. Currently, identifying novel molecular markers is necessary, so as to estimate tumor metastasis, because these markers have crucial parts in cancer treatment and prediction [31]. LncRNAs are one of these molecular markers, which are able to impact the development as well as occurrence of tumor; in addition, they have also been shown to display the potential of easy collection of useful biomarkers to monitor and diagnose tumors [32].…”