Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention

Abstract

Objective:We sought to determine the role of mean platelet volume (MPV) for predicting long-term outcomes of elective percutaneous coronary intervention (PCI).Methods:On the basis of retrospective cohort study, we collected characteristics of 680 patients undergoing elective PCI from October 2005 to August 2010. The patients who had preoperative MPV were assessed for developing major adverse cardiac events (MACE) during 1-year follow-up. They were categorized into two groups including MPV <9.6 fL (n=89) and MPV ≥9.6 fL (n=92). Data were analyzed using t-test, chi-square test, Pearson correlation, receiver operating characteristic (ROC) curve and logistic regression.Results:One-hundred eighty one patients (26.6%) met inclusion criteria. The MACE was observed in 29 patients (16%); and its rate in low- and high-MPV groups was 11.2% and 20.7%, respectively (p=0.084). MPV was significantly higher in the patients with left ventricular ejection fraction (LVEF) <40% compared with that of ≥40% (p<0.001). There were a significant and negative correlation between MPV and platelet count (r=-0.305, p<0.001), and significant and positive correlations between MPV and platelet distribution width (PDW) and platelet large cell ratio (P-LCR) (r=0.615, p<0.001 and r=0.913, p<0.001; respectively). The best MPV cut-off point was 9.25 fL; the sensitivity and specificity were 79% and 38%, respectively. Elevated MPV was the best predictor of MACE at 1-year follow-up (OR=11.359, 95% CI 2.481-51.994, p=0.002).Conclusion:The results indicate that preoperative MPV is an independent predictor of the MACE at 1-year follow-up in the patients undergoing elective PCI. Moreover, it may be useful for risk stratification in such cases.

Platelet distribution width as the prognostic marker in coronary bifurcation treatment

“…found that the best MPV cutoff point was 9·25 fL with sensitivity and specificity of 79% and 38%, respectively. This elevated MPV value was the best predictor of MACE at 1‐year follow‐up (OR = 11·3, 95% CI 2·4‐51·9, P = 0·002) .…”

Slow Coronary Flow Phenomenon and Increased Platelet Volume Indices

“… 8) 9) Mean platelet volume (MPV), an index of platelet activation, has been shown to be associated with adverse cardiovascular outcomes. 10) MPV was found to be elevated in SCF cases compared to normal ones. 11) Platelet distribution width (PDW) is found to be increased during platelet activation.…”

White blood cell count to mean platelet volume ratio as a novel non-invasive marker predicting long-term outcomes in patients with non-ST elevation acute coronary syndrome

“…The mean platelet volume, a platelet activation marker, is a widely available and easily measured hematologic test in a complete blood cell count test [7], and the elevated one has been demonstrated to be associated with diabetes mellitus, hypertension, hypercholesterolemia, and obesity [7]. In addition, it has been found to be a diagnostic and prognostic marker in patients with ACS or those undergoing percutaneous coronary intervention [15][16][17]. However, in a prospective study, no relationship was found between increased baseline mean platelet volume and the clinical outcomes of patients undergoing elective angioplasty, but increases in postoperative serial measurements were associated with higher mortality rate instead [18].…”