Prognostic Value of Long Noncoding RNA SPRY4‐IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta‐Analysis with TCGA Database

Abstract

Background. Emerging evidences have shown that long noncoding RNA SPRY4-IT1 can be aberrantly expressed in human cancers, and it could be an unfavorable prognostic factor in cancer patients. However, the prognostic mechanism of SPRY4-IT1 is still unclear. This study is aimed at evaluating its potential predictive value for cancer prognosis. Methods. We thoroughly searched PubMed, Embase, Web of Science, and MEDLINE databases so as to explore the relationship between SPRY4-IT1 expression and cancer prognosis value. Then, TCGA datasets were used to validate the results of our meta-analysis. Results. In all, seventeen studies involving 1650 patients were included in this meta-analysis. Pooled results showed that high expression of SPRY4-IT1 was significantly correlated with poor OS ( HR = 1.96 , 95% confidence interval CI = 1.47 ‐ 2.62 , P < 0.001 ) in cancer patients. Furthermore, exploration of TCGA dataset further validated that SPRY4-IT1 was aberrantly expressed in various cancers, which partially confirmed our results in this meta-analysis. Conclusions. The present systematic review and meta-analysis implicated that the aberrant expressions of lncRNA SPRY4-IT1 were strongly associated with clinical survival outcomes in various cancers and therefore might serve as a promising biomarker for predicting prognosis of human cancers.

A Systematic Review and Meta‐Analysis of the Associations between Immigration Status and Stroke Incidence and Mortality

“…Literature Search. This study used the method of Hai-mei Wang et al [8], and the description of the methods partly reproduces their wording. The present study was rigorously designed and reviewed according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement checklist [9][10][11].…”

“…Literature published from 2000 to 2022 was included to capture the most recent information. Additionally, the citation lists of these retrieved articles were manually screened to ensure the sensitivity of the search strategy [8].…”

“…At the same time, WHZ confirmed the accuracy of the extracted relevant information. When more than one HR was reported, the most adjusted HR would be extracted [8]. The extracted HRs and 95% confidence intervals (CIs) were standardized into the form of immigrant groups vs. the host populations.…”

“…The extracted HRs and 95% confidence intervals (CIs) were standardized into the form of immigrant groups vs. the host populations. Due to the low overall risk of stroke among migrant populations in the included literature, HRs in the cohort studies were mathematically similar to the relative risks (RRs) and odds ratios (ORs) in the cohort studies [8]. Therefore, if the results of RR ratios were provided in the studies, multivariate analysis results would be extracted prior to that of univariate analysis.…”

“…If a certain study only provided the RR ratios for immigrants from different countries of origin separately, we would calculate the pooled HRs and 95% CIs through indirect extraction. If data of interest were not accessible, we would obtain the missing data from the corresponding authors of included articles [8]. Since all studies included in our meta-analysis were cohort studies, the Newcastle-Ottawa Scale (NOS) was used to assess the quality of each by two independent authors (JZC and HMW).…”