Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Sun, Zhenqiang; Ma, Shuai; Zhou, Quanbo; Yang, Shenghong; Chang, Yuan; Zeng, Xiangyue; Ren, Weiguo; Han, Fanghai; Xie, Xiang; Zeng, Fanye; Sun, Xiantao; Wang, Guixian; Li, Zhen; Zhang, Zhiyong; Song, Junmin; Liu, Jinbo; Yuan, Weitang

doi:10.3748/wjg.v23.i48.8582

Cited by 36 publications

(37 citation statements)

References 34 publications

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“…The present study determined the prognostic value of NK cells in CRC patients; the value was moderate for the prediction of the 1st, 2nd, and 3rd year of survival. Previous studies have reported that blood CEA, CA199, and B lymphocyte counts are associated with survival in CRC patients [27][28][29]. We confirmed these associations in the present study.…”

Section: Discussionsupporting

confidence: 92%

Prognostic value of peripheral blood natural killer cells in colorectal cancer

Tang

Xie

et al. 2020

BMC Gastroenterol

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Background: The association between natural killer (NK) cells and survival in colorectal cancer (CRC) patients remains controversial. This study aimed to clarify the prognostic value of peripheral blood NK cells in CRC patients.Methods: A total of 447 CRC patients who underwent radical surgery and chemotherapy were retrospectively analyzed. Cox regression analyses were used to identify independent prognostic indicators. Correlation between NK cell percentage and other clinicopathological features (gender, age, histological grade, tumor stage, immune cells, and inflammatory indicators) was analyzed. The prognostic values of the combinations of NK cell percentage and other clinicopathological features were also determined. Results: Multivariate Cox regression analysis revealed that NK cell percentage in the peripheral blood was an independent prognostic indicator in CRC patients. A higher percentage of NK cells indicated a longer survival time than a lower percentage. NK cell percentage was positively correlated to the T and B lymphocyte counts and negatively correlated to the patients' age and albumin levels. With an area of 0.741 under a receiver operating characteristic curve, NK cells have a moderate predictive value for 3rd-year survival in CRC. This area increased to 0.851 by combining NK cell percentage with the B lymphocyte count. Elderly patients and those at an advanced clinical stage presented a lower percentage of NK cells than younger patients and those at an early clinical stage.Conclusions: This study demonstrated that NK cells in the blood were an independent predictor of survival in CRC patients, and the combined count of NK cells and B lymphocytes could increase the prognostic value.

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Section: Discussionsupporting

confidence: 92%

Prognostic value of peripheral blood natural killer cells in colorectal cancer

Tang

Xie

et al. 2020

BMC Gastroenterol

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“…A previous study had demonstrated that CEA and CA19-9 were independent predictive factors of liver metastasis of colorectal cancer through LNM [28]. Also, several studies had illustrated there was association between elevation of the CA19-9 and CA72-4 levels and presence of LNM in EGC patients, and elevation of the CEA level was proved to be an independent predictor for the poor prognosis of EGC [29,30]. However, a study indicated that CEA was unrelated to LNM in EGC [31].…”

Section: Discussionmentioning

confidence: 96%

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

et al. 2020

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Background: The status of lymph nodes in early gastric cancer is critical to make further clinical treatment decision, but the prediction of lymph node metastasis remains difficult before operation. This study aimed to develop a nomogram that contained preoperative factors to predict lymph node metastasis in early gastric cancer patients. Methods: This study analyzed the clinicopathologic features of 823 early gastric cancer patients who underwent gastrectomy retrospectively, among which 596 patients were recruited in the training cohort and 227 patients in the independent validation cohort. Significant risk factors in univariate analysis were further identified to be independent variables in multivariable logistic regression analysis, which were then incorporated in and presented with a nomogram. And internal and external validation curves were plotted to evaluate the discrimination of the nomogram. Results: Totally, six independent predictors, including the tumor size, macroscopic features, histology differentiation, P53, carbohydrate antigen 19-9, and computed tomography-reported lymph node status, were enrolled in the nomogram. Both the internal validation in the training cohort and the external validation in the validation cohort showed the nomogram had good discriminations, with a C-index of 0.82 (95%CI, 0.78 to 0.86) and 0.77 (95%CI, 0.60 to 0.94) respectively. Conclusions: Our study developed a new nomogram which contained the most common and significant preoperative risk factors for lymph node metastasis in patients with early gastric cancer. The nomogram can identify early gastric cancer patients with the high probability of lymph node metastasis and help clinicians make more appropriate decisions in clinical practice.

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“…In addition, serum CA724 levels and pN stage were independent prognostic factors of CRC, indicating that both were correlated to tumorigenesis. A study by Sun et al (2017) showed that an elevation in serum CA724 levels suggested that tumor cells had metastasized through the lymphatic or other pathways and had colonized at an another location. The lymph system was a common metastatic pathway of gastrointestinal cancer (Li et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Kuang

Gong

Xie

et al. 2020

PeerJ

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Background and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. The Chi-square test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan–Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results In the Chi-square test, only pathological node stage (pN stage) (X2 = 14.514, P = 0.001) and differentiation (X2 = 10.712, P = 0.001) were associated with serum CA724 levels. In the Kaplan–Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels.

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Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Cited by 36 publications

References 34 publications

Prognostic value of peripheral blood natural killer cells in colorectal cancer

Prognostic value of peripheral blood natural killer cells in colorectal cancer

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

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